A5030773640- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Cell Adhesion Molecules Research
- Pickering emulsions and particle stabilization
- Rheumatoid Arthritis Research and Therapies
- Aerosol Filtration and Electrostatic Precipitation
- Plant-Derived Bioactive Compounds
- Collagen: Extraction and Characterization
- Lower Extremity Biomechanics and Pathologies
- Infrared Thermography in Medicine
- Surface Modification and Superhydrophobicity
- Wound Healing and Treatments
University of Freiburg
2020-2022
Osteoarthritis (OA) is a joint disease affecting millions of patients worldwide. During OA onset and progression, the articular cartilage destroyed, but underlying complex mechanisms remain unclear. Here, we uncover changes in thickness collagen fibers their composition at OA. For explants from knee joints patients, find that type I collagen-rich fibrocartilage-like tissue was formed macroscopically intact cartilage, distant lesions. Importantly, number thick (>100 nm) has decreased early...
ObjectiveClinical trials for osteoarthritis (OA), the leading cause of global disability, are unable to pinpoint early, potentially reversible disease with clinical technology. Hence, disease-modifying drug candidates cannot be tested early in disease. To overcome this obstacle, we asked whether OA-pathology detection is possible current technology.MethodsWe determined relationship between two sensitive OA markers, atomic force microscopy (AFM)-measured human articular cartilage (AC) surface...
Atomic force microscopy (AFM) has become a powerful tool for the characterization of materials at nanoscale. Nevertheless, its application to hierarchical biological tissue like cartilage is still limited. One reason that such samples are usually millimeters in size, while AFM delivers much more localized information. Here combination and fluorescence presented where features on millimeter sized sample selected by micrometer scale then mapped down nanometer precision under native conditions....
Abstract The development of multifunctional biomaterials as both tissue regeneration and drug delivery devices is currently a major focus in biomedical research. Tannic Acid (TA), naturally occurring plant polyphenol, displays unique medicinal abilities an antioxidant, antibiotic, anticancer agent. TA has applications acting crosslinker polymer hydrogels improving thermal stability mechanical properties. We have developed injectable cell seeded collagen beads crosslinked with for breast...