A5002753227- Fungal Biology and Applications
- Phytochemistry and Bioactivity Studies
- Bee Products Chemical Analysis
- Silymarin and Mushroom Poisoning
- Phytochemicals and Antioxidant Activities
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Microbial Natural Products and Biosynthesis
- Medicinal plant effects and applications
- Antioxidant Activity and Oxidative Stress
- Edible Oils Quality and Analysis
- Cholinesterase and Neurodegenerative Diseases
- Pomegranate: compositions and health benefits
Ankara University
2016-2025
Queen's University Belfast
2024
Pfizer (United Kingdom)
2021
Kyiv City Clinical Oncology Center
2019
Ministry of Food Agriculture and Livestock
2018
Abstract Chronic infected diabetic wounds are complex and often lead to severe clinical outcomes such as sepsis, gangrene, amputation. To address these challenges, herein we developed a novel tri‐layered scaffold provide multi‐functional therapeutic support. The bottom poly (lactic‐co‐glycolic acid) (PLGA) fibrous layer contains doxycycline loaded CuBDC nanosheets for rapid antibacterial action. porous PLGA/gelatin middle offers mechanical support γ‐tocotrienol ZIF‐8 nanocrystals mitigates...
This study is based on the phenolic composition and antioxidant, anticancer, antimicrobial, antibiofilm activities of edible mushroom Marasmius oreades from Turkey. The an M. ethanol extract was measured by using Folin-Ciocalteu method, aluminium chloride colorimetry, ultraperformance liquid chromatography. antioxidant activity evaluated basis DPPH radical scavenging activity. effect also screened in order to determine glutathione-S-transferase, glutathione peroxidase, catalase, superoxide...
Ribosome quality control (RQC) resolves collided ribosomes, thus preventing their cytotoxic effects. The chemotherapeutic agent 5-Fluorouracil (5FU) is best known for its misincorporation into DNA and inhibition of thymidylate synthase. However, while a major determinant 5FU's anticancer activity RNAs, the mechanisms by which cancer cells overcome RNA-dependent 5FU toxicity remain ill-defined. Here, we report role RQC in mitigating effects 5FU. We show that treatment results rapid induction...
Ethanolic extracts of the mushroom species Ganoderma adspersum, Inonotus hispidus, Russula chloroides, and Sarcodon imbricatus were investigated for their polyphenolic contents biological activities.The radical scavenging activity was evaluated by 2,2-diphenyl-1-(2,4,6-trinitrophenyl) (DPPH) method compounds determined high performance liquid chromatography (HPLC) analysis. Furthermore, effects on enzyme glutathione-S-transferase (GST) also examined. Additionally, antimicrobial disc...
The antioxidant capacity of Fomitopsis pinicola extracts was determined based on DPPH radical scavenging activites. Their total phenolic and flavonoid contents were also investigated. Antioxidant enzymes are important in controlling oxidative stress maintaining cellular homeostatis. They can protect cells from the deleterious effects reactive oxygen species prevent development degenerative diseases such as Alzhemier disease, Parkinson cancer, even aging. In this regard, modulatory activities...
This study examines the antioxidant, anticancer, antimicrobial, and antibiofilm activities of Hydnum repandum, an edible medicinal mushroom known as sweet tooth or wood hedgehog. H. repandum ethanolic extract had a high amount myricetin apigenin displayed antiproliferative effects against MCF-7 HT-29 cell lines. Moreover, antimicrobial methicillin-resistant Staphylococcus aureus ATCC 43300, S. epidermidis 35984, Escherichia coli 25922, Pseudomonas aeruginosa 27853. Synergetic interactions...
Extra virgin olive oil is the highest grade of derived by cold mechanical extraction without use solvents or refining methods. These oils are known for their composition in phenolic compounds that have antioxidant properties. This study aims to determine total and flavonoid activities four Turkish extra samples: Kilis yağlık, İzmir sofralık, Ayvalık, Tavşan yüreği. The sample concentration used experiments was 4 mg/ml while 1 mg/mL ABTS radical scavenging assay. lowest content observed...
Clitocybe mushrooms have long been recognized for their various therapeutic potential and medicinal properties. A few members of the genus are considered edible many others poisonous. This study investigated ethanolic extracts obtained from C. nebularis (CN) I. geotropa (IG) phenolic content antioxidant, antiproliferative, antimicrobial, antibiofilm activities. The data ultra-performance liquid chromatography Fourier transform infrared spectroscopy analysis were presented first time....
Objectives: Ethanolic extracts of Ganoderma adsperum, Inonotus hispidus, Russula chloroides and Sarcodon imbricatus mushroom species were investigated for their polyphenolic contents biological activities. Materials Methods:The radical scavenging activity the evaluated by using DPPH 2,2-Diphenyl-1-(2,4,6-trinitrophenyl) method compounds determined HPLC analysis.Furthermore, effects on GST (glutathione-S-transferase) enzyme also examined.Additionally, antimicrobial with disc diffusion method....