A5032370427- Science and Education Research
- Research on Leishmaniasis Studies
- Education during COVID-19 pandemic
- Educational Strategies and Epistemologies
- Sepsis Diagnosis and Treatment
- Innovative Teaching Methods
- Education and Critical Thinking Development
- Problem and Project Based Learning
- Science Education and Pedagogy
- Mobile Learning in Education
- Education and Digital Technologies
- Immune Response and Inflammation
- Toxin Mechanisms and Immunotoxins
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Education Pedagogy and Practices
- Animal and Plant Science Education
- Autoimmune and Inflammatory Disorders Research
- Eosinophilic Disorders and Syndromes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Trypanosoma species research and implications
Universidade Federal de Santa Catarina
2020-2022
Universidade Federal de Minas Gerais
2011-2021
Abstract Background and Purpose Neutrophil overstimulation plays a crucial role in tissue damage during severe infections. Because pathogen‐derived neuraminidase (NEU) stimulates neutrophils, we investigated whether host NEU can be targeted to regulate the neutrophil dysregulation observed Experimental Approach The effects of inhibitors on lipopolysaccharide (LPS)‐stimulated neutrophils from healthy donors or COVID‐19 patients were determined by evaluating shedding surface sialic acids, cell...
Objectives: To describe the implementation of a hybrid and an online active-learning-based science activity originally designed for face-to-face instruction. The goal was to verify if students used appropriate practices while engaged in problem solution through fully modalities. Epistemic are important markers scientific literacy because they reflect ways thinking working that similar those performed by scientists. Methods: Numerical experimental data related two topics immunology were...
We evaluated the role of IL-18 during Leishmania amazonensis infection in C57BL/6 mice, using IL-18KO mice. showed that is involved susceptibility to L. amazonensis, since mice presented reduced lesions and parasite loads. Because macrophages are host cells parasite, we investigated if were IL-18-mediated amazonensis. obtained from WT or responded similarly infection. Moreover, do not respond IL-18, they express IL-18R. Therefore,
Leishmania major -infected TNF receptor 1 deficient (TNFR1 KO) mice resolve parasitism but fail to lesions, while wild-type completely heal. We investigated the cell composition, cytokine production, and apoptosis in lesions from L. TNFR1 KO (WT) mice. Chronic presented larger number of CD8+ T Ly6G+ cells. In addition, higher concentrations mRNA for IFN- γ CCL2 CCL5, as well protein, lower numbers apoptotic cells, were found than WT, at late time points infection. Our studies showed that...
Abstract This article examines student engagement in an inquiry‐based learning activity, planned to provide students with elements the social, epistemic, and conceptual dimensions related scientific practice immunology. The activity was applied 39 groups of enrolled immunology or biochemistry courses a public university Brazil. Students performed data‐collection through execution vitro assay. We analyzed how represent data use them support their claims written constructs. To clarify which...
Neutrophil overstimulation plays a crucial role in tissue damage during severe infections. Neuraminidase (NEU)-mediated cleavage of surface sialic acid has been demonstrated to regulate leukocyte responses. Here, we report that antiviral NEU inhibitors constrain host activity, release, ROS production, and NETs released by microbial-activated human neutrophils. In vivo, treatment with Oseltamivir results infection control survival peritonitis pneumonia models sepsis. Single-cell RNA...
This study is a follow-up to the analysis of an inquiry-based learning activity applied students in public university Brazil. We advocate that effective education immunology must incorporate elements are essential research area, such as generating and analysing data. These would empower apply science reasoning face professional challenges. Our protocol included two these elements: experimentation abstraction. The utmost aim was examine production argument by groups engaged three different...
O ensino dos conteúdos da Imunologia, uma área das ciências biológicas que visa descrever e estabelecer os mecanismos de agressão, defesa integridade organismos vivos, está presente nos níveis educacionais, do básico ao superior currículos Biologia brasileira objetivo deste estudo foi caracterizar as pesquisas sobre metodologias desenvolvidas por pesquisadores em imunologia para aulas cursos apresentadas nas reuniões Sociedade Brasileira Imunologia (SBI) 2010 a 2017. Nossas análises...