A5062750812- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Respiratory viral infections research
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- HIV, TB, and STIs Epidemiology
- Tracheal and airway disorders
- Peripheral Neuropathies and Disorders
- Syphilis Diagnosis and Treatment
- Bacteriophages and microbial interactions
- Brucella: diagnosis, epidemiology, treatment
- Virology and Viral Diseases
- Anorectal Disease Treatments and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Voice and Speech Disorders
- Reproductive tract infections research
- Cardiovascular Syncope and Autonomic Disorders
- Urinary Bladder and Prostate Research
- Pregnancy and Medication Impact
- Pelvic floor disorders treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Gabrichevsky Institute of Epidemiology and Microbiology
2014-2023
Czech Academy of Sciences, Institute of Microbiology
2020
Objective. To analyze the features of whooping cough in patients under 1 year age and state transplacental protection children month modern conditions. Patients methods. The clinical analysis is based on observations 424 hospitalized Clinical Hospital Infectious Diseases No period 2017–2019. verify cough, PCR ELISA methods were used with Ridascreen/Bordetella pertussis test system (R-biofarm AMG, Germany), which allows detecting antibodies various classes (IgM, IgG, IgA). Serological...
Objective. Studying the clinical efficacy of experimental justification hydrocortisone use in severe pertussis. Patients and methods. The study was carried out State Budgetary Institution Children's Infectious Disease Clinical Hospital No.1 Moscow Health Department. A total 206 children with pertussis, aged from 0 to 3–4 months, pertussis were under observation. indication for prescribing drug presence apnea accompanied by spasmodic cough. Group I (n = 166) consisted who received along...
Objective: to assess anti-pertussis immunity in schoolchildren aged 7–17 who complained of a prolonged cough during the 11-year follow-up period. Materials and methods. The study included 1046 patients 7 17 years applied Consultative Diagnostic Center G.N. Gabrichevsky Research Institute Epidemiology Microbiology with complaints period from 2010 2020. Blood serums were examined ELISA determination IgM, IgG, IgA antibodies using RIDASCREEN test system (Germany). Results. An active infection...
In the article there is presented comparative analysis of character specific humoral response to pertussis in dependence on age, terms disease and vaccination history 279 patients, among which 114 patients were under 1 165 - over year age. study level production antibodies different isotypes unvaccinated age medical examination it has been revealed that was typical low all classes any time disease, especially IgM. It shown babies aged from 0 3 4 6 months old these immunoglobulins at early...
В статье представлен анализ клинико-диагностических особенностей коклюша у детей старшего возраста. Удельный вес данной возрастной группы среди госпитализированных составлял 11,3±2,7–13,3±2,7% с преобладанием привитых против этой инфекции больных. У 93,6±3,6% пациентов заболевание протекало в среднетяжелой форме типичным симптомокомплексом. Для верификации клинического диагноза был использован метод полимеразной цепной реакции (ПЦР) и серологический – иммуноферментный (ИФА). Эффективность...
Meningococcal, pneumococcal, streptococcal A and Haemophilus influenzae infections are manifested in different clinical forms, ranging from bacterial carriage to generalized life-threatening conditions. However, a connection between disease development has not been fully explored. PCR assay was performed with adenoid biopsy samples collected 112 children after planned adenotomy detect Neisseria meningitidis, Streptococcus pneumoniae, pyogenes, H. carriage. DNA specific at least one of the...
Objective. To study the features of clinic and serological diagnosis pertussis in adults. Patients methods. The included patients admitted to Infectious diseases clinical hospital No 1 2018 with prolonged cough syndrome. Clinical methods were used for monitoring adult pertussis. Information about course disease is recorded "case histories" observation cards. verify whooping cough, blood was examined detect anti-pertussis antibodies class IgM, IgG, IgA using an enzyme-linked immunosorbent...
Актуальность. Урогенитальный хламидиоз – наиболее распространенная бактериальная инфекция, передаваемая половым путем, сопровождающаяся высокой частотой осложнений (хронический простатит, сальпингоофорит и др.) неблагоприятных последствий (нарушение половой репродуктивной функций). В последние годы отмечается нарастание персистирующей хламидийной инфекции, которая не поддается лечению антибиотиками диагностируется на основании обнаружения методом иммуноферментного анализа антител...
Because of low effectiveness laboratory methods for diagnosing pertussis it is important to look new ways verification this infection. The article presents the analysis diagnostic value ELISA method, which involves identification antibodies different isotypes (IgM, IgG, IgA) toxoid (PT) and filamentous haemagglutinin (FHA). study included 279 children: 114 were under 1 year age, 165 — older than year. was confirmed in 74.3 ± 2.6% patients by using method. A significant proportion...
The article presents the analysis of clinical and immunological features combined course pertussis respiratory chlamydia in children. study prodromal period spasmodic cough symptoms showed that concomitant chlamydial infection did not significantly affect severity pertussis: 63.2% patients had mild degree 36.8% — moderate disease. However, this case, disease was delayed. Bronchitis some cases obstructive bronchitis observed mainly children under 1 year. lymphocytes subpopulation found...
Aim. To study the clinical course, diagnosis of pertussis in pregnant women. Materials and methods. Under observation were 25 women with whooping cough. The age structure was dominated by patients from 6 to 35 years old, amounting 64%. At time hospitalization 2 (8%) gestation period corresponded first trimester, 7 (28%) II, 9 (36%) III. In patients, cough made during childbirth. following methods used verify pertussis: bacteriological, PCR serological (ELISA). Results discussion. Clinical...
Background: The interepidemic meningococcal infection (MI) period in Moscow has been going since the 1989. Outbreaks of general forms MI (GFMI) were registered 1996, 2003, 2008 with their morbidity rates per 100,000 persons (MR) 4.23, 3.63 and 2.59. In 2012 MR was at 1.56. Methods & Materials: Meningococcus strains isolated from GFMI patients Infectious Diseasaes Clinic serogrouped, specifics immunological structure population defined. Results: predominance serogroup A (MSA) shown. highest...
The below case of the development reactive arthritis against background coinfection Chlamydia trachomatis and pneumoniae is interesting by features clinical picture, duration course, complexity diagnosis, laboratory observation, a comprehensive approach to therapy.
 Reactive belongs group seronegative spondyloarthritis, has variety symptoms with damage various organs systems. All patients have pathology peripheral joints and/or axial skeleton. disease immuno-inflammatory in nature, may...
Study the possibility of inclusion complex immunoglobulin preparation (CIP) pos- sessing specific activity against pertussis exotoxins into therapy infection in young children.-2 groups children with.pertussis younger than 3 years were examined. The main group (50 individuals) received CIPper os - 1 dose 2 times per day for 5 days, comparison (34 children) only basic therapy. Evaluation clinical effectiveness CIP was carried out, content anti-pertussis class G antibodies and total IgE...
Comparative analysis of efficiency identification the anti-pertussis antibodies three classes (IgM, IgG, IgA) by means four commercial test systems used for serological diagnosis whooping cough in Russian Federation RIDASCREEN (R-Biohharm AG, Германия), NOVATEC (Immunodiagnostica GmbH, Germany), DRG Diagnostics (Germany), Savyon (Israel) is carried out. The research included 42 serums blood children and adults with hospitalized Infectious diseases clinical hospital No. 1 Moscow Department...
The aim of the work was to assess effectiveness serodiagnosis pertussis in people over 50 who complained prolonged cough. study included 30 patients age applied consultative diagnostic center complaining a cough period from 2015 - 2020. Blood serum samples were investigated enzyme immunoassay with definition antitussive antibodies three classes IgM, IgG, IgA commercial test system RIDASCREEN (R-Biopharm AG, Germany). It found that individuals 50, IgM above threshold level not detected....
Цель исследования. Клинико-иммунологическая оценка эффективности применения азоксимера бромида у больных коклюшем. Характеристика детей и методы Под наблюдением находились 50 от 6 мес до 14 лет. В комплекс терапии 25 (основной группы) был включен бромид, (группа сравнения) получали базисную терапию. Результаты. Выраженность симптомокомплекса обеих наблюдаемых групп соответствовала течению среднетяжелой формы коклюша. Клинический диагноз подтвержден методом полимеразной цепной реакции...
Purpose: to investigate the level anti-pertussis IgM, IgG, IgA in pregnant women I — II III trimesters. Materials and methods. A total of 288 aged. 17 43 years (in trimesters) were examined. serums samples tested for against pertussis by ELISA RIDASCREEN (Germany). Results. Anti-pertussis IgG concentration below low limit detection occurred 75,7% women. The majority seropositive among was age group 26 35 (82,9%). proportion seronegative increased. with increasing pregnancy periods, as well...