A5061542767- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Sesquiterpenes and Asteraceae Studies
- Plant biochemistry and biosynthesis
- Phytochemicals and Medicinal Plants
- Computational Drug Discovery Methods
- Biological Activity of Diterpenoids and Biflavonoids
- Analytical Chemistry and Chromatography
- Traditional and Medicinal Uses of Annonaceae
- Inorganic and Organometallic Chemistry
- Plant Toxicity and Pharmacological Properties
- Spectroscopy and Chemometric Analyses
- Phytochemistry and Bioactive Compounds
- Essential Oils and Antimicrobial Activity
- Cynara cardunculus studies
- Drug-Induced Hepatotoxicity and Protection
- Bioactive Natural Diterpenoids Research
- Crystallization and Solubility Studies
- Neutropenia and Cancer Infections
- Silymarin and Mushroom Poisoning
- Cassava research and cyanide
- Pharmacological Effects of Medicinal Plants
- Vitamin K Research Studies
- Diverse Scientific Research Studies
- Steroid Chemistry and Biochemistry
Imam Abdulrahman Bin Faisal University
2025
Alexandria University
1997-2024
Children Cancer Hospital
2022-2023
King Saud University
1986-1991
Instituto de Química Orgánica General
1991
University of Palermo
1991
Technische Universität Berlin
1989
COVID-19 vaccines are crucial to control the pandemic and avoid severe infections. The rapid evolution of variants such as B.1.1.529 is alarming, especially with gradual decrease in serum antibody levels vaccinated individuals. Middle Eastern countries were less likely accept initial doses vaccines. This study was directed determine vaccine booster acceptance its associated factors general population MENA region attain public herd immunity. We conducted an online survey five (Egypt, Iraq,...
Four new sesquiterpene derivatives have been isolated from the aerial parts of Cleome droserifolia. Their structures were established as 6-di(7-hydroxy, 1, 5-epoxy germacrane) (2), 4(15)-guaiane-6-ol (3), 7alpha-germacra-1(10), 4(15)-diene-5beta, 6alpha-diol (4) and 4,7,8-eudesma-triol (5). In addition, a dolabellane diterpene derivative with naturally rare peroxy function was identified methyl ester...
Selective factor Xa inhibitors effectively block coagulation cascade with a broader therapeutic window than multitargeted anticoagulants. They have evolved as crucial part of prevention and treatment thromboembolic diseases in protocols involved many clinical trials coronavirus disease 2019 (COVID-19) patients. Biologically-guided isolation specific FXa from licorice (Glycyrrhiza glabra) root extract furnished ten flavonoids. By detailed analysis their 1H, 13C NMR MS data, the structures...
In an attempt to confront the growing problem of liver diseases in Egypt and worldwide, some plants belonging tribe Cynareae were evaluated for their hepatoprotective activities. The aerial parts Carduus getulus, Centaurea alexandrina, calcitrapa, Cynara cornigera Onopordum alexandrinum, leaves scolymus seeds C. O. alexandrinum selected present study. ethanol extract stated six subjected assays using Wistar albino rats at doses 500 250 mg/kg, depending on case. injury was induced carbon...
Summary A high performance liquid chromatographic method was developed for the quantitative determination of active components silymarin in leaves Silybum marianum during different growth stages. In this study, taxifolin and six main constituents silymarin, including silydianin, silychristin, diastereomers silybin (silybin B) isosilybin (isosilybin were completely separated on a 5-μm ODS column (Luna, Phenomenex, USA) with mobile phase consisting methanol 5 mM NaH2PO4 (pH 3.5 adjusted...
Seven compounds were isolated from the leaves and fruits of Egyptian Withania somnifera dunal, (Family: Solanaceae). The identity based on their spectroscopic data as follows: two withanolides; withaperuvin C (1), phyperunolideF (2) four lipids;1,2-di-O-palmitoyl-3-O-(6´´´-sulfo-α-D-quinovopyranosyl)-glycerol (3), vaccenic acid (5), 1,3 dicaproyl,2-vaccenoyl-glycerol (6), vaccenolymonoglyceride (7) β-sitosterol glucoside (4). All metabolites except (4) reported for first time this plant....
A sensitive, reliable, simple and rapid thin-layer chromatographic method has been developed for routine analysis of withanolide S content the purpose quality control assessment chemotype III Withania somnifera. The new was used first to compare accumulation in different parts plant, which found be highest leaves extract (0.21% w/w). Second, investigate extraction parameters that improve efficiency withanolides from using conventional ultrasound-assisted methods. expressed via total content.
Three diterpenoid dolabellane esters were isolated from Cleome droserifolia. The chemical structures of the compounds determined by spectral as well methods. These dolabellanes (I, II and III) are ester derivatives 3-hydroxy-3-methyl glutaric acid (3-HMGA). Compounds I have second (3HMGA) carboxyl function free, while compound III is methyl I. This first report isolation this class genus a natural source. In addition, eight flavone isolated.