A5034340651- Metabolomics and Mass Spectrometry Studies
- Ovarian function and disorders
- Heart Rate Variability and Autonomic Control
- Functional Brain Connectivity Studies
- Phytoestrogen effects and research
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetic Foot Ulcer Assessment and Management
- Circadian rhythm and melatonin
- Ginseng Biological Effects and Applications
- Muscle metabolism and nutrition
- Hormonal and reproductive studies
- Liver Disease Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Diabetes and associated disorders
- Diet and metabolism studies
- Nutrition, Health and Food Behavior
- Obesity, Physical Activity, Diet
- Cardiovascular Disease and Adiposity
- Urinary Bladder and Prostate Research
- Parkinson's Disease Mechanisms and Treatments
- IL-33, ST2, and ILC Pathways
- Eating Disorders and Behaviors
- Tuberculosis Research and Epidemiology
- Diagnosis and treatment of tuberculosis
Iuliu Hațieganu University of Medicine and Pharmacy
2017-2025
Clinical Emergency Hospital Bucharest
2020
Background/Objectives: Lifestyle factors, sociodemographic determinants, and dietary patterns play an important role in shaping genitors fetal health. This study aimed to identify investigate the social determinants of health lifestyle components associated with body mass index (BMI) a population reproductive age. Methods: A cross-sectional online survey was conducted between March 2021 February 2022. Self-reported data on age, weight, height, medical history were collected. Results: total...
Polycystic ovary syndrome (PCOS), characterized by oligo-anovulation and androgen excess is considered a high-risk condition for metabolic disorders. Herein, untargeted metabolomics analysis was applied to women with PCOS, aiming provide deeper insights into lipidomics biomarkers signature of better diagnosis management. This cross-sectional study in which 15 Caucasian PCOS healthy, age-matched were enrolled. Lipidomics performed using Ultra-High Performance Liquid Chromatography-Quadrupole...
This research aimed to explore the relation of social jetlag (SJL) with perceived appetite, and hormones involved in hunger regulation healthy subjects free-living conditions (study registration number: ACTRN12618001182280). Eighty normally diurnally active men women were enrolled 4 study groups according presence SJL sleep deprivation (2 or without deprivations 2 deprivation) matched 1:1:1:1 for age, gender, body mass index. Appetite was assessed fasting state, by measuring acylated ghrelin...
Background . sST2 represents a useful biomarker for the diagnosis and prognosis of patients with heart failure, but limited data is available on its role in hypertension. The aim this study to evaluate short-term value an unfavorable outcome hypertensive patients. Methods This was prospective observational which enrolled 80 hypertension, who were followed one year. All underwent clinical, laboratory (including sST2), echocardiographic assessment at baseline. grouped according cardiovascular...
The objective of this prospective study was to assess the correlation between carotid intima-media thickness at common (CIMTc) and bifurcation (CIMTb) level, hepatic fat accumulation, obesity phenotypes.Two hundred obese adults, in which CIMTc CIMTb determined, were included. According body mass index (BMI) presence metabolic syndrome (MetS), patients classified as metabolically healthy (MHO, without MetS) unhealthy (MUHO, with MetS). MHO further MHO1 (obese increased waist circumference)...
This research aimed to explore in free-living condition, healthy normal weight subjects, the effect of social jetlag (SJL) and sleep deprivation on resting-state brain connectivity synchronization, as assessed by fMRI, their association with appetite. We found abnormal local functional synchronization resting-state, depicted altered regional homogeneity (ReHo), posterior cerebellar regions subjects SJL and/or deprivation. also intrinsic global patterns, degree centrality (DC), these...
Heart failure is a significant healthcare problem, because of its impact at the individual and populational level, through multiple rehospitalizations increased morbi-mortality.At multidimensional this clinical condition treatment on patients' daily lives reflected in quality life (QoL).QoL needs to be accurately measured, it's related high hospitalization mortality rates provides valuable information that cannot directly obtained using clinical, biological or imaging measurements.For these...
The aim of the paper is to detect insulin resistance (IR) biomarkers via metabolomics. It important understand PCOS pathophysiology, diagnosis measures and, subsequently, improve treatment type and time IR in PCOS. In most cases, almost half women with have which triggered by inflammation, glucotoxicity lipotoxicity. this work was conducted a systematic review all papers that used metabolomics for detecting women. exclusion criteria were: reviews, study population bellow 18 years age,...
Objective.Rheumatoid arthritis (RA), a chronic autoimmune disease which primarily affects the joints, is associated with various cardiometabolic comorbidities.These comorbidities, particularly metabolic syndrome, exert an altered secretion of proinflammatory adipokines that increase cardiovascular risk in rheumatic diseases.Leptin and resistin are two most important intensely-studied adipocytokines.Increased serum levels both leptin RA patients have been previously reported but results...
To evaluate the changes in quality of life (QOL), diabetic neuropathy (DN) and amputations over 4 years patients with diabetes.In 2012, 25,000 Romanian-translated Norfolk QOL-DN self-administered questionnaires were distributed during a cross-sectional study. Between March-December 2016, all identified from 2012 cohort enrolled this follow-up study completed questionnaire; suffered since recorded. The influence age duration diabetes (DD) on delta QOL scores (defined as differences between...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
The aim of the paper is to detect insulin resistance (IR) biomarkers via metabolomics. It important understand PCOS pathophysiology, diagnosis measures and, subsequently, improve treatment type and time IR in PCOS. In most cases, almost half women with have which triggered by inflammation, glucotoxicity lipotoxicity. this work was conducted a systematic review all papers that used metabolomics for detecting women. exclusion criteria were: reviews, study population bellow 18 years age,...
Abstract Introduction : Although obesity and its biomarkers have been intensively studied, little is known about the metabolomic signature of visceral adiposity independent insulin resistance that frequently accompanies increased levels fat. Our study aimed to investigate specific changes in amino acid (AA) as resistance, healthy subjects. Methods Forty-two adult women were included this cross-sectional study. Serum samples analyzed by AAs targeted metabolomics according their fat area...
Abstract The prevalence of diabetes mellitus (DM) has rapidly increased over the last decades, reaching epidemic magnitudes, particularly in lowand middle-income countries. Point-of-care (POC) technology enables decision making near or at site patient care. Portable blood glucose meters and HbA1c testing are used by healthcare provider millions patients with to monitor safety effectiveness treatment. However, POC capillary not recommended for diagnosis. Rather, they have been screening...
Lower urinary tract symptoms (LUTS) are commonly reported by men and women with diabetes may share a common pathogenic mechanism diabetic peripheral neuropathy (DPN). We aimed to evaluate associations between DPN self-reported LUTS in cohort of Romanian patients phenotyped for the Michigan Neuropathy Screening Instrument (MNSI). Clinical was defined as MNSI exam score >2; symptomatic questionnaire ≥4. assessed validated American Urological Association Symptom Index 0-7 none/mild ≥8...
Poor oral health (OH) manifested mainly as gingivitis/periodontitis is emerging a serious diabetes complication. Recent reports suggest that poor OH may share pathogenic mechanisms with diabetic neuropathy (DN). We previously reported high prevalence of in large Romanian cohort >1300 participants phenotyped for and DN 2016, particularly among DN. This follow-up study aimed to further evaluate associations between this over time. was assessed the Michigan Neuropathy Scoring Instrument...