A5103277721- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Mosquito-borne diseases and control
- Malaria Research and Control
- Insect symbiosis and bacterial influences
- Invertebrate Immune Response Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Vectors
- Neurological Complications and Syndromes
- Poxvirus research and outbreaks
- Toxoplasma gondii Research Studies
- Neurobiology and Insect Physiology Research
- CNS Lymphoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Viral-associated cancers and disorders
Tufts University
2014-2020
Harvard University
2017-2018
Developmental Studies Hybridoma Bank
2010
Imaging Center
2010
University of Iowa
2010
Texas A&M University
2010
University of Massachusetts Chan Medical School
2010
Indiana University Bloomington
2010
Buckland Hospital
1998
A hallmark property of the neurotropic alpha-herpesvirinae is dissemination infection to sensory and autonomic ganglia peripheral nervous system following an initial exposure at mucosal surfaces. The serve as latent virus reservoir source recurrent infections such cold sores (herpes simplex type I) shingles (varicella zoster virus). However, means by which these viruses routinely invade not fully understood. We report that internal virion component, pUL37 tegument protein, has a surface...
In vertebrates, sialylated glycans participate in a wide range of biological processes and affect the development function nervous system. While complexity glycosylation functional redundancy among sialyltransferases provide obstacles for revealing roles sialylation mammals, Drosophila possesses sole vertebrate-type sialyltransferase, sialyltransferase (DSiaT), with significant homology to its mammalian counterparts, suggesting that could be suitable model investigate sialylation. To explore...
ABSTRACT In cells infected with herpesviruses, two capsid-associated, or inner tegument, proteins, UL37 and UL36, control cytosolic trafficking of capsids by as yet poorly understood mechanisms. Here, we report the crystal structure N-terminal half from pseudorabies virus, an alphaherpesvirus closely related to herpes simplex viruses varicella-zoster virus. The structure—the first for any tegument protein—reveals elongated molecule a complex architecture rich in helical bundles. To explore...
A case is described of acute cerebellar symptoms as the presenting features Epstein-Barr virus (EBV) infection. Cerebellar encephalitis discussed with particular reference to EBV
Structural and biochemical studies of proteins require high amounts stable, purified proteins. Protein stability often depends on the buffer composition, which includes pH concentration salts or other solutes such as glycerol, hence an efficient method for identifying optimal conditions would minimize time resources used protein purification further studies. This protocol describes use Thermofluor assay, in combination with a custom 24-condition screen, to identify that increase...