A5101644927- Advanced Fluorescence Microscopy Techniques
- Nonlinear Optical Materials Studies
- Photoreceptor and optogenetics research
- Click Chemistry and Applications
- CO2 Reduction Techniques and Catalysts
- Metalloenzymes and iron-sulfur proteins
- Pelvic and Acetabular Injuries
- Metallurgy and Material Forming
- Elasticity and Material Modeling
- Electrocatalysts for Energy Conversion
- Metal Alloys Wear and Properties
- Geotechnical Engineering and Underground Structures
- Pregnancy-related medical research
- Orthopaedic implants and arthroplasty
- Advanced biosensing and bioanalysis techniques
- Powder Metallurgy Techniques and Materials
- Fatigue and fracture mechanics
- Microstructure and mechanical properties
- Spine and Intervertebral Disc Pathology
- Engineering Structural Analysis Methods
- Optical Imaging and Spectroscopy Techniques
- Synthesis of Organic Compounds
- Orthopedic Surgery and Rehabilitation
- Protein Interaction Studies and Fluorescence Analysis
- Synthesis and biological activity
Paderborn University
2024
University of Alberta
2014-2021
October University of Modern Sciences and Arts
2021
Isfahan University of Technology
2015
Alberta Hospital Edmonton
2015
Two-photon spectroscopy of fluorescent proteins is a powerful bioimaging tool. Considerable effort has been made to measure absolute two-photon absorption (TPA) for the available proteins. Being technically involved procedure, there significant variation in published experimental measurements even same protein. In this work, we present time-dependent density functional theory (TDDFT) study on isolated chromophores comparing ability four functionals (PBE0, B3LYP, CAM-B3LYP, and LC-BLYP)...
TD-DFT screening of unnatural GFP-like chromophores highlights a nitro-derivative with large TPA (two-photon absorption) that is further studied in protein enclosure by MD simulations.
Two-photon spectroscopy of fluorescent proteins is a powerful bio-imaging tool known for deep tissue penetration and little cellular damage. Being less sensitive than the one-photon microscopy alternatives, protein with large two-photon absorption (TPA) cross-section needed. Here, we use time-dependent density functional theory (TD-DFT) at B3LYP CAM-B3LYP/6-31+G(d,p) levels to screen twenty-two possible chromophores that can be formed upon replacing amino-acid Tyr66 forms red (RFP)...
Abstract The tetrameric red fluorescent protein from Discosoma sp. coral (DsRed) has previously been engineered to produce dimeric and monomeric variants with excitation emission profiles that span the visible spectrum. brightest of effectively DsRed is tdTomato—a tandem fusion a variant. Here we describe engineering brighter (RRvT), green (GGvT), green–red heterodimeric (GRvT) tdTomato variants. GRvT exhibited 99 % intramolecular FRET efficiency, resulting in long Stokes shift fluorescence....
Effective photoinduced charge transfer makes molecular bimetallic assemblies attractive for applications as active light-induced proton reduction systems. Developing competitive base metal dyads is mandatory a more sustainable future. However, the electron mechanisms from photosensitizer to catalyst in remain so far unexplored. A Fe─Co dyad that exhibits photocatalytic H
A novel series of coumarin–pyrazoline hybrids 3a–f, 4a–c and 5a–c have been synthesized tested for their antiproliferative activity against the breast cancer cell line MCF-7.
Abstract To simulate the mechanical and fracture behaviors of cancellous bone in three anatomical directions to develop an equivalent constitutive model. Microscale extended finite element method (XFEM) models a specimen were developed with directions. An appropriate abaqus macroscale model replicated behavior observed microscale models. The parameters defined based on intermediate material properties assigned nonporous same size. capability was analyzed by comparing micro- macromodels....
The objective is developing an XFEM model that capable of predicting different types fracture in the pelvic bone under various loading conditions. Previously published mechanical and failure characteristics cortical cancellous tissues were implemented assigned to intact with specified tissues. Various conditions, including combined load directions, applied acetabulum (e.g., anterior/posterior wall transverse fracture) bone. predicated maximum force at compared those acquired from previously...
The objective of our study is to develop extended finite element method models cancellous bone specimens that are capable accurately predicting the onset and propagation cracks under mechanical loading. In order do so, previously published three-point bending test results a single trabecula were replicated using two different approaches, namely, elastic-plastic-fracture elastic-fracture considered configurations elasto-plastic properties from which best approach fit experimental data was...
Abstract The integrity decisions for cracked pipelines can be made based on the conventional Finite Element Method (FEM). However, it is extremely time-consuming due to requirement of remeshing continuously conform geometric discontinuities as crack propagates. more recently developed Extended (XFEM) provides a robust approach in which propagate through finite element analysis mesh and thus alleviates remeshing. current criteria initiation propagation XFEM framework have not been calibrated...
Effective photoinduced charge transfer makes molecular bimetallic assemblies attractive for applications as active light induced proton reduction systems. For a more sustainable future, development of competitive base metal dyads is mandatory. However, the electron mechanisms from photosensitizer to catalyst in remain so far unexplored. We study Fe-Co dyad that exhibits photocatalytic H2 production activity using femtosecond X-ray emission spectroscopy, complemented by ultrafast optical...