A5090575652- Phytochemicals and Medicinal Plants
- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Neuroprotection
- Vitamin K Research Studies
- Cholinesterase and Neurodegenerative Diseases
- Natural Antidiabetic Agents Studies
- Natural product bioactivities and synthesis
- Dermatologic Treatments and Research
- Plant-based Medicinal Research
- Diverse Scientific Research Studies
- Skin Protection and Aging
- Essential Oils and Antimicrobial Activity
- Moringa oleifera research and applications
- Pharmacogenetics and Drug Metabolism
- Vitamin C and Antioxidants Research
- Toxin Mechanisms and Immunotoxins
- Synthesis and biological activity
- melanin and skin pigmentation
- Steroid Chemistry and Biochemistry
- Hibiscus Plant Research Studies
- Protein Hydrolysis and Bioactive Peptides
- Phytochemistry and Bioactivity Studies
- Phytochemistry and biological activity of medicinal plants
Alexandria University
2017-2024
Selective factor Xa inhibitors effectively block coagulation cascade with a broader therapeutic window than multitargeted anticoagulants. They have evolved as crucial part of prevention and treatment thromboembolic diseases in protocols involved many clinical trials coronavirus disease 2019 (COVID-19) patients. Biologically-guided isolation specific FXa from licorice (Glycyrrhiza glabra) root extract furnished ten flavonoids. By detailed analysis their 1H, 13C NMR MS data, the structures...
Withania somnifera popularly known as ashwaganda or Indian Ginseng is a well plant in India. Furthermore, it common Egypt. The objective of this study to evaluate the effectiveness extracts different parts protection against oxidative stress and its therapeutic potential treatment Alzheimer’s. All tested showed significant anticholinesterase activity, with highest activity produced by ripe fruit extract, nitric oxide scavenging strong haemolysis antioxidant activity. Unlike that reputed for...
Human adenovirus type-7 (HAdV-7) is a common pathogen that may cause significant morbidity as well severe complications. Currently, there no approved drug for the treatment of HAdV-7 infections and contemporary strategy mainly rely on nonspecific antivirals. Glycyrrhiza glabra; (licorice), well-recognized edible plant used in food beverages. The renowned its pharmacological biological activities including antiviral against wide range viruses. following study reported first time...
Seven compounds were isolated from the leaves and fruits of Egyptian Withania somnifera dunal, (Family: Solanaceae). The identity based on their spectroscopic data as follows: two withanolides; withaperuvin C (1), phyperunolideF (2) four lipids;1,2-di-O-palmitoyl-3-O-(6´´´-sulfo-α-D-quinovopyranosyl)-glycerol (3), vaccenic acid (5), 1,3 dicaproyl,2-vaccenoyl-glycerol (6), vaccenolymonoglyceride (7) β-sitosterol glucoside (4). All metabolites except (4) reported for first time this plant....
A sensitive, reliable, simple and rapid thin-layer chromatographic method has been developed for routine analysis of withanolide S content the purpose quality control assessment chemotype III Withania somnifera. The new was used first to compare accumulation in different parts plant, which found be highest leaves extract (0.21% w/w). Second, investigate extraction parameters that improve efficiency withanolides from using conventional ultrasound-assisted methods. expressed via total content.
Virtual screening (VS) techniques have emerged in the past decade as an efficient strategy lead identification. Molecular docking well pharmacophore and 3D-QSAR modelling are two major VS standing out cornerstones process of new drug discovery. Explanation main virtual most commonly used validation parameters discussed thoroughly emphasizing their use shortcomings. Criteria for selection benchmarking datasets training sets molecular docking, pharmacophore, models discussed. Understanding...
Anticoagulation therapy represents a mainstay of treatment and prevention cardiovascular diseases which are the leading causes mortality worldwide. In addition, several case reports spontaneous bleeding occurred linking consumption many dietary supplements during with anticoagulants or in postoperative patients. This prompted our study is conducted on eleven well-known Egyptian medicinal plants to highlight their effect blood coagulation profile using Prothrombin time (PT) activated partial...
Background: An investigative study of Egyptian W. somnifera revealed that the plant belongs to chemotype uioIII and having 20-hydroxywithanolides with α -oriented side chain.Aim: Test whether Withania family Solanaceae cultivated in Egypt can be used for pharmaceutical industry.Materials Methods: accurate TLC method was developed is introduced evaluation this chemotype.Cell viability assay showed ethanolic extracts leaves produce significant anticancer effect liver breast cancer cell...