Kelly Meyers
A5102896738- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Alzheimer's disease research and treatments
- Anesthesia and Sedative Agents
- Heart Failure Treatment and Management
- Dementia and Cognitive Impairment Research
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Acute Myocardial Infarction Research
- Chronic Disease Management Strategies
Kaiser Permanente Washington Health Research Institute
2022-2024
Children's Hospital of Philadelphia
2020
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD progression characterized by stereotyped accumulation proteinopathies, affected cellular populations remain understudied. Here we use multiomics, spatial genomics and reference atlases from BRAIN Initiative to study middle temporal gyrus cell types 84 donors with varying pathologies. This cohort includes 33 male 51 female donors, an average age at time death 88 years. We used quantitative neuropathology...
Alzheimer's disease (AD) is the most common cause of dementia in older adults. Neuropathological and imaging studies have demonstrated a progressive stereotyped accumulation protein aggregates, but underlying molecular cellular mechanisms driving AD progression vulnerable cell populations affected by remain coarsely understood. The current study harnesses single spatial genomics tools knowledge from BRAIN Initiative Cell Census Network to understand impact on middle temporal gyrus types. We...
Abstract Alzheimer’s disease (AD) is the most common cause of dementia in older adults. Neuropathological and imaging studies have demonstrated a progressive stereotyped accumulation protein aggregates, but underlying molecular cellular mechanisms driving AD progression vulnerable cell populations affected by remain coarsely understood. The current study harnesses single spatial genomics tools knowledge from BRAIN Initiative Cell Census Network to understand impact on middle temporal gyrus...
To estimate the positive predictive value (PPV) of International Classification Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) diagnosis codes for identifying HF subtypes.We validated ICD-10-CM among Kaiser Permanente Washington enrollees who were ≥18 years age and had an code during 2017-2018 a procedure echocardiogram in 12 months before through 6 after code. Left ventricular ejection fraction (LVEF) ascertained from medical chart review was used as gold standard classifying...