A5062034700- Phytochemicals and Antioxidant Activities
- Asthma and respiratory diseases
- Phytochemical and Pharmacological Studies
- Antioxidant Activity and Oxidative Stress
- Medicinal plant effects and applications
- Pharmacological Effects of Natural Compounds
- Essential Oils and Antimicrobial Activity
- Allergic Rhinitis and Sensitization
- Vitamin D Research Studies
- Nigella sativa pharmacological applications
- Curcumin's Biomedical Applications
- Liver Disease Diagnosis and Treatment
- Bioactive Compounds and Antitumor Agents
- Acute Ischemic Stroke Management
- Probiotics and Fermented Foods
- Biochemical effects in animals
- Phytochemistry and Biological Activities
- Drug-Induced Hepatotoxicity and Protection
- Adipokines, Inflammation, and Metabolic Diseases
- Infectious Diseases and Mycology
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Diet, Metabolism, and Disease
- Cardiac Ischemia and Reperfusion
- Ginger and Zingiberaceae research
Iuliu Hațieganu University of Medicine and Pharmacy
2015-2025
University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
2011-2024
Academy of Romanian Scientists
2024
Weatherford College
2023
Babeș-Bolyai University
2022
University of Agricultural Sciences, Dharwad
2011-2013
Victor (Japan)
2013
Wageningen University & Research
2013
Spitalul Clinic Județean de Urgență Cluj-Napoca
1987
Curcumin has anti-inflammatory, antioxidative, anticarcinogenic, and cardiovascular protective effects. Our study is aimed at evaluating the effects of pretreatment with curcumin nanoparticles (CCNP) compared to conventional (CC) on isoproterenol (ISO) induced myocardial infarction (MI) in rats. Fifty-six Wistar-Bratislava white rats were randomly divided into eight groups seven each. given by gavage three different doses (100 mg/kg body weight (bw), 150 bw, 200 bw) for 15 days. The MI was...
Curcumin from Curcuma longa is a nutraceutical compound reported to possess strong antioxidant activity that makes it candidate for use in counteracting oxidative stress-induced damage. The effect of pre-treatment with curcumin nanoparticles (nC) compared conventional (Cs) on blood pressure, electrocardiogram, and biological changes isoproterenol (ISO)-induced myocardial infarction (MI) rats had been investigated. Cs doses 150 200 mg/kg bw all nC (100, bw) significantly reduced heart rate...
Honey is abundant in bioactive compounds, which demonstrate considerable therapeutic effects, particularly on oxidative stress and inflammation. This work sought to evaluate the antioxidant mechanisms of Manuka honey (MH) Ohia Lehua (OLH), correlating them with phytochemical analyses a rat model experimentally induced The identification polyphenolic compounds extracts was carried out using HPLC-ESI MS. extracts' activity evaluated vitro through DPPH, FRAP, H2O2, NO scavenging assays, while...
Grape pomace (GP), the residue left after grape pressing in winemaking, is rich polyphenols, including flavonoids, tannins, and phenolic acids, which have antioxidant anti-inflammatory properties. The present study aimed to evaluate cardioprotective effects of white (WGP) extract two concentrations polyphenols (795 mg from WGP/kg body weight (bw) 397.5 bw)), on isoproterenol (ISO)-induced myocardial infarction (MI), focusing its effects. White administration for 14 days offered a...
ABSTRACT Introduction Sea buckthorn ( Hippophaë rhamnoides L.) is known to be rich in many bioactive compounds (such as vitamins, phenolics, carotenoids) important for human health and nutrition. Among the berries leaves contain a wide range of flavonols that are good quality authenticity biomarkers. Objective To compare composition main Romanian sea berry leaf varieties identify specific biomarkers contribute sample differentiation among varieties. Material methods Six cultivated ssp....
We have investigated the cardio-protective effects of pretreatment with curcumin nanoparticles (CUN) compared to conventional (CUS) on changes in oxidative stress parameters and inflammatory cytokine levels during induced acute myocardial infarction (AMI) rats diabetes mellitus (DM). DM was streptozotocin, AMI isoproterenol. Eight groups seven Wister Bratislava were included study. The N-C normal control group, AMI-C group AMI, DM-C DM, DM-AMI-C AMI. All four received saline solution orally...
Acetaminophen (APAP) is one of the most used analgesics and antipyretic agents in world. Intoxication with APAP main cause acute liver toxicity both US Europe. Spore-forming probiotic bacteria have ability to resist harsh gastric intestinal conditions. The aim this study was investigate possible protective effect Bacillus (B) species (sp) spores (B. licheniformis, B. indicus, subtilis, clausii, coagulans) against hepatotoxicity induced by rats. A total 35 rats were randomly divided into...
Accurate prediction of progression in subjects at risk Alzheimer's disease is crucial for enrolling the right clinical trials. However, a prospective comparison state-of-the-art algorithms predicting onset and currently lacking. We present findings "The Disease Prediction Of Longitudinal Evolution" (TADPOLE) Challenge, which compared performance 92 from 33 international teams future trajectory 219 individuals disease. Challenge participants were required to make prediction, each month 5-year...
Background: Taraxacum officinale (TO) or dandelion has been frequently used to prevent treat different liver diseases because of its rich composition in phytochemicals with demonstrated effect against hepatic injuries. This study aimed investigate the possible preventing ethanolic TO root extract (TOERE) on a rat experimental acute chronic failure (ACLF) model. Methods: Chronic (CLF) was induced by human serum albumin, and ACLF CLF D-galactosamine lipopolysaccharide (D-Gal-LPS). Five groups...
The present study aims to compare the oxidative stress biomarkers, pro-inflammatory cytokines, and histological changes induced by three cardiovascular risk factors, namely, hypertension, dyslipidemia, type 1 diabetes mellitus. Hypertension was with 40 mg/kg body weight (b.w.) of N omega-nitro-L-arginine-methyl (L-NAME) administered orally. Dyslipidemia administration a diet high cholesterol (2%) content. Diabetes mellitus intraperitoneal single dose streptozocin (65 mg/kg). Malondialdehyde...
This study aimed to investigate the antioxidant and anti-inflammatory activities mechanism of Artemisia dracunculus (A. dracunculus) abrotanum abrotanum) ethanol extracts in acute rat inflammation induced Wistar male rats with turpentine oil. The characterization polyphenolic compounds was conducted using UV–Vis Fourier-transform infrared spectroscopy high-performance liquid chromatography coupled mass spectrometry techniques. activity evaluated vitro by DPPH, FRAP, H2O2, NO scavenging tests...
A growing interest in using Nigella sativa oil (NSO) the prevention or treatment of several cardiovascular diseases has prompted this study. The research aims to investigate effect NSO on cardiac damage after long-term administration induced myocardial infarction (MI) rats.
Oxidative damages to the retinal pigment epithelium (RPE) have been suggested play a key role in pathogenesis of age-related macular degeneration. trans-Resveratrol (3,4',5-trihydroxystilbene) is nonflavonoid dietary polyphenol with various pharmacological effects, including antioxidant activity. The purpose this study was evaluate potential protective effect resveratrol against hydrogen peroxide induced oxidative stress cultured human RPE cells.Human D407 cells were pretreated at 3...
Fourier Transform Infrared (FTIR) spectroscopy in combination with chemometrics were applied for the quality control of 26 fruit brandies made by traditional technology Romania. Firstly, identification and quantitative evaluation methanol ethanol such samples, 4 mixtures standard solutions a spiked sample fingerprinted 1200 - 950 cm-1 FTIR spectral range, identifying specific wavelength 1020 1112 methanol, 1047 1087 ethanol. Then, spectra all brandy samples range 3500 750 was registered...
Trametes species represents a rich source of nutritive compounds with important pharmacological properties like antioxidant, antiinflammatory and anti-cancer properties. However, factors genetic background, harvesting period, geographic location, climatic conditions others are influencing the biosynthesis bioactive compounds, their fingerprint concentration. The aim this study was to determine antioxidant capacity, total phenolic flavonoids content two mushroom species, namely Tramestes...
Nigella sativa (NS) has been used for centuries in various inflammatory conditions because of its anti-inflammatory and antioxidant activities. The study aimed to evaluate the anti-inflammatory, antinociceptive activity oil (NSO) two models acute (carrageenan-induced) sub-acute inflammation (complete Freund’s adjuvant induced) rats. Materials Methods: NSO was administered orally 1, 2 4 mL/kg phase. For subacute phase, mL/kg, 7 days before or after induction, association with diclofenac 5...
The present study evaluated the anti-inflammatory and analgesic effects of conventional curcumin (cC) nanoparticles (nC) associated with diclofenac sodium (D) in experimental acute inflammation (AI) induced by carrageenan administration. Seven groups eight randomly selected Wistar-Bratislava white rats were evaluated. One group was control (C), AI other six groups. treated saline solution, AID D, AIcC200 AInC200 cC nC, respectively, while AIcC200D AInC200D both D. Conventional curcumin, D...