A5040943468- Protein Structure and Dynamics
- Dietetics, Nutrition, and Education
- Enzyme Structure and Function
- Traumatic Brain Injury Research
- Machine Learning in Bioinformatics
- Cardiomyopathy and Myosin Studies
- Stroke Rehabilitation and Recovery
- Cardiac Arrest and Resuscitation
- Scientific Computing and Data Management
- Genetic diversity and population structure
- Opioid Use Disorder Treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Computational Drug Discovery Methods
- Liver physiology and pathology
- Ion Transport and Channel Regulation
- Lysosomal Storage Disorders Research
- Substance Abuse Treatment and Outcomes
- Lipid Membrane Structure and Behavior
- Software System Performance and Reliability
- Trace Elements in Health
- Autophagy in Disease and Therapy
- RNA and protein synthesis mechanisms
- Therapeutic Uses of Natural Elements
- Viral Infections and Immunology Research
- Erythrocyte Function and Pathophysiology
Blue Cross Blue Shield Association
2020
University of Reading
2015-2019
University of Oxford
2016-2017
University of Hull
2015
University of Wales
1987-1989
Lysosomal storage diseases (LSDs) often manifest with severe systemic and central nervous system (CNS) symptoms. The existing treatment options are limited have no or only modest efficacy against neurological manifestations of disease. We demonstrate that recombinant human heat shock protein 70 (HSP70) improves the binding several sphingolipid-degrading enzymes to their essential cofactor bis(monoacyl)glycerophosphate in vitro. HSP70 reversed lysosomal pathology primary fibroblasts from 14...
IntFOLD is an independent web server that integrates our leading methods for structure and function prediction. The provides a simple unified interface aims to make complex protein modelling data more accessible life scientists. designed be intuitive set of quantitative data, so 3D results can viewed on single page interpreted by non-expert modellers at glance. only required input the amino acid sequence target protein. Here we describe major performance user updates server, which comprises...
Our aim in CASP12 was to improve our Template-Based Modeling (TBM) methods through better model selection, accuracy self-estimate (ASE) scores and refinement. To meet this aim, we developed two new automated methods, which used score, rank, upon the provided server models. Firstly, ModFOLD6_rank method, for improved global Quality Assessment (QA), ranking detection of local errors. Secondly, ReFOLD method fixing errors iterative QA guided For predictions IntFOLD4-TS protocol, integrates...
The opioid epidemic is raging within the COVID-19 pandemic, with more than 40 states reporting increases in opioid-related overdoses and deaths. has disrupted health care services, disproportionately affecting […]
Transitions in sexual system and reproductive mode may affect the course of sex chromosome evolution, for instance by altering strength sexually antagonistic selection. However, there have been few studies chromosomes systems where such transitions documented. The European tadpole shrimp, Triops cancriformis, has undergone a transition from dioecy to androdioecy (a hermaphrodites males coexist), offering an excellent opportunity test impact this on evolution chromosomes. To identify...
Background: To date, no one has prospectively evaluated yoga intervention-induced changes in brain structure or function adults with acquired injuries (ABI). Thus, this study was conducted to test the feasibility of acquiring neuroimaging data from ABI before and after a intervention. Methods: This single-arm intervention that included 12 chronic (i.e., greater than 6 months post-injury) self-reported limitations balance. Neuroimaging were yoga. The completed once per week for eight weeks....
<p><strong>[para. 1]: "Dietetics is a diverse profession with commitment to, and tradition of, enhancing health, broadly defined, through diet food. </strong>We recognize the hard work undertaken by dietetic professionals of past present who continue to innovatively shape reshape from its roots in home economics incorporation contemporary perspectives on health. While recognizing multiple meanings food power nourish heal, we acknowledge that more than mere sum constituent...
Heart failure is defined as a progressive condition in which the heart unable to pump enough blood meet body's needs for oxygen and nutrients. A common cause of due genetic mutations cytoskeletal proteins required contractile activity and/or mechanosensing. These include such CSRP3 or muscle LIM protein (MLP) number these result cardiomyopathy, sudden death. MLP small comprised 194 amino acids found Z‐disk myofilaments cardiac myocytes. functions signalling molecule linking mechanosensing...
Muscle LIM protein (MLP) is a member of the cysteine‐rich family, localising predominantly to Z‐disk myofilaments in cardiac myocytes. MLP mechanosensor and functions through its translocation nucleus from protein‐protein interactions cytoplasm. Mechanosensing enables heart adapt appropriately alterations hemodynamic load, whilst mutations gene lead cardiomyopathy failure. contains two domains each consisting double zinc‐finger motif. Rather than interacting with DNA, mediate associated...
<p><strong>[para. 1]: "Dietetics is a diverse profession with commitment to, and tradition of, enhancing health, broadly defined, through diet food. </strong>We recognize the hard work undertaken by dietetic professionals of past present who continue to innovatively shape reshape from its roots in home economics incorporation contemporary perspectives on health. While recognizing multiple meanings food power nourish heal, we acknowledge that more than mere sum constituent...