John Campos
A5071368255- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Gene expression and cancer classification
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Molecular Biology Techniques and Applications
- Medical Malpractice and Liability Issues
- Airway Management and Intubation Techniques
- Cancer Genomics and Diagnostics
- Traumatic Brain Injury Research
- RNA modifications and cancer
- Immunotoxicology and immune responses
- Congenital Heart Disease Studies
- Functional Brain Connectivity Studies
- Cell Image Analysis Techniques
- Autopsy Techniques and Outcomes
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Patient Safety and Medication Errors
- Cancer, Hypoxia, and Metabolism
- Quality and Safety in Healthcare
- Bioinformatics and Genomic Networks
University of Washington
2007-2024
Faculdade de Medicina do ABC
2024
Universidade José do Rosário Vellano
2024
Health Outcomes Solutions (United States)
2015
Windber Research Institute
2013-2015
Walter Reed National Military Medical Center
2013
University of North Carolina at Chapel Hill
2013
Virginia Mason Medical Center
2010
The initial findings from the Pediatric Perioperative Cardiac Arrest (POCA) Registry (1994-1997) revealed that medication-related causes, often cardiovascular depression halothane, were most common. Changes in pediatric anesthesia practice may have altered causes of cardiac arrest anesthetized children.Nearly 80 North American institutions provide for children voluntarily enrolled Registry. A standardized data form each perioperative </=18 yr age was submitted anonymously. We analyzed...
From 1994 to 2005, the Pediatric Perioperative Cardiac Arrest Registry collected data on 373 anesthesia-related cardiac arrests (CAs) in children, 34% of whom had congenital or acquired heart disease (HD).Nearly 80 North American institutions that provide anesthesia for children voluntarily enrolled Registry. A standardized form each perioperative CA 18 years old younger was submitted anonymously. We analyzed causes and outcomes from with without HD.Compared 245 HD, 127 HD who arrested were...
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD progression characterized by stereotyped accumulation proteinopathies, affected cellular populations remain understudied. Here we use multiomics, spatial genomics and reference atlases from BRAIN Initiative to study middle temporal gyrus cell types 84 donors with varying pathologies. This cohort includes 33 male 51 female donors, an average age at time death 88 years. We used quantitative neuropathology...
Alzheimer's disease (AD) is the most common cause of dementia in older adults. Neuropathological and imaging studies have demonstrated a progressive stereotyped accumulation protein aggregates, but underlying molecular cellular mechanisms driving AD progression vulnerable cell populations affected by remain coarsely understood. The current study harnesses single spatial genomics tools knowledge from BRAIN Initiative Cell Census Network to understand impact on middle temporal gyrus types. We...
Abstract Alzheimer’s disease (AD) is the most common cause of dementia in older adults. Neuropathological and imaging studies have demonstrated a progressive stereotyped accumulation protein aggregates, but underlying molecular cellular mechanisms driving AD progression vulnerable cell populations affected by remain coarsely understood. The current study harnesses single spatial genomics tools knowledge from BRAIN Initiative Cell Census Network to understand impact on middle temporal gyrus...
Abstract Molecular heterogeneity in human breast cancer has challenged diagnosis, prognosis, and clinical treatment. It is well known that molecular subtypes of tumors are associated with significant differences prognosis survival. Assuming the attributed to subtype-specific pathways, we then suspect there might be gene regulatory mechanisms modulate behavior pathways their interactions. In this study, proposed an integrated methodology, including machine learning information theory, explore...
Abstract Background: RNA-Seq is a powerful technology for accurately quantifying the transcriptome of human cancers. The breast cancer section TCGA has generated data over 950 samples from primary tumors and adjacent normal tissues. Analysis these provided insights into transcript isoforms gene fusions related to etiology cancer. These rich no doubt contain other expression genes how it relates clinical outcomes. Methods: were downloaded portal. A total 712 available when this project...
Abstract Background While traditional histologic neuropathological assessment of neurodegenerative disease has tremendous diagnostic value, insights into neurodegeneration’s pathophysiological underpinnings can be significantly enhanced with large‐scale quantitative analyses. As part the Seattle Alzheimer’s Disease Brain Cell Atlas (SEA‐AD), we present a neuropathology dataset across 84 brains spanning spectrum AD neuropathologic change donated by UW Research Center and Adult Changes in...
Abstract Background Applications of ex vivo magnetic resonance imaging (MRI) human brain tissue from autopsy has grown in recent years and can provide useful information that is complementary to data neuropathological evaluations. We sought evaluate relationship between gray matter (GM) white (WM) volumes Alzheimer’s Disease Neuropathologic Change Score (ADNC) the Adult Changes Thought (ACT) cohort. Method GM WM volumetric for 33 regions interests (ROIs) were derived using FreeSurfer each...
Abstract Background The trace of memory has not been well studied in middle temporal gyrus (MTG). Although neuronal loss is minimal most cortical regions the aging brain, changes synaptic physiology ageing neurons may contribute to altered connectivity. In Adult Changes Thought (ACT) autopsy cohort, we explored if decline associated with NeuN (neuronal nuclear protein), a biomarker for mature neurons, MTG. Method ACT study participants were 5,763 older adults randomly sampled from an...