A5033522944- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Adipose Tissue and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Sirtuins and Resveratrol in Medicine
- Neural dynamics and brain function
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neuroscience and Music Perception
- Genetic Associations and Epidemiology
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Pharmacological Effects and Toxicity Studies
- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- Bipolar Disorder and Treatment
- Omental and Epiploic Conditions
- Endometriosis Research and Treatment
- Sleep and related disorders
- Histone Deacetylase Inhibitors Research
University of Pittsburgh
2019-2023
Nova Southeastern University
2023
University of Pittsburgh Medical Center
2021
BackgroundPrevalence rates of opioid use disorder (OUD) have increased dramatically, accompanied by a surge overdose deaths. While dependence has been extensively studied in preclinical models, an understanding the biological alterations that occur brains people who chronically opioids and are diagnosed with OUD remains limited. To address this limitation, RNA sequencing was conducted on dorsolateral prefrontal cortex nucleus accumbens, regions heavily implicated OUD, from postmortem...
Significance Circadian rhythms are important in nearly all aspects of brain function. We previously identified diurnal transcripts human cortical regions that impacted aging and schizophrenia. Here, we identify transcript expression across the dorsal ventral striatum subjects without psychiatric or neurological disorders. find some to be rhythmic only select regions. also distinct phase relationships suggesting waves specific cellular processes striatum. These studies establish a temporal...
Individuals suffering from mood and anxiety disorders often show significant disturbances in sleep circadian rhythms. Animal studies indicate that rhythm disruption can cause increased depressive- anxiety-like behavior, but the underlying mechanisms are unclear. One potential mechanism to explain how rhythms contributing is through dysregulation of suprachiasmatic nucleus (SCN) hypothalamus, known as "central pacemaker." To investigate role SCN regulating behavior mice, we chronically...
The circadian transcription factor neuronal PAS domain 2 (NPAS2) is linked to psychiatric disorders associated with altered reward sensitivity. expression of <i>Npas2</i> preferentially enriched in the mammalian forebrain, including nucleus accumbens (NAc), a major neural substrate motivated and behavior. Previously, we demonstrated that downregulation NPAS2 NAc reduces conditioned behavioral response cocaine mice. We also showed dopamine receptor 1 containing medium spiny neurons (D1R-MSNs)...
Abstract Opioid craving and relapse vulnerability is associated with severe persistent sleep circadian rhythm disruptions. Understanding the neurobiological underpinnings of rhythms opioid use disorder (OUD) may prove valuable for developing new treatments addiction. Previous work indicated molecular disruptions in human brain OUD, highlighting synaptic alterations dorsolateral prefrontal cortex (DLPFC) nucleus accumbens (NAc)—key regions involved cognition reward, heavily implicated...
Substance use disorders are associated with disruptions to both circadian rhythms and cellular metabolic state. At the molecular level, clock state may be interconnected through interactions nicotinamide adenine dinucleotide (NAD+ )-dependent deacetylase, sirtuin 1 (SIRT1). In nucleus accumbens (NAc), a region important for reward, SIRT1 transcription factor neuronal PAS domain protein 2 (NPAS2) highly enriched, regulated by cofactor NAD+ . Substances of abuse, like cocaine, greatly disrupt...
Abstract Opioid craving and relapse vulnerability is associated with severe persistent sleep circadian rhythm disruptions. Understanding the neurobiological underpinnings of rhythms opioid use disorder (OUD) may prove valuable for developing new treatments addiction. Previous work indicated molecular disruptions in human brain OUD, highlighting synaptic alterations dorsolateral prefrontal cortex (DLPFC) nucleus accumbens (NAc)—key regions involved cognition reward, heavily implicated...
Abstract Circadian rhythms are commonly disrupted in individuals with depression and/or anxiety disorders. Animal studies indicate that circadian rhythm disruption can cause increased depressive and anxiety-like behavior, but the underlying mechanisms unclear. Currently, there is conflicting evidence as to whether master pacemaker brain, suprachiasmatic nucleus (SCN), plays a key role regulating psychiatric-related behavior. To investigate of SCN behavior mice, we directly manipulated neural...
Abstract Background Prevalence rates of opioid use disorder (OUD) have increased dramatically, accompanied by a surge overdose deaths. While dependence has been extensively studied in preclinical models, an understanding the biological alterations that occur brains people who chronically opioids and are diagnosed with OUD remains limited. To address this limitation, RNA-sequencing (RNA-seq) was conducted on dorsolateral prefrontal cortex (DLPFC) nucleus accumbens (NAc), regions heavily...