AimsComplications after cardiac implantable electronic device (CIED) treatment, including permanent pacemakers (PMs), resynchronization therapy devices with defibrillators (CRT-Ds) or without (CRT-Ps), and cardioverter (ICDs), are associated increased patient morbidity, healthcare costs, possibly mortality.

OBJECTIVE--Correlation of the urinary albumin excretion rate and risk death among elderly subjects. DESIGN--216 Subjects aged 60-74 whose had been determined were followed up 62-83 months later. SETTING--Municipality Fredericia, Denmark. SUBJECTS--223 People who selected as control subjects for diabetics found during a systematic screening diabetes all people living in municipality Of these subjects, 216 an extensive clinical biochemical examination within few weeks selection. MAIN OUTCOME...

Background: Three randomised trials have demonstrated reduction in mortality from colorectal cancer (CRC) by repeated screening with faecal occult blood tests, including the trial presented here, which is only one still progress. Aims: To evaluate after seven rounds and possible influence of compliance on CRC. Methods: At Funen Denmark, random allocation to biennial Hemoccult-II 30 967 subjects aged 45–75 years 966 controls was performed 1985 a population 137 485 same age. Only participants...

Infection is a serious complication of pacemaker (PM) systems. Although the rate infection has been debated, figures are largely unknown. We therefore studied incidence PM and its associated risk factors in Danish population. Since 1982, all implantation removal procedures performed Denmark have prospectively recorded Pacemaker Register. All patients (n = 46299) who underwent between 1982 2007 were included. The total length surveillance was 236 888 PM-years. calculated according to number...

Abstract Aims Device-related infection (DRI) is a severe complication to cardiac implantable electronic devices (CIED) therapy. incidence and its risk factors differ between previous studies. We aimed define the long-term rates of DRI for different types CIEDs in complete Danish device-cohort identify patient-, operation- device-related DRI. Methods results From Pacemaker (PM) cardioverter-defibrillator (ICD) Register, we included consecutive patients undergoing CIED implantation or...

The possible benefit for patients from follow-up examinations after curative surgery colorectal cancer is unproven. purpose of this study was to determine whether survival improved by frequent examinations. A total 597 less than 76 years old treated with radical were included in the 1983 1994. Patients randomized followup (group 1) or virtually no 2) at 5 and 10 years. Group 1 comprised 290 patients, group 2 contained 307. Recurrence equally (26 per cent), but time diagnosis 9 months earlier...

Background: Two large true population studies in Europe have shown a significant reduction mortality from colorectal cancer (CRC) by screening with faecal occult blood test. In one trial conducted Funen County, 61,933 individuals (aged 45–75 years) were randomly allocated either to control group or receive biennial Hemoccult‐II Methods: These followed 1985 2002 and 9 rounds performed. Results: First was accepted 67% (20,672). Positivity rates varied between 0.8% 3.8%, the cumulative...

The results of a prospective randomized study 1056 patients with colorectal adenomas are presented. After initial polypectomy from 1978 to 1992, were allocated at random different follow-up intervals varying 6 48 months, except 53 who months. examinations mainly done by colonoscopy. Ten developed carcinoma, number similar that expected (7.96), when compared sex- and age-matched normal Danish population. carcinomas was also calculated adenoma carcinoma conversion rates estimated in other...

Gene duplication with subsequent interaction divergence is one of the primary driving forces in evolution genetic systems. Yet little known about precise mechanisms and role protein networks from prokaryote eukaryote domains. We developed a novel, model-based approach for Bayesian inference on biological network data that centres approximate computation, or likelihood-free inference. Instead computing intractable likelihood topology, our method summarizes key features and, based these, uses...

Flexible sigmoidoscopy (FS) has been recommended as a screening method to reduce mortality from colorectal cancer (CRC). The present study evaluates the effect of adding FS fecal occult blood test Hemoccult-II (H-II) on diagnostic yield neoplasia.A total 10,978 normal persons aged 50-75 years were invited participate, 5495 being allocated at random H-II and 5483 alone.In spite lower compliance (40% versus 56%) for combined procedure, neoplasia was higher than alone (12 CRC 4 CRC, 72 large...

To evaluate the incidences of and risk factors predisposing to appropriate inappropriate shocks mortality in a 'real-world' population patients with ischaemic heart disease (IHD) implantable cardioverter defibrillators (ICD) for primary prevention sudden cardiac death (SCD). In this nationwide cohort, we prospectively followed 1609 IHD left ventricular dysfunction from Danish ICD Register who received an SCD (1 January 2007 30 November 2011). Primary study outcomes were shocks, all-cause...

Abstract Aims Cardiac implantable electronic device (CIED) infection is a severe complication to modern management of cardiac arrhythmias. The CIED type and the surgery are recognized as risk factors for infections, but knowledge patient-related scarce. This study aimed identify lifelong infections. Methods results Consecutive Danish patients undergoing implantation or reoperation between January 1996 April 2018 were included. cohort consisted 84 429 108 494 surgeries with combined follow-up...

Abstract OBJECTIVES: Minimally invasive video-assisted thoracic surgery (VATS) was first introduced in the early 1990s. For decades, numerous non-randomized studies demonstrated advantages of VATS over thoracotomy with lower morbidity and shorter hospital stay, but only recently did a randomized trial document that results pain scores better quality life. Opposing arguments for have always been increased costs concerns about oncological adequacy. In this paper, we aim to investigate...

Background: We wanted to assess the influence of various surveillance intervals on risk new neoplasia after removal pedunculated and small sessile tubular tubulovillous adenomas.Methods: After initial colonoscopic polypectomy patients were randomized with either 2 years (group A) or 4 B) between colorectal examinations.Results: The cumulated a patient having adenomas was 35.0% (28.7-41.4%) in group A 35.5% (28.4-42.7%) B 48 months. increased 44.9% (36.0-53.9%) 60.1% (48.5-71.7%),...

Objective: To evaluate the diagnostic yield, learning curve and safety of endobronchial ultrasound-guided transbronchial needle biopsy (EBUS-TBNA) in mediastinal staging patients with lung cancer.Methods: Mediastinal was performed EBUS-TBNA according to Danish national guidelines fulfilling one or more following criteria: (1) central tumour; (2) enlarged (>10 mm) lymph nodes on computed tomography; (3) positron emission tomography (PET)-positive nodes.The study period began January 2006 when...

To examine the cumulative incidence of and covariates' association with new onset anxiety depression in implantable cardioverter defibrillator (ICD) patients during 24 months follow-up without at implant. Patients (n = 1040; 155 (14.9%) women; mean age: 64.2 ± 10.6) a first-time ICD enrolled national, multi-center prospective observational DEFIB-WOMEN study comprised cohort. We obtained information on demographic clinical data from Danish Pacemaker Register. During follow-up, 138 (14.5%)...

Between 1978 and 1992 a total of 1689 colorectal adenomas were removed in 1042 patients with no history previous neoplasms. One hundred eighteen had at least one adenoma severe dysplasia. A 'clean colon' was ensured by colonoscopy 97% the patients. multiple logistic model used to assess independent risk factors associated The size largest extent villous component identified as patient high results indicated that dysplasia is large and/or even higher when are found sigmoid colon or rectum.