A5103152677- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Peptidase Inhibition and Analysis
- Research on Leishmaniasis Studies
- Microfinance and Financial Inclusion
- Trypanosoma species research and implications
- Pharmacological Receptor Mechanisms and Effects
- Plant Micronutrient Interactions and Effects
- Influenza Virus Research Studies
- Salivary Gland Disorders and Functions
- Gestational Diabetes Research and Management
- Cancer Risks and Factors
- Agronomic Practices and Intercropping Systems
- Cardiovascular Issues in Pregnancy
- Agricultural Science and Fertilization
- Migraine and Headache Studies
- Oral Health Pathology and Treatment
- Spam and Phishing Detection
- Plant Reproductive Biology
- Gastrointestinal motility and disorders
- Blood donation and transfusion practices
- Pregnancy-related medical research
- Global Cancer Incidence and Screening
- Silicon Effects in Agriculture
University of Arizona
2025
Texas Southern University
2018-2023
Lovely Professional University
2022
Punjab Agricultural University
2012-2017
University of California, Davis
2016
University of Washington
2015
Anxiety, depression, and altered memory are associated with intestinal diseases, including inflammatory bowel disease (IBD). Understanding the link between these behavioral changes IBD is important clinically since concomitant mood disorders often increase a patient's risk of requiring surgery developing secondary functional gastrointestinal diseases. Anxiety-like behavior (light/dark box test) recognition (novel object task) were determined at peak during resolution inflammation in dextran...
Purpose Photophobia is a common and debilitating symptom associated with migraine. Women are disproportionately affected by migraines, higher prevalence more severe symptoms compared to men. This study investigated the effects of cortical spreading depression on light-aversive dark-seeking behaviors in rat model, an emphasis sex differences. Method Experiments were conducted seven eight-week-old male female Sprague Dawley rats. was modeled injections potassium chloride or artificial...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), enters host cells through two main pathways, both involving key interactions between viral envelope-anchored spike glycoprotein novel and receptor, angiotensin-converting enzyme (ACE2). To date, SARS-CoV-2 has infected up to 26 million people worldwide; yet, there is no clinically approved drug or vaccine available. Therefore, a rapid coordinated effort re-purpose drugs...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease 2019 (COVID-19), has resulted in an ongoing pandemic. Presently, there are no clinically approved drugs COVID-19. Hence, is urgent need to accelerate development of effective antivirals. Herein, we discovered Clioquinol (5-chloro-7-iodo-8-quinolinol (CLQ)), a Food and Drug Administration (FDA) drug, two its analogues (7-bromo-5-chloro-8-hydroxyquinoline (CLBQ14); 5,...
The purpose of this study was to identify potential metabolic pathways and metabolites OJT007, a methionine aminopeptidase 1 (MetAP1) inhibitor. OJT007 is novel drug with potent antiproliferative effects against Leishmania Major. We conducted in vitro Phase I oxidation II glucuronidation assays on using rat liver microsomes. Four unknown were initially identified UPLC-UV system from microsomal incubated samples. LC-MS/MS analysis then used the structural characteristics these via precursor...
ABSTRACT Objective Adolescents with psychiatric conditions may be at risk for xerostomia. In this preliminary study, we estimated xerostomia prevalence in adolescents ages 9 to 17 years from an inpatient clinic (N = 25) and examined whether: (1) gender age were associated (2) was self‐reported cavities. Methods We used a modified 11‐item Xerostomia Index identify (no/yes) asked if ever had or currently have cavities (no/yes). Results The mean 14 (SD 2.3) 72% male. Sixty percent reported 50)....
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease 2019 (COVID-19), has emerged as an ongoing global pandemic. Presently, there are no clinically approved vaccines nor drugs COVID-19. Hence, is urgent need to accelerate development of effective antivirals. Here in, we discovered Clioquinol (5-chloro-7-iodo-8-quinolinol (CLQ)), a FDA drug and two its analogues (7-bromo-5-chloro-8-hydroxyquinoline (CLBQ14); 5,...
The Online Blood Donation Management System, the purpose of which is to act as a bridge between person who needs blood, patient, and blood donor. design an automatic system has become integral part for saving human lives, need under different situations. Since, there are various drawbacks pre-existing like privacy issues donors, getting reflected directly on interface. Thus, we have designed robust that will create connection hospitals, NGOs, banks help patient in any difficult situation....
American trypanosomiasis, commonly referred to as Chagas disease, is caused by a single cell protozoan known Trypanosoma cruzi (T. cruzi). Although those affected are mainly in Latin America, has been detected the United States (US), Canada and many European countries due migration. Few studies have explored epidemiology of within US or changes disease burden over past decade. The objective this study was explore trends associated characteristics for among hospitalized women reproductive age...
The outbreak of SARS-CoV-2 infections around the world has prompted scientists to explore different approaches develop therapeutics against COVID-19. This study focused on investigating mechanism inhibition clioquinol (CLQ) and its derivatives (7-bromo-5-chloro-8-hydroxyquinoline (CLBQ), 5, 7-Dichloro-8-hydroxyquinoline (CLCQ)) viral glycoprotein, human angiotensin-converting enzyme-2 (hACE-2) involved in entry. drugs were docked at exopeptidase site hACE-2 receptor binding domain (RBD)...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent for coronavirus disease 2019 (COVID-19), and its ensuing mitigation measures have negatively affected Maternal Child Health (MCH) population. There is currently no surveillance system established to enhance our understanding of SARS-CoV-2 transmission guide policy decision making protect MCH population in this pandemic. Based on reports community household spread novel infection, we present an approach a robust...
Presently, there are six undergraduate HRSA-funded MCH pipeline training programs (MCHPTP) in the nation and they have gained significant momentum since inception by recruiting, mentoring students a comprehensive MCH-focused approach. This article describes outcomes from 6 programs; primarily Baylor College of Medicine-Texas Southern University (BCM-TSU's) collaborative strategy focusing on research outcomes, which align with HRSA's bureau's missions.Each MCHPTP offers trainees...
We assessed the impact of obesity and racial disparities on preterm birth (PTB) in United States sought to determine whether widens racial-ethnic disparity gap with a focus non-Hispanic Black White women.
<b>Abstract ID 22124</b> <b>Poster Board 356</b> The emergence of deadly SARS-CoV-2 variants with mutations on the viral genes has made it more imperative to discover therapeutics that target host receptors for COVID-19 treatment. Our research targeted critical entry receptor into human cells, Angiotensin-converting enzyme-2 (ACE2). Through a high-throughput screen we identified OJT009 as novel inhibitor SARS-CoV-2. Herein, our purpose is identify primary mechanism action against Interaction...
Despite recent advances in the diagnosis of Tuberculosis (TB), therapeutic management this ancient disease is still challenging. Mycobacterium tuberculosis , causative infectious agent TB, number one cause death from diseases world. According to World Health Organization TB report, globally, 558, 000 people developed multi‐drug resistance that was resistant most efficacious first‐line drug, rifampicin. The emergence and extensively drug strains M. has made requirement for development novel...
BACKGROUND: In forensic dentistry and medico-legal investigations the identication of skeletal remains is paramount importance. Mandible may play a vital role in sex determination, as it most dimorphic bone skull, which often recovered intact. Mandibular ramus gonial angle can be used to differentiate between sexes age estimation AIMS AND OBJECTIVES: The aim study was assess usefulness digital panoramic radiographs determine using linear measurements made with respect region population...
Cooperative as formal associations came to be set up in India from 1904 mainly credit societies, followed by non - societies 1912. Cooperatives are based on the cooperative values of “self help, self responsibility, democracy and equality, equity solidarity”. Modern dairy industry plays a vital role maintaining promoting health people. The cooperatives one largest most important food industries. Earlier, farming was basically domestic economic unit. It carried out at household level for...