A5020750644- melanin and skin pigmentation
- Immunotherapy and Immune Responses
- Tuberculosis Research and Epidemiology
- Skin Protection and Aging
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Peptides and Activities
- Hair Growth and Disorders
- Pharmaceutical studies and practices
- T-cell and B-cell Immunology
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Pharmacological Effects and Toxicity Studies
University of Alabama at Birmingham
2020-2024
Gray hair is a visible sign of tissue degeneration during aging. Graying attributed to dysfunction melanocyte stem cells (McSCs) that results in depletion their melanin-producing progeny. This non-lethal phenotype makes the follicle and its pigment system an attractive model for investigating mechanisms contribute aging therapeutic strategies combat this process. One potential combination RT1640, which comprised two drugs are known stimulate growth (cyclosporine A [CsA] minoxidil), along...
Summary A central aspect of life-long stem cell function in slow cycling cells is the proper regulation cellular quiescence. How quiescent state achieved, whether all are equivalent, and if pool changes with age questions that remain unanswered. Using melanocyte (qMcSC) as a model, we found quiescence neither singular nor static process can be heterogeneous. As one example this heterogeneity, show portion qMcSCs expresses immune checkpoint protein PD-L1 at membrane (PD-L1 mem+ ), better...
Abstract Neuropeptide Y (NPY) is a pleiotropic peptide produced in the central nervous system and peripheral organs. Despite conjectures that NPY may have role skin physiology pathology, effects of this organ remain poorly understood. We reported knock-in mouse with entopic overexpression exhibits significantly elevated skin, accompanied by premature progressive hair graying secondary to depletion melanocyte stem cells within follicles. However, question remains as whether can induce...