Background Lifelong pulmonary consequences of being born extremely preterm or with low birth weight remain unknown. We aimed to describe lung function trajectories from 10 35 years age for individuals preterm, and address potential cohort effects over a period that encompassed major changes in perinatal care. Methods performed repeated spirometry three population-based cohorts at gestational ≤28 weeks ≤1000 g during 1982–85, 1991–92 1999–2000, referred as preterm-born, term-born controls...

The association between bronchiolitis in the first year of life and subsequent asthma, atopy, airway obstruction bronchial hyper-responsiveness (BHR) is unsettled. Genetic predispositions, pre-morbid lung function, environmental interactions altered immunological responses are risk factors that have been studied. aim this study was to assess BHR occurrence asthma atopy 11 yr after hospitalization for life, particularly focusing on role gender virus involved. included 121 131 (92%) children...

Hospitalisation for bronchiolitis is a risk factor asthma and impaired lung function during childhood, but outcomes in young adults are poorly described. Our primary aim was to study the prevalence of atopy, at 17-20 years age after infancy and, secondarily, impact viral aetiology (respiratory syncytial virus (RSV) vs non-RSV) sex on these outcomes.This Norwegian cohort enrolled 225 hospitalised 1996-2001 167 matched control subjects. The follow-up included questionnaires examinations atopy....

Abstract Bronchiolitis in infancy is a risk factor for development of asthma the first decades life, although majority may be asymptomatic at school age. Respiratory symptoms are common early and prediction later challenging. We aimed to study if simple clinical variables assessed 2 years age could predict 11 thereby provide basis follow‐up treatment after bronchiolitis infancy. The included 105 children hospitalized during their year life. Of these, 101 (96.2%) participated 93 (88.6%)...

An association between body weight in childhood and subsequent lung function asthma has been suggested, but few longitudinal studies exist. Our aim was to explore whether weight-related anthropometric measurements through were associated with late childhood. From an original nested case-control study, a cohort study conducted, where measured 463 children aged 12.8 years, anthropometry at several ages from birth years of age. Associations anthropometrics analysed using multiple linear...

To study if blood eosinophils during bronchiolitis were associated with atopy, asthma and lung function in young adults these associations differed between respiratory syncytial virus (RSV) non-RSV bronchiolitis.This historical cohort enrolled 225 subjects. Blood measured infancy, the subjects invited to a follow-up at 17-20 years of age including questionnaires for examinations atopy.The level was positively subsequent atopy unadjusted analysis, but not adjusted asthma. There negative...

Abstract Aim To (1) compare the perceived benefit of long‐term mechanical insufflation‐exsufflation (MI‐E) children with neuromuscular disorders (NMDs) and central nervous system (CNS) disorders, including health care needs treatment routines (2) describe children's health‐related quality life (HRQoL). Method This cross‐sectional study used a questionnaire memory card data to assess MI‐E via Visual Analogue Scale (VAS; 10 maximum), willingness pause treatment, level before after initiation,...

Introduction: Variable airflow obstruction that can be confirmed by diurnal variability of peak expiratory flow (PEF) >13% is an important characteristic asthma. Home monitoring PEF may helpful to diagnose and monitor In this feasibility study, we aimed study if asthmatic children measure at home twice daily during a 4-week period using device designed as "whistle" smart phone software application. Materials Methods: Twice 4 weeks, aged 5–12 years with current asthma rated their condition...

Background Mechanical insufflation–exsufflation (MI-E) is used to augment cough in children with neurodisability. We aimed determine the user comfort and flows during three MI-E strategies, predict factors associated improved flows. Methods This multicentre, crossover trial was done at four regional hospitals Norway. Children neurodisability using long term via mask were enrolled. In randomised order, they tested setting strategies (in-/exsufflation pressure (cmH 2 O)/in (In)- versus...

The prevalence of childhood asthma has increased, although the rate hospitalization for seems to decrease. In Norway, hospital admission from 1984 2000 increased. aim this study was assess further trends in admissions up 2010.A population-based including children 1-13 yrs age hospitalized during six periods 1984/1985 2009/2010 Rogaland, performed. Medical records 1536 (1050 children) were studied; and gender, age, number admissions, length stay, medications symptoms recorded.For all groups,...

Abstract Background Although guidelines for treatment of wheeze and asthma in preschool children are available, symptoms overlapping it may be difficult to decide which should given inhaled corticosteroids ( ICS ). Previous studies suggest an inappropriate prescription pattern this age group. We studied time trends use Norway during 2004–2013 by age, gender physician specialty, the persistence years. Methods Data were drawn from Norwegian Prescription Database. The study population consisted...

Abstract Background Various trajectories for lung function and bronchial hyper‐reactivity (BHR) from early childhood to adulthood are described, including puberty as a period with excessive growth. Bronchiolitis in infancy may be associated increased risk of developing chronic obstructive pulmonary disease, but the development respiratory patterns during is poorly characterized these children. We aimed study BHR 11 18 years age children hospitalized bronchiolitis infancy. Methods Infants at...

Aim To determine the prevalence of long‐term mechanical insufflation‐exsufflation (MI‐E) and concomitant ventilation in children with neurological conditions, reported reasons behind initiation treatment. Method This was a population‐based, cross‐sectional study using Norwegian national registries questionnaire. Results In total, 114 19 264 condition had an MI‐E device. Seventy‐three 103 eligible (31 females, 42 males), median (min–max) age 10 years 1 month (1y 5mo–17y 10mo), their treatment...

The fraction of exhaled nitric oxide (FeNO) has been suggested as a non-invasive marker eosinophilic inflammation in asthma, but lately rather biomarker atopy than asthma itself. Asthma after bronchiolitis is common up to early adolescence, the and pathophysiology may differ from other phenotypes childhood asthma. We aimed assess if FeNO was different children with former hospitalization for control group, explore whether role or bronchial hyperresponsiveness (BHR) differed between these two...

Abstract Diagnosing asthma and deciding treatment are difficult in young children. An inappropriate too high prescription rate of inhaled corticosteroids (ICS) is suggested, but how airway symptoms associated with prescriptions medication less known. We studied strongly wheeze, lower respiratory tract infections (LRTI), atopic diseases dispensing medications during early childhood. used data from the Norwegian Mother Child Cohort Study Prescription Database at four age‐intervals (0‐6, 6‐18,...

Abstract Aim To assess whether inflammatory markers measured in urine and blood during acute bronchiolitis infancy were associated with asthma, lung function, bronchial hyper‐responsiveness ( BHR ) atopy at 11 years of age. Methods We included 105 children hospitalised for their first year life. At hospitalisation, urinary U ‐) eosinophil protein X , ‐leukotriene E 4 U‐prostaglandin 9α, 11β‐ PGF 2 counts measured. Ninety‐five (90%) available follow‐up Results follow‐up, higher obtained...

Astma kan være vanskelig å diagnostisere hos barn. For barn under skolealder finnes det få tilgjengelige objektive diagnostiske undersøkelser, og retningslinjene for diagnose behandling er basert på sykehistorie klinisk undersøkelse. Dette gi rom varierende behandlingspraksis.Data fra Reseptregisteret ble brukt til studere forskrivning av legemidler mot astma i aldersgruppene 0-4 år 5-9 fordelt fylker 2004-15.Det var stor variasjon mellom fylkene andelen per 1 000 som fikk forskrevet...

Abstract Aim We aimed to study the natural course of recurrent episodic and chronic wet cough in preschool children, proportion age resolution, risk factors for persistent symptoms. Methods Parents children with or who had attended outpatient clinic before three years during 2010‐2013 at Stavanger University Hospital, Norway, answered a questionnaire regarding clinical symptoms current medication follow‐up 2017‐2018. Results invited 840 participate, parents consented 348 (41.4%) children. At...

Abstract Aim Advances in perinatal medicine from 1980 to 2000 improved survival extremely preterm (EP) neonates. Long‐term effects of these developments remain unclear, and we aimed investigate potential cohort on adult lung function. Methods Three 18‐year‐old population‐based cohorts born at ≤28 weeks gestation or with birthweight ≤1000 g during 1982–85, 1991–92 1999–2000 term‐controls underwent spirometry, body plethysmography, tests diffusing capacity, bronchodilator reversibility, airway...