A5015758751- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Amoebic Infections and Treatments
- Parasitic Infections and Diagnostics
- Calcium signaling and nucleotide metabolism
- Innovation and Socioeconomic Development
- Biliary and Gastrointestinal Fistulas
- Neurological Disorders and Treatments
- HIV Research and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Forest Management and Policy
- Vibrio bacteria research studies
- RNA modifications and cancer
- Forest Biomass Utilization and Management
- Antibiotic Resistance in Bacteria
- CRISPR and Genetic Engineering
- Advanced Glycation End Products research
- Pediatric Hepatobiliary Diseases and Treatments
- Diagnosis and treatment of tuberculosis
- Bioenergy crop production and management
- MicroRNA in disease regulation
- Escherichia coli research studies
- Pancreatitis Pathology and Treatment
- Lysosomal Storage Disorders Research
- Phagocytosis and Immune Regulation
New York University
2012-2018
Institute of Genomics and Integrative Biology
2015
International Centre for Genetic Engineering and Biotechnology
2012
Indira Gandhi Agricultural University
2010
Jawaharlal Nehru University
2003-2006
Mycobacterium tuberculosis (Mtb) disrupts anti-microbial pathways of macrophages, cells that normally kill bacteria. Over 40 years ago, D'Arcy Hart showed Mtb avoids delivery to lysosomes, but the molecular mechanisms allow elude lysosomal degradation are poorly understood. Specialized secretion systems often used by bacterial pathogens translocate effectors target host, and encodes type VII (TSSSs) enable mycobacteria secrete proteins across their complex cell envelope; however, cellular...
Mycobacterium tuberculosis causes tuberculosis, which kills more people than any other infection. M. grows in macrophages, cells that specialize engulfing and degrading microorganisms. Like many intracellular pathogens, order to cause disease, damages the membrane-bound compartment (phagosome) it is enclosed after macrophage uptake. Recent work showed when chemicals damage this type of compartment, rapidly detect repair damage, using machinery called endosomal sorting complex required for...
ABSTRACT The type VII secretion systems are conserved across mycobacterial species and in many Gram-positive bacteria. While the well-characterized Esx-1 pathway is required for virulence of pathogenic mycobacteria conjugation model organism Mycobacterium smegmatis , Esx-3 contributes to mycobactin-mediated iron acquisition these Here we show that several components individually function under low-iron conditions but at least one, membrane-bound protease MycP 3 M. partially expendable. All...
Abstract Background Diabetic neuropathy and idiopathic are among the most prevalent neuropathies in human patients. The molecular mechanism underlying pathological changes observed affected nerve remains unclear but one candidate molecule, receptor for advanced glycation end‐products ( RAGE ), has recently gained attention as a potential contributor to neuropathy. Our previous studies revealed that expression is higher porcine murine diabetic nerve, contributing inflammatory mechanisms...
The signaling proteome of Entamoeba histolytica is made transmembrane kinases (TMKs) that are rarely found in unicellular eukaryotes. There 90 TMK genes reported for E. histolytica, and these have been grouped into nine distinct families based on motifs present both extracellular kinase domains. Of these, the B1 family was chosen further analysis. Genomic sequencing revealed presence 28 members belonging to this family. Genes corresponding majority were truncated not considered Only five...
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis. Analysis proteins secreted by Mtb has been interest to field research since certain interact with host promote virulence, while others may be important antigens or serve as biomarkers infection. Here, we describe a protocol prepare whole cell extracts (WCE) and short term culture filtrate (CF) from vaccine strain bovis- bacillus Calmatte- Guérin (BCG) (Mehra et al., 2013). These are both slow growing mycobacteria, but...
Phagolysosomal trafficking is an important innate defense pathway that clears microbes by delivering them to lysosomes, the degradative compartment of cell. Mycobacterium tuberculosis (Mtb), causative agent tuberculosis, subverts this host mechanism arresting maturation phagosome. The ability Mtb arrest its delivery lysosome can be demonstrated prolonged co-localization bacteria containing phagosomes/vacuole with early phagosomal markers [such as, Ras-related proteins in brain 5 (Rab5) and...
In an attempt to understand the role of genes with no known function, in protozoan parasite Entamoeba histolytica, analysis proteome was carried out and a Lysine-Rich protein (KRP) identified for further study. This has modular structure four domains found be expressed localized cell surface E. histolytica trophozoites. The KRP over expressing cells were 80% less virulent as compared under gene determined by ability kill vitro target cells. results suggest that may have cytopathogenesis parasite.