A5033381935- Child Abuse and Related Trauma
- Restraint-Related Deaths
- Homicide, Infanticide, and Child Abuse
- Neonatal and fetal brain pathology
- Muscle Physiology and Disorders
- Child Abuse and Trauma
- Traumatic Ocular and Foreign Body Injuries
- Neurosurgical Procedures and Complications
- Autopsy Techniques and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Fetal and Pediatric Neurological Disorders
- Neuroscience of respiration and sleep
- Cardiomyopathy and Myosin Studies
- Cerebrospinal fluid and hydrocephalus
- Genetic Neurodegenerative Diseases
- Ethics and Legal Issues in Pediatric Healthcare
- Spinal Dysraphism and Malformations
- Neurological and metabolic disorders
- Connective tissue disorders research
- Neonatal Respiratory Health Research
- Migraine and Headache Studies
- Peripheral Neuropathies and Disorders
- Infectious Encephalopathies and Encephalitis
- Child and Adolescent Health
- Neurological disorders and treatments
John Radcliffe Hospital
2013-2025
University of Oxford
2004-2025
Oxford University Hospitals NHS Trust
2004-2013
University College London
2008-2012
Great Ormond Street Hospital
2008-2012
Robert Jones and Agnes Hunt Orthopaedic Hospital
2012
Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust
2012
Royal Children's Hospital
2012
Murdoch Children's Research Institute
2012
University of Florence
2012
ABSTRACT Aim The primary aim was to investigate the incidence, birth characteristics, and timing of diagnosis cephalhaematoma (CH). secondary explore associations between CH complications during neonatal period infancy. Methods This is a nationwide population‐based register study infants (< 12 months) born in Sweden from 1997 2018. Information retrieved health registers Swedish National Board Health Welfare. Cases were with birth‐related CH. Results comprises 2930 incidence 2.2 per 1000...
Wistar rats, eight days old, were subjected to permanent bilateral forebrain ischemia, followed by hypoxia for 15 minutes. A cerebral infarct, mainly involving the neocortex, hippocampus, amygdala, striatum and subcortical white matter was produced. Neurons glia showing punctate chromatin condensation karyorrhectic cells observed 12 hours after hypoxia-ischemia. Their number increased during first two recruitment of with degenerating nuclei occurred until day five. In situ labeling nuclear...
<h3>Background and objective</h3> Historically, the diagnosis of sporadic inclusion body myositis (IBM) has required demonstration presence a number histopathological findings on muscle biopsy—namely, rimmed vacuoles, an inflammatory infiltrate with invasion non-necrotic fibres (partial invasion) amyloid or 15–18 nm tubulofilamentous inclusions (Griggs criteria). However, biopsies many patients clinically typical IBM do not show all these findings, at least presentation. We compared clinical...
Abstract Maturation of the human fetal brain should follow precisely scheduled structural growth and folding cerebral cortex for optimal postnatal function 1 . We present a normative digital atlas maturation based on prospective international cohort healthy pregnant women 2 , selected using World Health Organization recommendations standards 3 Their fetuses were accurately dated in first trimester, with satisfactory neurodevelopment from early pregnancy to years age 4,5 The was produced...
Abstract Objective To investigate seven congenital myopathy patients from six families: one French Gypsy, Spanish four British Pakistanis, and Indian. Three required mechanical ventilation birth, five died before 22 months, is ventilator‐dependent, but one, at 30 sitting with minimal support. All parents were unaffected. Methods The α‐skeletal muscle actin gene (ACTA1) was sequenced. Available biopsies investigated by standard histological electron microscopic techniques. expression of...
Objectives To analyse subdural haemorrhage (SDH) during infancy in Sweden by incidence, SDH category, diagnostic distribution, age, co-morbidity, mortality, and maternal perinatal risk factors; its association with accidents diagnosis of abuse. Methods A Swedish population-based register study comprising infants born between 1997 2014, 0–1 years diagnosed SDH-diagnoses according to the (International Classification Diseases, 10th version (ICD10), retrieved from National Patient Register...
Nemaline myopathy, known to be caused by mutations in 7 genes, including skeletal muscle α-actin ( ACTA1 ),1 is characterized weakness, hypotonia, and nemaline rods biopsy. Here we report a patient with but the opposite phenotype of hypercontractility. ### Case report. The John Radcliffe Hospital ethics review board approved study. The first child nonconsanguineous European parents presented at 6 weeks age an apneic episode thought due bilateral strangulated inguinal hernias umbilical...
Sturge-Weber syndrome (SWS) is frequently associated with neurologic complications such as seizures, so diagnosing this condition has important implications for patient management. The purpose of study was to report unusual neuroimaging findings in patients facial port-wine stain (PWS) and clinically suspected SWS.Cranial MR imaging reviewed all children involving the upper face eyelids who were referred Great Ormond Street Hospital between 2003 2007 investigation SWS. Patients excluded from...
To describe a homogeneous subtype of periventricular nodular heterotopia (PNH) as part newly defined malformation complex.Observational study including review brain MRI and clinical findings cohort 50 patients with PNH in the temporo-occipital horns trigones, mutation analysis FLNA gene, anatomopathologic fetal brain.There were 28 females 22 males. All sporadic exception an affected mother son. Epilepsy occurred 62%, cerebellar signs 56%, cognitive impairment autism 12%. Seventy percent...
Severe, too many to count retinal hemorrhages (RH) in infants have been associated with abusive head trauma, but can occur short falls. An 8-month-old male fell backward from a height of 26 cm, landing on his buttocks then hitting the back vinyl floor. The fall was videotaped. Acute subdural were found along extensive, intra-RH both eyes. Falls small heights occiput lead extensive RH type often trauma.
To determine specific cell types and pathways involved in calcification of the developing brain.We examined detailed histopathology samples from 28 autopsied brains aged 22 weeks' gestation to 14 years. The were selected because they showed associated with a range different diseases. Samples routine stains as well show markers for endothelium macrophages.Our observations indicate that develops via two main pathways: dystrophic vascular. Dystrophic results membrane disruption uncontrolled...
SUMMARY An infant with dysmorphic features was born to an epileptic mother who had taken phenytoin and sodium valproate throughout pregnancy. The began have intractable seizures 10 minutes after delivery, retrospective reports from the suggested they may occurred in utero . Ultrasound examination of brain showed a very wide subarachnoid space CT confirmed cerebral cerebellar underdevelopment. died at three days age autopsy revealed small neocerebellar hypoplasia. This case might represent...
In this study, the authors performed deep brain stimulation (DBS) of subgenual anterior cingulate cortex (SACC) in a patient with history bipolar disorder. After right thalamic stroke, intractable depression without mood elevation or mixed state developed patient. He underwent bilateral SACC DBS and died 16 months afterwards. Anatomical connections were studied preoperatively postmortem using diffusion tractography (DT). A comparison vivo high resolution ex connectivity patterns was as...