A5075989064- Fetal and Pediatric Neurological Disorders
- Down syndrome and intellectual disability research
- Neonatal and fetal brain pathology
- Prenatal Screening and Diagnostics
- Advanced Neuroimaging Techniques and Applications
- Medical Image Segmentation Techniques
- Neonatal Respiratory Health Research
- Functional Brain Connectivity Studies
- Congenital Diaphragmatic Hernia Studies
- Domain Adaptation and Few-Shot Learning
- Congenital heart defects research
- Brain Tumor Detection and Classification
- Pregnancy and preeclampsia studies
- Intestinal Malrotation and Obstruction Disorders
- Birth, Development, and Health
- Cleft Lip and Palate Research
- Preterm Birth and Chorioamnionitis
- Gestational Diabetes Research and Management
- Immune Response and Inflammation
King's College London
2014-2023
St Thomas' Hospital
2015-2023
Kings Health Partners
2016-2021
KU Leuven
2021
Hammersmith Hospital
2012
Imperial College London
2012
The fetal brain shows accelerated growth in the latter half of gestation, and these changes can be captured by 2D 3D biometry measurements. aim this study was to quantify normal fetuses using Magnetic Resonance Imaging (MRI) produce reference data a freely available centile calculator ( https://www.developingbrain.co.uk/fetalcentiles/ ). A total 127 MRI examinations (1.5 T) with appearance (21–38 gestational weeks) were included study. biometric parameters measured from slice-to-volume...
Down Syndrome (DS) is the most frequent genetic cause of intellectual disability with a wide spectrum neurodevelopmental outcomes. At present, relationship between structural brain morphology and cognitive phenotypes in DS, not well understood. This study aimed to quantify development fetal neonatal DS participants, without congenital cardiac defect compared control population using dedicated, optimised motion-corrected vivo magnetic resonance imaging (MRI). We detected deviations altered...
In this study, we construct a spatio-temporal surface atlas of the developing cerebral cortex, which is an important tool for analysing and understanding normal abnormal cortical development. utero Magnetic Resonance Imaging (MRI) 80 healthy fetuses was performed, with gestational age range 21.7 to 38.9 weeks. Topologically correct models were extracted from reconstructed 3D MRI volumes. Accurate correspondences obtained by applying joint spectral analysis cortices sets subjects close...
Down syndrome (DS) is the most common genetic cause of intellectual disability with a wide range neurodevelopmental outcomes. To date, there have been very few in vivo neuroimaging studies neonatal brain DS. In this study we used cross-sectional sample 493 preterm- to term-born control neonates from developing Human Connectome Project perform normative modeling regional tissue volumes 32 46 weeks postmenstrual age, accounting for sex and age variables. Deviation mean was quantified 25 DS...
Infants born preterm are at increased risk of neurological complications resulting in significant morbidity and mortality. The exact mechanism the impact antenatal factors has not been fully elucidated, although infection/inflammation implicated both aetiology birth subsequent sequelae. It is therefore hypothesized that processes driving affecting brain development utero. This study aims to compare MRI derived regional volumes fetuses deliver < 32 weeks with subsequently term. Women high...
In this article, we focus on the causes of individual differences in Down syndrome (DS), exemplifying multi-level, multi-method, lifespan developmental approach advocated by Karmiloff-Smith (1998, 2009, 2012, 2016). We evaluate possibility linking variations infant and child development with (elevated) risk for Alzheimer's disease (AD) adults DS. review theoretical basis argument, considering genetics, epigenetics, brain, behaviour environment. studies 1 2, variation language development....
Abstract Down syndrome (DS) occurs with triplication of human chromosome 21 and is associated deviations in cortical development evidenced by simplified gyral appearance reduced surface area. Radial glia are neuronal glial progenitors that also create a scaffolding structure essential for migrating neurons to reach targets therefore play critical role development. The aim this study was characterise radial expression pattern morphology the frontal lobe developing fetal brain DS age-matched...
Congenital diaphragmatic hernia is associated with high mortality and morbidity, including evidence suggesting neurodevelopmental comorbidities after birth. The aim of this study was to document longitudinal changes in brain biometry the cortical folding pattern fetuses congenital compared healthy fetuses.
The neurodevelopmental phenotype in Down Syndrome (DS), or Trisomy 21, is variable including a wide spectrum of cognitive impairment and high risk early-onset Alzheimer's disease (AD). A key metabolite interest within the brain DS Myo-inositol (mIns). NA+/mIns co-transporter located on human chromosome 21 overexpressed DS. In adults with DS, elevated mIns was previously associated proposed as marker for progression to AD. However, it unknown if increased earlier development. aim this study...
Abstract Down Syndrome (DS) is the most frequent genetic cause of intellectual disability with a wide spectrum neurodevelopmental outcomes. At present, relationship between structural brain morphology and cognitive phenotypes in DS, not well understood. This study aimed to quantify development fetal neonatal DS using dedicated, optimised motion-corrected in-vivo magnetic resonance imaging (MRI). We detected deviations altered regional growth fetus from 21 weeks’ gestation, when compared...
Fetal cases with known genetic syndromes and GA matched controls were retrospectively selected. All had same day US MRI (iFIND-2 project: REC:14/LO/1806). 3D was obtained by combining multiple stacks of T2 weighted slices using slice to volume reconstruction. A semi-automated segmentation performed then visualised as a model. fetal sonographer/radiographer compared the surface rendered quality scored from suboptimal excellent (1 5) or not achievable (0). 22q11.2 microdeletion syndrome T21 (4...
ABSTRACT Down syndrome (DS) is the most common genetic cause of intellectual disability with a wide spectrum neurodevelopmental outcomes. Magnetic resonance imaging (MRI) has been used to investigate differences in whole and/or regional brain volumes DS from infancy adulthood. However, date, there have relatively few vivo neonatal studies DS, despite presence clearly identifiable characteristics at birth. Improved understanding early development needed assess phenotypic severity and identify...
Objective To document longitudinal changes in brain development fetuses with congenital diaphragmatic hernia (CDH). Design Retrospective cohort study Setting Single tertiary fetal surgery center Population Fetuses isolated CDH and at least two MRI-examinations (n=42 fetuses). Fifty-six who underwent MRI for a condition not interfering or from healthy volunteers served as controls. Methods Biometry included biparietal fronto-occipital diameter, ventricular atrial width, transcerebellar head...
There are relatively few early neuroimaging studies of Down syndrome (DS), despite being the most common genetic cause intellectual disability, with characteristics present from birth. The aim this study was to conduct a group-level analysis volumetric differences across multiple brain regions in neonates DS (n = 20) using individual z-scores extracted robust normative modelling typically developing neonatal controls (TDC; n 493). In addition well-documented cerebellar hypoplasia, here we...
Toll-like receptors (TLR), found on glial and neuronal cells, are major components of the innate immune system. They act as sensors that recognise pathogen-associated or damage-associate molecular patterns. There is limited information these in immature brain. Generally TLR-2 triggered via gram-positive bacterial infections, however, recent research animal models have TLR2 plays an important role brain injury following hypoxic-ischaemia (HI)1 TLR3 activation further enhances HI-induced...
Abstract The neurodevelopmental phenotype in Down Syndrome (DS), or Trisomy 21, is variable including a wide spectrum of cognitive impairment and high risk early-onset Alzheimer’s disease (AD). A key metabolite interest within the brain DS Myo-inositol (Myo-ins). NA+/Myo-ins co-transporter, located on human chromosome 21 overexpressed DS. In adults with DS, elevated Myo-ins has previously been associated proposed as marker for progression to AD. However, it unknown if increased earlier...
The cerebral cortex performs higher-order brain functions and is thus implicated in a range of cognitive disorders. Current analysis cortical variation typically performed by fitting surface mesh models to inner outer boundaries investigating metrics such as area curvature or thickness. These, however, take long time run, are sensitive motion image resolution, which can prohibit their use clinical settings. In this paper, we instead propose machine learning solution, training novel...