A5076582125- Gut microbiota and health
- Marine and fisheries research
- Prenatal Substance Exposure Effects
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Intensive Care Unit Cognitive Disorders
- Toxoplasma gondii Research Studies
- Clostridium difficile and Clostridium perfringens research
- Herpesvirus Infections and Treatments
- Immune Cell Function and Interaction
- Thermal Regulation in Medicine
University of Miami
2021-2024
Sylvester Comprehensive Cancer Center
2023
Intestinal immunoglobulins (Igs) maintain homeostasis between the microbiome and host. IgA facilitates microbial balance through a variety of increasingly well-described mechanisms. However, IgM IgG have less defined intestinal functions but potential to activate clearance mechanisms such as complement system receptor-mediated bacterial killing. Very little is known regarding role Igs under dysbiosis. In this review, we explore how sculpt respond We discuss IgM, IgA, IgG, individually...
IgA binding dictates the composition of intestinal microbiome and reflects dysbiotic states during chronic disease. Both pathogenic commensal bacteria differentially bind to with varying outcomes. Little is known regarding dynamics immediately following microbial dysbiosis. Recent work shows that morphine treatment rapidly induces dysbiosis within hours administration. This shift characterized by expansion a concurrent decrease in bacteria. Because this rapid shift, murine model was used...
Infection-induced T cell responses must be properly tempered and terminated to prevent immuno-pathology. Using transgenic mice, we demonstrate that intrinsic STAT1 signaling is required curb inflammation during acute infection with Toxoplasma gondii. Specifically, report mice lacking selectively in cells expel parasites but ultimately succumb lethal immuno-pathology characterized by aberrant Th1-type reduced IL-10 increased IL-13 production. We also find that, unlike STAT1, STAT3 not for...