In addition to skeletal muscle dysfunction, cancer cachexia is a systemic disease involving remodeling of nonmuscle organs such as adipose and liver. Impairment mitochondrial function associated with multiple chronic diseases. The tissue-specific control in not well defined. This study determined respiratory capacity coupling muscle, white tissue (WAT), liver colon-26 (C26) tumor-induced cachexia. Tissues were collected from PBS-injected weight-stable mice, C26 mice moderate (10% weight...

Background: Exercise training (ET) has neuroprotective effects in the hippocampus, a key brain region for memory that is vulnerable to age-related dysfunction. Objective: We investigated of ET on functional connectivity (FC) hippocampus older adults with mild cognitive impairment (MCI) and cognitively normal (CN) control group. also assessed whether ET-induced changes hippocampal FC (Δhippocampal-FC) are associated task performance (Δmemory performance). Methods: 32 (77.0±7.6 years; 16 MCI...

Aerobic training (AT) can support brain health in Alzheimer's disease (AD); however, the role of resistance (RT) AD is not well established. Aside from direct effects on brain, exercise may also regulate function through secretion muscle-derived myokines. Aims. This study examined AT and RT hippocampal BDNF IGF-1 signaling, β-amyloid expression, myokine cathepsin B triple transgenic (3xTg-AD) model AD. 3xTg-AD mice were assigned to one following groups: sedentary (Tg), aerobic trained...

Background: The hippocampus is a key brain structure that has been implicated in vascular dementia etiology and highly sensitive to changes cerebral blood flow. Brain hypoperfusion cardiovascular disease may facilitate neurodegeneration the by limiting substrate transport metabolism. While most animal studies have relied on artery occlusion lower flow, can also stem from mechanical damage resulting high flow velocity pulsatility. This study assessed, within same rodent, whether low...

Obesity may attenuate the expression of brain-derived neurotrophic factor (BDNF), thereby increasing risk cognitive dysfunction. High-intensity interval exercise (HIIE) has been shown to be as or more effective than continuous moderate-intensity (CME) in promoting BDNF normal-weight individuals. Therefore, primary purpose this study was examine whether not acute HIIE could utilized a practical model explore response obese versus subjects when compared CME. The potential relationship...

Individuals with Mild Cognitive Impairment (MCI) are at an elevated risk of dementia and exhibit deficits in cognition cortical gray matter (GM) volume, thickness, microstructure. Meanwhile, exercise training appears to preserve brain function macrostructure may help delay or prevent the onset individuals MCI. Yet, our understanding neurophysiological effects MCI remains limited. Recent work suggests that measures microstructure using diffusion imaging be sensitive early cognitive changes...

Abstract Objectives: Ample evidence suggests exercise is beneficial for hippocampal function. Furthermore, a single session of aerobic provides immediate benefits to mnemonic discrimination performance, highly hippocampal-specific memory process, in healthy younger adults. However, it unknown if alters older adults, who generally exhibit greater deterioration and deficits performance. Methods: We conducted within subject acute study 30 cognitively physically active adults underwent baseline...

Objectives: Psychosocial stressors associated with the COVID-19 pandemic may increase risk of depression and anxiety in general population. Individuals approaching or within older adulthood be especially vulnerable to these psychosocial their impact on mental health outcomes. Consequently, there is an urgent need identify protective factors for adults. The purpose present study was determine relative contribution coping flexibility (CF) two distinct strategies, forward-focused...

The well-elucidated improvement of mood immediately after exercise in older adults presumably involves adaptations emotion-processing brain networks. However, little is known about effects acute on appetitive and aversive emotion-related network recruitment adults. purpose this study was to determine the effect exercise, compared a seated rest control condition, pleasant unpleasant regional activation healthy Functional MRI data were acquired from 32 active during blocked presentations...

Abstract Skeletal muscle atrophy and dysfunction commonly accompany cardiovascular diseases such as peripheral arterial disease may be partially attributable to systemic inflammation. We sought determine whether acute inflammation in a model of hindlimb ischaemia (HLI) could affect skeletal macrophage infiltration, fibre size, or capillarization, independent the ischaemia. Eight‐week‐old C57BL/6 male mice underwent either Sham HLI surgery, were killed 1, 3, 7 days post‐surgery. Circulating...

Mannerism was the bridge between late Renaissance and Baroque 1520 1600s. This movement characterized by destabilization of compositional elements through repetition expressiveness, regardless their function. phase in history echoes a trend contemporary architecture based on functionless that constitute ‘green aesthetic’ detriment sustainable systems. Ecomannerism is conceptual vehicle to identify evaluate iconic projects are positioned ecologies practice symbols, which directly related...

The therapeutic relationship continues to be one of the most important factors in outcomes. Given place emotion definition relationship, as well demonstrated positive impact that emotional expression has on process and outcome, it stands reason studying exchange between therapist client further would warranted.This study used a validated observational coding system--the Specific Affect Coding System (SPAFF) theoretical mathematical model analyze behaviors which make up relationship....

C1q-TNF-related protein-9 (CTRP9) increases endothelial nitric oxide synthase and reduces vasoconstrictors. There is limited information regarding exercise-mediated CTRP9 in obesity. The purpose of this study was to compare high-intensity interval exercise (HIIE) continuous moderate-intensity (CME) on the response an indicator function (FMD) obese participants. Sixteen young male participants (9 7 normal-weight) participated a counterbalanced caloric equated experiment: HIIE (30 min, 4...

Se determinaron los parámetros necesarios para la elaboración de recubrimientos , sobre aceros AISI 1020, utilizando como mecanismo anclaje entre el sustrato y cerámico una aleación a base Ni, polvos utilizados fueron comerciales método deposición por aspersión con llama oxiacetilénica. Los revestimientos se analizaron EDS (espectroscopía dispersión energías, SEM (microscopía electrónica barrido), OM óptica), adherencia cuantificó bajo norma ASTM C633-08. obtenidos proyección Ni son...