A5030124374- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Natural Compound Pharmacology Studies
- Cell death mechanisms and regulation
- Phytochemicals and Antioxidant Activities
- Bioactive Compounds and Antitumor Agents
- Nitric Oxide and Endothelin Effects
- Cancer-related Molecular Pathways
- Redox biology and oxidative stress
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced Breast Cancer Therapies
- Bioactive natural compounds
- Complement system in diseases
- Acute Myeloid Leukemia Research
- Erythrocyte Function and Pathophysiology
- Immunotherapy and Immune Responses
- Chronic Myeloid Leukemia Treatments
- Protein Tyrosine Phosphatases
- Drug Transport and Resistance Mechanisms
- Calcium signaling and nucleotide metabolism
- Sirtuins and Resveratrol in Medicine
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Sorbonne Université
2007-2023
Assistance Publique – Hôpitaux de Paris
2014-2023
Inserm
2003-2021
Université Paris Cité
2006-2021
Délégation Paris 5
2016-2021
Sorbonne Paris Cité
2015-2021
Centre de Recherche des Cordeliers
2004-2021
Pitié-Salpêtrière Hospital
2014-2020
University College Cork
2008-2010
Background Chronic lymphocytic leukemia (CLL), the most common adulthood leukemia, is characterized by accumulation of abnormal CD5+ B lymphocytes, which results in a progressive failure immune system. Despite intense research efforts, drug resistance remains major cause treatment CLL, particularly patients with dysfunctional TP53. The objective our work was to identify potential approaches that might overcome CLL refractoriness examining pro-apoptotic targeting cell surface receptor CD47...
Thrombospondin-1 (TSP-1) is a glycoprotein considered as key actor within the tumor microenvironment. Its binding to CD47, cell surface receptor, triggers programmed death. Previous studies allowed identification of 4N1K decapeptide derived from TSP-1/CD47 epitope. Here, we demonstrate that this peptide able induce selective apoptosis various cancer lines while sparing normal cells. A structure–activity relationship study led design first serum stable TSP-1 mimetic agonist trigger death...
We showed previously that hyperforin (HF), a natural phloroglucinol, stimulated apoptosis in B cell chronic lymphocytic leukaemia cells (CLL) and displayed anti-angiogenic properties. In the present work, we investigated effects of on activity P-gp/MDR1, an ABC (ATP-binding cassette) transporter putatively involved multidrug resistance (MDR). Ex vivo treatment CLL with HF markedly impaired P-gp, as measured by inhibition capacity treated to efflux rhodamine 123 probe. addition, most...
Besides their antiviral and immunomodulatory functions, type I (α/β) II (γ) interferons (IFNs) exhibit either beneficial or detrimental effects on tumor progression. Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of abnormal CD5+ B lymphocytes that escape death. Drug resistance disease relapse still occur in CLL. The triggering IFN receptors believed to be involved survival CLL cells, but underlying molecular mechanisms are not yet characterized. We show here both...
The resistance to apoptosis of chronic lymphocytic leukemia (CLL) cells partly results from the deregulated production survival signals leukemic cells. Despite development new therapies in CLL, drug and disease relapse still occur. Recently, neutrophil gelatinase-associated lipocalin (NGAL), a secreted glycoprotein, has been suggested have critical role biology tumors. Thus, we investigated relevance NGAL CLL pathogenesis, analyzed expression its cellular receptor (NGAL-R) on malignant B...
Allogeneic hematopoietic stem cell transplantation (HSCT) remains a potentially curative and useful strategy in high-risk relapsing CLL. Minimal Residual Disease (MRD) assessment at 12 months post-HSCT is predictive of relapse. This phase 2 study aimed to achieve M12 MRD negativity (MRDneg) using MRD-driven immune-intervention (Md-PII) algorithm based on serial flow-cytometry blood MRD, involving cyclosporine tapering followed if failure by donor lymphocytes infusions. Patients had CLL...
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of neoplastic B lymphocytes that escape death, and correlates with expression negative prognostic markers such as CD38 antigen. Although certain new drugs approved US Food Drug Administration improve clinical outcome CLL patients, drug resistance disease relapse still occur. Like CD38, neutrophil gelatinase-associated lipocalin receptor (NGAL-R) frequently overexpressed in cells. Here, we evaluated concomitant surface...
Downregulation of iNOS and NO is a pathway common for flavones polyphenols, two distinct families phytoalexins. Our data suggest that inhibition the could be one mechanisms involved in proapoptotic properties these phytoalexins leukemia B-cells.