A5061659704- Computational Drug Discovery Methods
- Synthesis and biological activity
- Tryptophan and brain disorders
- Histone Deacetylase Inhibitors Research
- Advancements in Transdermal Drug Delivery
- Protein Degradation and Inhibitors
- Ginseng Biological Effects and Applications
- Malaria Research and Control
- Inflammasome and immune disorders
- Berberine and alkaloids research
- Ocular Surface and Contact Lens
- Bioactive natural compounds
- Peptidase Inhibition and Analysis
- Advanced Drug Delivery Systems
- Cholinesterase and Neurodegenerative Diseases
Manipal Academy of Higher Education
2024
Government Medical College
2020-2021
Despite considerable improvement in therapy and diagnosis, brain tumors remain a global public health concern. Among all tumors, 80% are due to Glioblastoma. The average survival rate of patient once diagnosed with glioblastoma is 15 months. Lately, the role peptidase enzymes, especially Neprilysin, neutral endopeptidase, gaining attention for its tumor growth regulation. Neprilysin expressions positively correlated several including GBM reduced expression NEP protein associated pathogenesis...
Sickness behaviour, a set of behavioural changes associated with neuroinflammation, is expressed as decreased mobility and depressed behaviour. Activation AMP‐activated protein kinase (AMPK) reported to regulate inflammation in conditions such Alzheimer traumatic brain injury. Metformin, an antidiabetic agent acting via AMPK activation, possesses anti‐inflammatory properties. Similarly, the activities berberine could be partially attributed its ability activate AMPK. In this study, we...
Abstract Malaria is a communicable disease which caused by protozoan's mainly Plasmodium species ( P. falciparum , ovale vivax malariae and knowlesi ). The increasing resistance of to available malarial drugs poses great responsibility for the researchers in field malaria. To overcome this problem resistance, study aimed design synthesize new class antimalarial agent with chalcone as main moiety. Chalcones, member flavanoid family, consist two aromatic rings 1,3‐diphenyl‐2‐propen‐1‐one...
Abstract Background The study aimed to design, synthesize and evaluate various brominated derivatives of 7-hydroxy coumarin as a new scaffold against Alzheimer’s disease by in vivo vitro models. A group three novel pyrazoles endowed with 4-methyl were designed. Among the designed compounds, single entity (D1) was selected based on docking score, which could be considered mainly for treatment disease. Three studies these compounds carried out using Argus lab4.0.1 version. According compound...