A5070326250- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Biochemical effects in animals
- Memory and Neural Mechanisms
- COVID-19 and Mental Health
- Anesthesia and Neurotoxicity Research
- Digital Mental Health Interventions
- Plant Toxicity and Pharmacological Properties
- Alcohol Consumption and Health Effects
- Aldose Reductase and Taurine
- Long-Term Effects of COVID-19
- Diet, Metabolism, and Disease
- Youth, Drugs, and Violence
- Hematopoietic Stem Cell Transplantation
- Neuropeptides and Animal Physiology
- Animal Nutrition and Health
- Nicotinic Acetylcholine Receptors Study
- Immune Cell Function and Interaction
- Psychedelics and Drug Studies
- Nuclear Receptors and Signaling
- Retinoids in leukemia and cellular processes
- Menstrual Health and Disorders
Universidade Federal de Ciências da Saúde de Porto Alegre
2015-2025
Hospital de Clínicas de Porto Alegre
2019-2024
University of Illinois Chicago
2022-2023
Allopregnanolone (3α,5α-tetrahydroprogesterone; pharmaceutical formulation: brexanolone) is a neurosteroid that has recently been approved for the treatment of postpartum depression, promising to fill part long-lasting gap in effectiveness pharmacotherapies depressive disorders. In this review, we explore experimental research characterized antidepressant-like effects allopregnanolone, with particular focus on neurotrophic adaptations induced by preclinical studies. We demonstrate there...
The COVID-19 pandemic has brought significant challenges, including severe psychological consequences, especially for vulnerable individuals, such as those with substance use disorders. This study investigated the impact of on patterns and health in Brazilians, exploring associations sociodemographic factors to identify groups at higher risk. Data were collected online assess self-reported through Alcohol, Smoking Substance Involvement Screening Test (ASSIST), state, using Depression,...
Alcohol use disorder is an alarming health problem, and the withdrawal symptoms increase risk of relapse. We have hypothesized that taurine, a multitarget substance acting as gamma-aminobutyric acid A receptor (GABAAR) positive modulator partial inhibitor N-methyl-d-aspartate (NMDA) glutamate receptors, may reduce or modify behaviors when combined with alcohol. Therefore, we investigated effects taurine on behavior in open field test (OFT), GABAAR α2 subunit BDNF mRNA expression frontal...
Background: Across several patient cohorts recruited for recent suicidal ideation (SI), current affective disorder, and natural menstrual cycles, we have observed a dimensional (present to varying degrees) perimenstrual (PM) worsening of SI depressed mood, specifically relative an early luteal (EL) nadir. In our prior crossover trial, PM administration combined estradiol (E2) progesterone (P4) reduced this exacerbation depressive symptoms versus placebo (PBO). This three-period trial...
The outbreak of coronavirus disease 19 has led to measures social distancing and quarantine worldwide. This stressful period may lead psychological problems, including changes in substance use. In addition, sociodemographic factors are linked changed levels drug use abuse observed during the COVID-19 pandemic, which also associated with increased anxiety, depression, other disorders. Thus, aim study was investigate (i) pandemic distancing, (ii) verify those changes.A web-based...
Caffeine and alcohol are some of the most commonly used psychoactive substances in world, often concomitantly. However, little is known about effect caffeine on consumption. Here, our aim was to investigate co-exposure mixed with self-administration. Thirty-two male thirty-two female Wistar rats were randomly divided into following groups: control, (0.25 mg/mL), (10% v/v) caffeine. After one week training, animals underwent self-administration for 21 days (1 h per day) a fixed ratio 1 (FR1)....