A5041119904- Coronary Interventions and Diagnostics
- Angiogenesis and VEGF in Cancer
- Cardiovascular and exercise physiology
- Peripheral Artery Disease Management
- Aortic aneurysm repair treatments
- Thermoregulation and physiological responses
- Diabetic Foot Ulcer Assessment and Management
- Congenital heart defects research
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular and Diving-Related Complications
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Vascular Procedures and Complications
- Electrospun Nanofibers in Biomedical Applications
- Systemic Lupus Erythematosus Research
- Cardiac and Coronary Surgery Techniques
- Infectious Aortic and Vascular Conditions
- Stroke Rehabilitation and Recovery
- Acute Ischemic Stroke Management
- Atherosclerosis and Cardiovascular Diseases
- Nuclear Receptors and Signaling
- Exercise and Physiological Responses
- Coronary Artery Anomalies
University of Eastern Finland
2014-2025
Kuopio University Hospital
2023-2024
University of Salford
2016
Clinical management of critical limb-threatening ischaemia (CLTI) is focused on prevention and treatment atherosclerotic arterial occlusions. The role microvascular pathology in disease progression still largely unspecified more importantly not utilized for treatment. aim this explorative study was to characterize the microvasculature CLTI pathology.
Coronary stenting operations have become the main option for treatment of coronary heart disease. Vessel recovery after has emerged as a critical factor in reducing possible complications. In this study, we evaluated feasibility, safety and efficacy locally administered intraluminal gene therapy delivered using specialized infusion balloon catheter.
Abstract Tissue microvasculature is known to remodel in response ischemia. Yet, how this remodeling contributes the process of post-ischemic recovery still not completely understood. We studied microvascular changes relate muscle repair. Muscle-level alterations blood flow and hemoglobin oxygenation, myofiber capillary responses were analyzed aged, healthy C57Bl/6J mice (n = 48) hyperlipidemic LDLR −/− ApoB 100/100 69) after induction acute hindlimb ischemia using contrast ultrasound,...
Percutaneous coronary intervention is routinely performed to treat occlusive artery disease. Coronary perforation a potential complication and can be treated with stent graft. Current grafts are associated high restenosis rates. We tested the safety feasibility of biodegradable in pig rabbit models.Stent were examined coronaries repeated OCT imaging for 42 days. Novel coatings applied on bare metal by either an electrospinning (ES) or dip coating (DC) method. A completely system was made ES...
This study aimed to show the significance of capillary function in post-ischemic recovery from perspective physiological parameters, such as blood flow, hemoglobin oxygenation and tissue regeneration. Muscle-level microvascular alterations flow oxygenation, myofiber responses were analyzed aged, healthy C57Bl/6J mice (n = 48) hyperlipidemic LDLR−/−ApoB100/100 69) after induction acute hindlimb ischemia using contrast ultrasound, photoacoustic imaging histological analyses, respectively. The...
Abstract Background We have recently established hypoxic microvascular remodelling as a critical pathomechanistic factor that limits oxygen diffusion to muscle in chronic limb threatening ischaemia (CLTI). Using animal models of experimental hind we also displayed the biological relevance post-ischaemic skeletal muscle. Our results indicate differential changes associate damage and repair. The natural dynamics inherently promote recovery are defected CLTI patients. Particularly, progressive...
Introduction: Angiogenic gene therapy has shown potential for treatment of peripheral ischemic diseases in animal models but unfortunately clinical trials have failed to show consistent improvements patients. We hypothesized that the differential outcomes and could be explained by pathological differences between human disease.
We aimed to increase stent endothelialization with gene therapy known promote endothelial proliferation. In addition, we evaluated OCT and angioscopy imaging as tools for detecting endothelium comparison robust ex-vivo analyses including scanning electron microscopy (SEM), multiphoton immunohistology. 24 stents, BMS DES, were implanted into naïve porcine coronary arteries received either AdVEGF-A or control AdLacZ a porous drug delivery catheter. Stents imaged in-vivo angiography,...
Abstract The tissue microvasculature is known to remodel in response ischemia. However, the benefit or harm of this process not completely understood and may limit also potential taking control ischemic diseases that remain leading cause death worldwide. In a series clinical preclinical studies, we have thus dissected biological relevance pathomechanistic role hypoxic microvascular remodeling critical limb threatening ischemia (CLTI). High-resolution contrast enhanced ultrasound was used 50...