A5044240597- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Resistance in Bacteria
- Microbial Community Ecology and Physiology
- Bacteriophages and microbial interactions
- Wastewater Treatment and Nitrogen Removal
- Coastal wetland ecosystem dynamics
- Parathyroid Disorders and Treatments
- Arsenic contamination and mitigation
- Aquaculture disease management and microbiota
- Genomics and Phylogenetic Studies
- Environmental DNA in Biodiversity Studies
- Vibrio bacteria research studies
- Helminth infection and control
- Advanced Text Analysis Techniques
- Information Retrieval and Search Behavior
- Ethics in Clinical Research
- Cystic Fibrosis Research Advances
- Chromium effects and bioremediation
- Pesticide Residue Analysis and Safety
- Plant Stress Responses and Tolerance
- Microbial infections and disease research
- Bacterial biofilms and quorum sensing
- Insect symbiosis and bacterial influences
- Text and Document Classification Technologies
- Water Treatment and Disinfection
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2022-2025
Sun Yat-sen University
2022-2025
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2023-2024
South China Agricultural University
2016-2020
Key Laboratory of Guangdong Province
2020
Seasonal variations of environmental factors generally result in considerable changes microbiomes, yet we still lack a clear understanding how microbial communities maintain their ecological stability. Here, analyze long-term (nine years) high-throughput sequencing dataset by network analysis to illustrate the stability varies among seasons lake ecosystems. The results showed that networks were distinctly different seasons, and most complex autumn exhibited highest We found strong connecting...
Abstract Background Phosphorus (P) is one of the most essential macronutrients on planet, and microorganisms (including bacteria archaea) play a key role in P cycling all living things ecosystems. However, our comprehensive understanding genes (PCGs) (PCMs) as well their ecological functions remains elusive even with rapid advancement metagenome sequencing technologies. One major challenges lack accurately annotated functional gene database. Results In this study, we constructed well-curated...
Antibiotic resistance genes (ARGs) in the environment are promoted by anthropogenic activities, which cause potential risks to human health. However, large-scale quantitative data on antibiotic resistome from pristine and environments remains largely unexplored. Here, we used metagenome-wide analysis investigate share divergence ARG profiles their bacterial hosts between gut-associated environments. We found that abundance of total ARGs was significantly higher than (P < 0.001). The mcr-1...
Widespread use of antibiotics has enhanced the evolution highly resilient pathogens and poses a severe risk to human health via coselection antibiotic resistance genes (ARGs) virulence factors (VFs). In this study, we rigorously evaluate abundance relationship physical linkage between ARGs VFs by performing comprehensive analysis 9,070 bacterial genomes isolated from multiple species hosts. The coexistence was observed in bacteria across distinct phyla, pathogenicities, habitats, especially...
Microorganisms play crucial roles in phosphorus (P) turnover and P bioavailability increases heavy metal-contaminated soils. However, microbially driven P-cycling processes mechanisms of their resistance to metal contaminants remain poorly understood. Here, we examined the possible survival strategies microorganisms horizontal vertical soil samples from world's largest antimony (Sb) mining site, which is located Xikuangshan, China. We found that total Sb pH were primary factors affecting...
In 2018, China implemented the Veterinary Antimicrobial Use Reduction Action to curb rapid development of antibiotic resistance (AR). However, AR-related pollutions in animal farms after reduction policy has been poorly investigated. Here, we performed a comprehensive investigation combining UPLC-MS/MS, metagenomic, and bacterial genomic analyses eight representative large-scale chicken Guangdong, China. Our results showed that antibiotics ARGs contaminations were more severe broiler than...
In this study, we examined the types of antibiotic resistance genes (ARGs) possessed by bacteria and bacteriophages in swine feedlot wastewater before after treatment using a metagenomics approach. We found that relative abundance ARGs bacterial DNA all water samples was significantly higher than phages (>10.6-fold), did not change bacterial- or phage-associated ARGs. further detected distribution diversity different according to class antibiotics which they confer resistance, tetracycline...
The recruitment of microorganisms by plants can enhance their adaptability to environmental stressors, but how root-associated niches recruit specific for adapting metalloid-metal contamination is not well-understood. This study investigated the generational in different root
Increasing nitrogen (N) input to coastal ecosystems poses a serious environmental threat. It is important understand the responses and feedback of N removal microbial communities, particularly nitrifiers including newly recognized complete ammonia-oxidizers (comammox), improve aquaculture sustainability. In this study, we conducted holistic evaluation functional communities responsible for nitrification by quantifying sequencing key genes comammox Nitrospira-amoA, AOA-amoA, AOB-amoA...
Mangrove ecosystems are globally recognized for their blue carbon (C) sequestration capacity. Lignocellulosic detritus constitutes the primary C input to mangrove sediments, but microbial processes involved in its bioprocessing remain unclear. Using lignocellulosic analysis and metagenomic sequencing across five 100-cm sediment cores, we found a high proportion of lignin (95.0–97.7%) within sediments' detritus, with small fraction lignin-degrading genes (1.24–1.98%) carbohydrate-active...
The emergence of plasmid-mediated tet(X3)/tet(X4) genes is threatening the role tigecycline as a last-resort antibiotic to treat clinical infections caused by XDR bacteria. Considering possible public health threat posed tet(X) and its variants [which we collectively call 'tet(X) genes' in this study], global monitoring surveillance are urgently required.Here conducted worldwide survey distribution spread genes.We analysed comprehensive dataset bacterial genomes conjunction with data from...
Duck farms are one of the important reservoirs antimicrobial resistance genes (ARGs) that spread to humans and environment. However, few studies have focused on characteristics profiles in duck farms. Here we explored distribution potential transmission mechanisms ARGs ducks, farm workers, environment by a metagenomic approach. The results showed highest abundance diversity were found manure. workers environmental samples higher than those control group. tet(X) its variants prevalent farms,...
Drinking water systems host a wide range of microorganisms essential for biosafety. However, one major group waterborne pathogens, protozoa, is relatively neglected compared to bacteria and other microorganisms. Until now, little known about the growth fate protozoa their associated in drinking systems. In this study, we aim investigate how treatment affects subtropical megacity. The results showed that viable were prevalent city's tap water, amoebae component protozoa. addition,...
Mutant prevention concentration (MPC) is an alternative pharmacodynamic parameter that has been used to measure antimicrobial activity and represents the propensities of agents select resistant mutants. The range between minimum inhibitory (MIC) MPC defined as mutant selection window (MSW). MSW parameters represent ability inhibit bacterial mutants selected. This study was conducted determine MIC values four antimicrobials including ceftiofur, cefquinome, florfenicol tilmicosin against 105...
Abstract Mangrove sediments host a diverse array of microbial populations and are characterized by high heterogeneity along their vertical depths. However, the genetic diversity within these is largely unknown, hindering our understanding adaptive evolution across sediment To elucidate diversity, we utilized metagenome sequencing to identify 16 high‐frequency comprised two archaea 14 bacteria from mangrove cores (0–100 cm, with 10 depths) in Qi'ao Island, China. Our analysis genome‐wide...
Antibiotic resistance poses a significant threat to human health. While most studies focus on bacteria, interactions between antibiotics and other crucial microbial groups like protists remain uncertain. This study investigates how interact with examines these impact the fate of genes. It reveals that amoebae exhibit high eight high-risk environmental antibiotics, accumulating quantities within their cells. Wild amoeboid strains from distant locations carry substantial antibiotic genes...