A5036393710- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Tryptophan and brain disorders
- Pregnancy and preeclampsia studies
- Maternal Mental Health During Pregnancy and Postpartum
- Endometrial and Cervical Cancer Treatments
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Pregnancy-related medical research
- Pregnancy and Medication Impact
- Metabolism, Diabetes, and Cancer
- Bone fractures and treatments
- Immune Cell Function and Interaction
- Connective Tissue Growth Factor Research
- Lung Cancer Treatments and Mutations
- Neonatal Respiratory Health Research
- Graphene research and applications
- Data Quality and Management
- COVID-19 Impact on Reproduction
- Graphene and Nanomaterials Applications
- Ginseng Biological Effects and Applications
- Blood Coagulation and Thrombosis Mechanisms
- MicroRNA in disease regulation
- Phagocytosis and Immune Regulation
Obstetrics and Gynecology Hospital of Fudan University
2017-2024
Fudan University
2018-2023
Baoding University
2023
Shanghai Institute of Planned Parenthood Research
2018-2021
Qilu University of Technology
2020
Nanjing Medical University
2018
Endometriosis is a common estrogen-dependent condition that impacts 8–10% of women in their reproductive age, resulting notable pain, morbidity, and infertility. Despite extensive research endeavors, the precise cause endometriosis remains elusive, mechanisms contributing to its associated infertility are still not well comprehended. Natural killer (NK) cells, vital innate immune cells crucial for successful pregnancy, have been investigated potential involvement pathogenesis endometriosis....
The crosstalk between trophoblast cells and decidual NK plays an important role in the establishment maintenance of normal pregnancy. Recent studies reported that autophagy can induce immune tolerance at maternal fetal interface, while mechanism remains unclear.Autophagy levels villi recurrent spontaneous abortion (RSA) patients were detected by transmission electron microscopy. After co-cultured with pretreated 3-MA or rapamycin, collected expression killer receptors was flow cytometry...
Background: Cervical cancer is a common malignant disease in female patients accompanied by activation of autophagy tumor cells. However, the exact regulatory factors and its effects on immune response remain unknown. Methods: The induction HeLa SiHa cells treated with IFN-γ, tryptophan depletion, kynurenine epacadostat was detected western blot analysis an detection kit. Following co-culture pre-treated cells, U937 were analyzed flow cytometry to detect CD80, CD86, CD163 CD206 expression...
Introduction Recurrent implantation failure (RIF) is a frustrating challenge because the cause unknown. The current study aims to identify differentially expressed genes (DEGs) in endometrium on basis of immune cell infiltration characteristics between RIF patients and healthy controls, as well investigate potential prognostic markers RIF. Methods GSE103465, GSE111974 datasets from Gene Expression Omnibus database were obtained screen DEGs control groups. Ontology analysis, Kyoto...
Abstract Prostacyclin (PGI 2 ) plays key roles in shaping the immune microenvironment and modulating vasodilation, whereas its contribution to endometriosis (EMs) remains largely unclear. Our study suggested that prostacyclin synthase (PTGIS)-dependent PGI signaling was significantly activated EMs, which involved hypoxic of ectopic lesions deficient methylation status PTGIS promoter. Notably, vitro assays, hypoxia promoted expression through DNA methyltransferase 1 (DNMT1)-mediated...
It has been reported that the impaired cytotoxicity of natural killer (NK) cells and abnormal cytokines are changed by interaction between ectopic endometrial immune is indispensable for initiation development endometriosis (EMS). However, mechanism NK dysfunction in EMS remains largely unclear. Here, we found peritoneal fluid from women with highly expressed indoleamine 2,3-dioxygenase (IDO). Furthermore, IDO+NK possessed lower NKp46 NKG2D but higher IL-10 than IDO-NK. Co-culture stromal...
Heme oxygenase 1 (HO-1, encoded by the HMOX1 gene) is rate-limiting enzyme that catalyzes heme degradation, and it has been reported to exert antioxidative effects. Recently, decidualization confer resistance environmental stress signals, protecting against oxidative stress. However, effects regulatory mechanism of HO-1 in decidual stromal cells (DSCs) during early pregnancy remain unknown. Here, we verified levels DSCs are increased compared with those endometrial cells. Additionally,...
The state of self-renewal and self-maintain decidual macrophages would be important for immune homeostasis at the maternal-fetal interface. roles interleukin (IL)-24 derived from stromal cells (DSCs) on have not been explored.IL-24 expression in DSCs was interfered by lentivirus, transcription levels IL-24 were verified real time (RT)-PCR. receptors determined flow cytometry assays. effect recombination human (rhIL-24) differentiation apoptosis analyzed vitro. viability detected Cell...
Recurrent spontaneous abortion (RSA) is a common health problem that affects about 5% of fertile women, when it occurs for unknown reasons, called unexplained recurrent (URSA). Traditional Chinese medicine, such as Bu-Shen-Yi-Qi formula which consists Dangshen, Tusizi, Baizhu, Baishuo, Duzhong, Sangjisheng, Sugeng, and Tiaohuangqin, has played an invaluable role in the treatment RSA since ancient times. However, mechanism how takes effect still not clear. To identify could modulate immune...
Endometrial hyperplasia (EH) is characterized by an endometrial gland-to-stroma ratio >1 and one of the most common gynecological diseases in world. The role immunocyte subsets development EH remains unknown.Patients who underwent dilatation curettage due to abnormal uterine bleeding were recruited present study. Alterations numbers different types immune cell endometrium patients analyzed flow cytometry.The study included 48 divided into three groups, based on pathological results: (a)...
Pregnancy is a complicated process with intricate cell-to-cell crosstalk and immune regulation. Decidual natural killer (NK) cells account for 50%-70% of decidual in early pregnancy, suggesting that they play important roles various events, such as embryo implantation vascular remodeling. Many studies have shown NK interact other either through direct contact or the secretion factors cytokines chemokines. Hence, this review aimed to present phenotypic characteristics, classification,...
The objective of this study was to identify the risk factors for postoperative pathological escalation endometrial cancer in patients with a pathologic diagnosis intraepithelial neoplasia (EIN) before surgery. Some clues from preoperative assessment were used build nomogram predict likely after surgery, and explore feasibility sentinel lymph node biopsy these possible escalation.
Objective: To investigate whether kynurenine/aryl hydrocarbon receptor (AHR) affects the maternal-fetal tolerance by involving differentiation of T helper 17 (Th17)/ regulatory (Treg) cells, and to provide theoretical basic for new treatment unexplained abortion. Methods: Flow cytometry (FCM) was used detect expression AHR in peripheral/decidual CD4+ T, Treg, Th17 cells. The effect Kyn on naïve T-cells under Treg-/Th17-polarizing condition detected FCM; enzyme-linked immunosorbent assay...
Abstract Corncob and Graphene oxide were used to prepare characterize corncob/graphene (GO/CC) composites. The adsorption performance of GO/CC on dye wastewater was studied, the factors affecting effect investigated. results showed that had rich functional groups which could provide sufficient binding sites for Congo red. It remove red solution strongly, removal rate as high 80%. GO/SP endothermic in process adsorption. reaction mainly based chemical
With the continuous application and popularization of big data technology, all government departments are aware importance as a national basic strategic resource, over country have been promoting sharing opening (SOA) local (GA) one after another, improving organization, formulating regulations, building GA SOA platform. At present, kept separately in each department, while there is no good DS scheme, resulting low (DS), lack authenticity shared data, easy leakage difficulty tracking....
Aspirin, one of the most widely applied medicines, not only possesses effects on reducing fever, anti-vascular hyperplasia, and anti-inflammation, but also has capacity preventing platelet aggregation. So far, it is acceptable to adopt aspirin, especially low-dose aspirin (LDA), prevent pregnancy-related complications, such as pregnancy complicated by antiphospholipid syndrome, systemic lupus erythematosus, or preeclampsia; unexplained recurrent spontaneous abortion; fetal growth...