A5087913701- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immune cells in cancer
- Immunotherapy and Immune Responses
Center for Excellence in Molecular Cell Science
2021-2022
Chinese Academy of Sciences
2021-2022
University of Chinese Academy of Sciences
2022
The cytoplasmic domain of PD-L1 (PD-L1-CD) regulates degradation and stability through various mechanism, making it an attractive target for blocking PD-L1-related cancer signaling. Here, by using NMR biochemical techniques we find that the membrane association PD-L1-CD is mediated electrostatic interactions between acidic phospholipids basic residues in N-terminal region. absence replacement with abolish association. Moreover, basic-to-acidic mutations also decrease cellular abundance...
Cholesterol, an essential molecule for cell structure, function, and viability, plays crucial roles in the development, progression, survival of cancer cells. Earlier studies have shown that cholesterol-lowering drugs can inhibit high expression programmed-death ligand 1 (PD-L1) contributes to immunoevasion However, regulatory mechanism surface PD-L1 abundance by cholesterol is still controversial. Here, using nuclear magnetic resonance biochemical techniques, we demonstrated directly bind...