A5021634481- Health disparities and outcomes
- Parkinson's Disease Mechanisms and Treatments
- Health and Conflict Studies
- Migration, Health and Trauma
- Employment and Welfare Studies
- Nuclear Receptors and Signaling
- Chronic Disease Management Strategies
- Neurological disorders and treatments
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Global Cancer Incidence and Screening
- Autism Spectrum Disorder Research
- Global Health Care Issues
- Early Childhood Education and Development
- School Health and Nursing Education
- EFL/ESL Teaching and Learning
- Global Health Workforce Issues
- Spatial and Panel Data Analysis
- Occupational Health and Performance
- Geriatric Care and Nursing Homes
- Smoking Behavior and Cessation
- Musculoskeletal Disorders and Rehabilitation
- COVID-19 Digital Contact Tracing
- Mental Health Treatment and Access
- Hospital Admissions and Outcomes
University of Manchester
2018-2022
Manchester Academic Health Science Centre
2018-2021
Parkinson's UK
2013
University of Oxford
2005-2013
Pediatrics and Genetics
2013
Centre for Human Genetics
2005-2008
Royal Perth Hospital
1995
Eli Lilly (United States)
1977
Significance Elevated expression of the presynaptic protein α-synuclein underlies familial and sporadic Parkinson disease (PD). However, our understanding how increases in levels drive sequence events leading to PD is incomplete. Here, we apply a multidisciplinary longitudinal analysis new transgenic mouse model. We show that early-stage decreases dopamine release vesicle reclustering precede late-stage changes neuronal firing properties, measured by vivo recordings from vulnerable neurons....
Abstract Alpha‐synuclein is intimately involved in the pathogenesis of Parkinson's disease, and has been implicated regulation synthesis, release reuptake dopamine (DA). However, mice lacking members synuclein family have reported to display no overt behavioural phenotype. This may be a result compensatory upregulation other synucleins during development. Here we report on behaviour DA synapse function alpha‐synuclein null, gamma‐synuclein alpha‐gamma‐synuclein double‐null knockout mice....
Parkinson's disease (PD) is a neurodegenerative disorder classically characterized by the death of dopamine (DA) neurons in substantia nigra pars compacta and intracellular Lewy bodies composed largely α-synuclein. Approximately 5-10% PD patients have familial form Parkinsonism, including mutations To better understand cell-type specific role α-synuclein on DA neurotransmission, effects disease-associated A30P mutation, we generated studied novel transgenic model PD. We expressed mutant...
The microtubule-associated protein tau (MAPT) and α-synuclein (SNCA) genes play central roles in neurodegenerative disorders. Mutations each gene cause familial disease, whereas common genetic variation at both loci contributes to susceptibility sporadic disease. Here, we demonstrate exquisite regulation of the human MAPT SNCA transgene functional complementation neuronal cell cultures organotypic brain slices using herpes simplex virus type 1 (HSV-1) amplicon-based infectious bacterial...
Tobramycin sulphate, a bactericidal aminoglycoside antibiotic, has been evaluated worldwide in 3,506 patients. Drug-related adverse effects were reported by the investigators 3 · 9% of cases, and included reactions nervous system (ototoxicity) 0·6% kidney 1·5%. Effects doubtful relationship to tobramycin occurred 6·6% cases. The usually reversible, although infrequently altered renal or eighth-nerve function appeared persist some There no deaths instances shutdown as result therapy....
Abstract Background Contact tracing was central to England’s approach controlling coronavirus disease 2019 (COVID-19). COVID-19 contact system included a step where cases were invited provide information through an online ‘self-service’ portal. It is important understand whether this had any effect on the numbers of contacts reported. Methods This study analyses data for one local authority in England 2021. Univariable negative binomial and logistic regression models used test associations...
Abstract Background The English Indices of Multiple Deprivation (IMD) is widely used as a measure deprivation. However, similarly ranked areas can differ substantially in the underlying domains These contain richer set data that might be useful for classifying local authorities. Clustering methods offer techniques to identify groups with similar patterns Methods Hierarchical agglomerative (i.e. bottom-up) clustering were applied domain scores 152 upper tier Advances statistical testing allow...
ABSTRACT BACKGROUND More than four out of five people in England live an urban area so the environment is important determinant health and contributor to inequalities. This especially true for children, whom impacts their local may have lifelong effects. To improve effects London Devolution Partnership piloted multi-agency partnerships focusing on 400m ‘superzones’ around schools deprived communities. The intention partners work together make within superzone healthier. METHODS A realist...
Background Early child development predicts a range of later outcomes including educational achievement, employment, involvement in crime, health, and social care need. Inequalities early childhood also cause inequalities health on life. Because this, is an important time for intervention. School readiness England used to refer assessment child's cognitive, emotional, physical development, major focus effort local national policymakers. However, evidence what factors affect school needed...
Background Local authorities and other service providers need data on their local ex-military communities to be able plan services. However, published research may not applicable the population. Qualitative offers a relatively low-cost way get insights into needs of communities. Methods A pilot study using in-depth interviews with small convenience sample former ex-Army residents Tameside. Framework analysis was used identify group themes arising from data. This conducted Consolidated...
Dr. Ursus won't last long allowing his practice to run him.[1][1] There must be an appropriate balance of work and relaxtation. A doctor who wants go the distance prepare himself or herself in same way that athletes train for optimal performance; this requires adequate sleep, a healthy
ABSTRACT Background The English Indices of Multiple Deprivation (IMD) is widely used as a measure deprivation geographic areas in analyses health inequalities between places. However, similarly ranked can differ substantially the underlying domains and indicators that are to calculate IMD score. These contain richer set data might be useful for classifying local authorities. Clustering methods offer techniques identify groups with similar patterns deprivation. This could insights into face...
ABSTRACT Background Human papillomavirus (HPV) is the main cause of cervical cancer and contributes to a number other cancers that affect both men women. Vaccines exist offer protection against most common cancer-causing HPV types. In England, school-based vaccination programme for girls has been in place since 2008 but vaccine coverage rates have declined its introduction. Understanding variation between schools local authorities may help inform quality improvement guide policy development...