A5040878416- T-cell and B-cell Immunology
- Aquaculture disease management and microbiota
- Genetic diversity and population structure
- Monoclonal and Polyclonal Antibodies Research
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Immune Cell Function and Interaction
- Genomics and Chromatin Dynamics
- Genetic Mapping and Diversity in Plants and Animals
- RNA and protein synthesis mechanisms
- Glycosylation and Glycoproteins Research
- Immune Response and Inflammation
- RNA Research and Splicing
- Animal Genetics and Reproduction
- interferon and immune responses
- Invertebrate Immune Response Mechanisms
- Animal Ecology and Behavior Studies
- Protein purification and stability
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Blood groups and transfusion
- Fish biology, ecology, and behavior
- Microbial infections and disease research
- Chemokine receptors and signaling
Laboratoire d'Annecy-le-Vieux de Physique Théorique
2022-2025
Université Savoie Mont Blanc
2022
Centre National de la Recherche Scientifique
2022
University of Tarapacá
2018
Max Planck Institute for Biology
1996-2015
University of Antofagasta
2013
TH Bingen University of Applied Sciences
2004
Max Planck Society
1987-2002
Princeton University
1999
Rhode Island Hospital
1995
Darwin’s finches comprise a group of passerine birds first collected by Charles Darwin during his visit to the Galápagos Archipelago. The group, textbook example adaptive radiation (the diversification founding population into an array species differentially adapted diverse environmental niches), encompasses 14 currently recognized species, which 13 live on Islands and one Cocos Island in Pacific Ocean. Although have been studied extensively morphologists, ecologists, ethologists, their...
Extant vertebrates are divided into three major groups: hagfishes (Hyperotreti, myxinoids), lampreys (Hyperoartia, petromyzontids), and jawed (Gnathostomata). The phylogenetic relationships among the groups within controversial, for both morphological molecular studies have rendered themselves to conflicting interpretations. Here, we use sequences of 35 nuclear protein-encoding genes provide definitive evidence monophyly Agnatha (jawless vertebrates, a group encompassing lampreys). Our...
The origin of tetrapods is a major outstanding issue in vertebrate phylogeny. Each the three possible principal hypotheses (coelacanth, lungfish, or neither being sister group tetrapods) has found support different sets data. In an attempt to resolve controversy, sequences 44 nuclear genes encoding amino acid residues at 10,404 positions were obtained and analyzed. However, this large set did not conclusively one hypotheses. Apparently, coelacanth, tetrapod lineages diverged within such...
Two features make the tooth an excellent model in study of evolutionary innovations: relative simplicity its structure and fact that major tooth-forming genes have been identified eutherian mammals. To understand nature innovation at molecular level, it is necessary to identify homologs other vertebrates. As a first step toward this goal, amelogenin gene cloned characterized selected species monotremes (platypus echidna), reptiles (caiman), amphibians (African clawed toad). Comparisons...
Summary Thirty-two t haplotypes were extracted from wild mice captured in Central Europe, Spain, the Soviet Union, Israel, Egypt, Orkneys and South North America, tested for lethality homozygous state. Twenty-two proved to be lethals, 8 semilethals 2 viables. The lethal then by genetic complementation test identity with representatives of known groups each other. Five 22 carry previously identified factors ( w5 , w73 Lub-1 ), while rest carried new factors. 17 fell into groups. Two are...
Twenty cDNA clones derived from beta-chain-encoding class II genes of the zebrafish (Brachydanio rerio) major histocompatibility complex (MHC) have been sequenced. They fall into three groups identifying loci expressed genes. The length and organization these are similar to those their mammalian homologs. Amplification by polymerase chain reaction sequencing genomic DNA collected at different locations in India indicate existence a fourth group sequences (fourth locus). A high degree...
Abstract The species flocks of cichlid fishes in the Great East African Lakes are paradigms adaptive radiation and hence, great interest to evolutionary biologists. Phylogenetic studies these have, however, been hampered by lack suitable polymorphic markers. genes major histocompatibility complex hold promise provide, through their extensive polymorphism, a large number such markers, but use has complexity genetic system definition individual loci. In this study we take first substantial...
Using three genomic phage libraries, we isolated 26 clones from the zebrafish MHC class II B region. By restriction mapping, could be arranged into six clusters, most clusters consisting of several overlapping clones. The combined cover a total 161 kb Hybridization with specific probes demonstrated presence in two A and genes. Sequencing genes revealed that they represented different families loci. Only one are complete; others truncated pseudogenes. loci shows extensive fragment length...
The genomic organisation of the Major Histocompatibility Complex (MHC) varies greatly between different vertebrates. In mammals, classical MHC consists a large number linked genes (e.g. greater than 200 in humans) with predominantly immune function. some birds, it only small core smaller 20 chickens) forming minimal essential and, fish, so far unknown including non-linked genes. Here we report survey and their paralogues zebrafish genome.Using sequence similarity searches against draft...
The LMP2 and LMP7 genes code for subunits of the proteasome, a multimeric enzymatic complex that degrades proteins into peptides. two replace corresponding constitutively expressed during immune response. Some peptides generated by proteasome in cytosol are transported products TAP1 TAP2 lumen endoplasmic reticulum loaded onto assembling MHC class I molecules. In mammals, LMP2, LMP7, TAP1, reside II region Mhc, closely linked to RING3 gene. present study we identified, cloned, sequenced LMP,...