A5049969782- Microscopic Colitis
- Inflammatory Bowel Disease
- Coronary Interventions and Diagnostics
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Diagnosis and treatment of tuberculosis
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- Acute Myocardial Infarction Research
- Mycobacterium research and diagnosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Eosinophilic Esophagitis
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Pancreatitis Pathology and Treatment
- Diverticular Disease and Complications
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
- Skin Protection and Aging
- Eosinophilic Disorders and Syndromes
- Medical and Biological Ozone Research
- Viral gastroenteritis research and epidemiology
- Blood donation and transfusion practices
- Gastrointestinal Bleeding Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
Griffith University
2019-2025
Sunshine Coast University Hospital
2024-2025
Gold Coast Hospital
2018-2025
Bond University
2018-2025
Queensland Health
2019
University of the South Pacific - Solomon Islands Campus
2019
We aimed to determine whether changes in acute severe colitis (ASC) management have translated improved outcomes and develop a simple model predicting steroid non-response on admission.Outcomes of 131 adult ASC admissions (117 patients) Oxford, UK between 2015 2019 were compared with data from 1992 1993. All patients received standard treatment intravenous corticosteroids endoscopic disease activity scoring (Ulcerative Colitis Endoscopic Index Severity (UCEIS)). Steroid was defined as...
Dasatinib is a common treatment for chronic myeloid leukaemia with numerous side effects including gastrointestinal. We report woman in her 50s who presented haematochezia, weight loss and positive faecal occult blood test. She was being treated dasatinib without the use of any concurrent medications, non-steroidal anti-inflammatory drugs. Initial colonoscopy demonstrated moderate patchy left-sided inflammation, biopsies revealing mild inflammation prominent eosinophilia. subsequently...
Abstract Background Acute Severe Ulcerative Colitis (ASUC) is a medical emergency, with limited therapeutic options available for management. Tofacitinib and Upadacitinib are novel Janus Kinase inhibitors (JAKi), proven efficacy ulcerative colitis (UC). This study aimed to examine the outcomes of patients treated JAKi ASUC in real-world population. Methods A retrospective multi-centre was conducted including (≥18 years) commenced on or from April 2021 2024. defined according Truelove Witt’s...
Abstract Background Medical rescue therapy (MRT) is effective in intravenous corticosteroid refractory acute severe ulcerative colitis (ASUC). Our primary objective was to identify parameters which initial and sustained response MRT. Methods Two cohorts were studied retrospectively. Analysis of 66 adult ASUC admissions receiving MRT between 2015-19 at Gold Coast University Hospital Logan first performed. Clinical, endoscopic laboratory data collected. Response defined as avoiding colectomy...
Spontaneous splenic rupture (SSR) is an exceptionally rare and life-threatening condition, with its pathophysiology remaining poorly understood. This report describes the first documented case of SSR in a patient Q fever infection underlying liver cirrhosis portal hypertension. The was man his late 30 s who presented severe abdominal pain, vomiting hypovolemic shock required emergency splenectomy due to unstable hemorrhage. Post-operatively, diagnosis confirmed through serological testing....
Quality metrics for Barrett's esophagus (BE) are anticipated to improve outcomes patients through earlier detection of neoplasia. The European Society Gastrointestinal Endoscopy has developed guidelines homogenize endoscopic quality in BE. Our study aimed assess the impact recommended key performance measures (KPMs) and their sustainability. A single-center, retrospective (Phase 1) was conducted over 8 weeks. KPMs assessed were: pre-procedure including indication, consent, safety checklist...
Sweet’s syndrome is an acute febrile neutrophilic dermatosis. Drug-induced typically occurs soon after drug administration, with rapid resolution of symptoms cessation the offending agent. We report a man in his early 40s who presented fever and widespread erythematous rash on background recently diagnosed mild stricturing ileal Crohn’s disease. He was commenced 6-mercaptopurine 12 days before presentation. Skin biopsy demonstrated diffuse infiltration neutrophils upper dermis, dermal...
Tamoxifen is a non-steroidal selective oestrogen receptor modulator commonly used in the treatment of breast cancer. It associated with development fatty liver and steatohepatitis however drug-induced injury rare. We report woman her 50s who developed malaise an acute moderate aminotransferase elevation without jaundice 6 months after starting tamoxifen. She was not commenced on any other recent drugs extensive investigation including infective autoimmune screen, cross-sectional imaging...
Vedolizumab is used in the treatment of inflammatory bowel disease and generally well tolerated. We report a 20-year-old man who presented with right flank pain on background ulcerative colitis. He was vedolizumab his last dose 1 week before onset symptoms. Kidney function tests revealed serum creatinine 171 μmoL/L C-reactive protein 74 mg/L. biopsy demonstrated focal acute interstitial nephritis. prescribed oral prednisolone achieved complete recovery renal within 3 weeks. At follow-up...
There is paucity of data on outcomes acute severe ulcerative colitis (ASUC) in older adults (≥ 60 years age).
Abstract Background Improving the quality of colonoscopy in inflammatory bowel disease is expected to improve clinical outcomes for patients. The European Society Gastrointestinal Endoscopy (ESGE) recently published key performance measures IBD assessment. This study aimed assess impact implementing and sustainable improvement through a multimodal education intervention. Methods A baseline retrospective analysis was performed patients with established between June August 2022 at tertiary...
Abstract Background Medical rescue therapy (MRT) is effective in intravenous corticosteroid refractory acute severe ulcerative colitis (ASUC). We recently described the ADMIT-ASC score to identify patients on admission at high risk of steroid failure. In this setting, our primary objective analysis now parameters which could non-response MRT, following Co-primary develop and validate a model non-responders MRT. Methods Two cohorts were studied, for discovery validation. Retrospective 66...
Aims Sessile serrated lesions (SSL) are known precursors for colorectal cancer. Their prevalence varies across populations. We aimed to investigate their and characteristics in the Australian population. In particular, we assessed younger cohort follow up findings of patients identified have at least one SSL index colonoscopy.
Aims Improving the quality of colonoscopy in inflammatory bowel disease is expected to improve clinical outcomes for patients. The European Society Gastrointestinal Endoscopy (ESGE) recently published key performance measures IBD assessment. This study aimed assess impact implementing and sustainable improvement through a multimodal education intervention.
Transjugular intrahepatic portosystemic shunt (TIPS) is an important therapy for complications of portal hypertension but remains underutilised in regional settings.