A5078633700- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- Global Cancer Incidence and Screening
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Economic and Financial Impacts of Cancer
- Cancer-related molecular mechanisms research
- Nutrition, Genetics, and Disease
- RNA Research and Splicing
- Skin and Cellular Biology Research
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- Developmental Biology and Gene Regulation
- Immune Response and Inflammation
- Healthcare Systems and Reforms
- Kruppel-like factors research
- Global Healthcare and Medical Tourism
- Health Systems, Economic Evaluations, Quality of Life
- Brain Metastases and Treatment
- PARP inhibition in cancer therapy
- NF-κB Signaling Pathways
- T-cell and B-cell Immunology
I-Shou University
2020-2025
Institute of Biomedical Sciences, Academia Sinica
2012-2020
National Defense Medical Center
2009-2020
Nantong Tumor Hospital
2018
Institute of Life Sciences
2012
Taipei Veterans General Hospital
2012
Background: The prognostic impact of internal carotid artery (ICA) invasion in nasopharyngeal cancer (NPC) patients is not well established. Thus, we conducted a retrospective study to analyze the factors for ICA by NPC. Methods: This included consecutive biopsy-proven NPC who received CCRT from November 2015 December 2022 at E-Da Hospital. Patients were then classified into two groups according tumor or not. Survival was estimated Kaplan–Meier method with five-year overall survival (OS)...
Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-B pathway. By querying GENT2 datasets, we identified gene expression level of TLR2 and TLR4 as being substantially increased colorectal cancer. Introduction shRNAs for but not dramatically recovered disialyl Lewisa sialyl 6-sulfo Lewisx glycans, which are preferentially expressed non-malignant colonic epithelial cells could serve ligands immunosuppressive molecule Siglec-7. We screened...
During epidermal cell differentiation, keratin 14 (K14) expression is down-regulated, p53 varies, and the of target genes, p21 14-3-3σ, increases. These trends suggest that relative transcriptional activity increased during differentiation. To determine relationship between K14 p53, we constructed promoters various sizes found wild-type could repress promoter all constructs in H1299 cells. K14-p160 contains an SP1 binding site mutation prevents from repressing expression. Using a DNA...
The consensus sequence of p53 is repeated half sites PuPuPuC(A/T)(A/T)GPyPyPy. GtAGCAttAGCCCAGACATGTCC a 14-3-3σ promoter regulation site; the first core CAttAG, and second CATG. Both mutants GtAGgAttAGCCCAGACATGTCC GtAGCAttAGCCCAGACATcTCC can be activated by as 1.5-fold site. original regulated site on whole site, CATTAG functional sequence. p53-binding affinity activity were lower than for mutant CATATG Wild-type acts tetramer to bind however, it also one its dimers. only with CATG but not...
The p53 family has the following three members: p53, p63 and p73. is a tumor suppressor gene that frequently exhibits mutation in head neck cancer. Most mutants are loss-of-function (LoF) mutants, but some acquire oncogenic function, such as gain of function (GoF). It known aggregation mutant can induce GoF. p73 activators RETRA NSC59984 have an anti-cancer effect cells, we found were not effective all squamous cell carcinoma (HNSCC) lines, with different mutants. A comparison expression...
Abstract More than 50% of colon cancers bear mutations in p53, one the most important tumor suppressors, and its family members p63 or p73 are expected to contribute inhibiting progression cancers. The AP2 also acts as a suppressor. Here we found that able activate NEU4, neuraminidase gene, which removes terminal sialic acid residues from cancer-associated glycans. Under serum starvation, NEU4 was up-regulated target glycans, sialyl Lewis X, decreased, whereas were up-regulated. Sialyl X...
Journal Article A half-site of the p53-binding site on keratin 14 promoter is specifically activated by p63 Get access Bi-He Cai, Cai 1Institute Life Sciences; 2Department Biology and Anatomy, National Defense Medical Center, Taipei 114, Taiwan; 3Division Plastic Surgery, Shin Kong Wu Ho-Su Memorial Hospital, 111, Taiwan, ROC Search for other works this author on: Oxford Academic PubMed Google Scholar Chung-Faye Chao, Chao Mei-Hua Lu, Lu Hwang-Chi Lin, Lin Jang-Yi Chen * *Jang-Yi Chen,...
Objective: To explore the sustainability of cancer screening strategy from potential demander's perspective in Chinese country, we conducted a study on use services and willingness-to-pay among urban community residents. All participants this had not been Cancer Screening Program Urban China (CanSPUC) or any other national level projects. Methods: Target communities populations were selected 16 project provinces which program between 2014 2015, by using multi-center cross-sectional...
(1) Background: PTC124 (Ataluren) is an investigational drug for the treatment of nonsense mutation-mediated genetic diseases. With exception TP53 tumor suppressor gene, there has been little research on cancers with mutation. By conducting a database search, we found that another two genes, NOTCH1 and FAT1, have high mutation rate in head neck squamous cell carcinoma (HNSCC). may re-express functional or FAT1 HSNCC (2) Methods: DOK (with Y550X) HO-1-u-1 E378X) HNSCC cells were treated...
B3GALT5 is involved in the synthesis of embryonic stem (ES) cell marker glycan, stage-specific antigen-3 (SSEA3). This gene has three native promoters and an integrated retroviral long terminal repeat (LTR) promoter. We found that B3GALT5-LTR expressed at high levels human ES cells. also cancer-associated sialyl Lewis a. Sialyl a cells its expression decreases upon differentiation. Retinoic acid induced differentiation cells, decreased short form NFYA (NFYAs), increased phosphorylation...
The canonical core sequence of the p53 response element, CATG, has a two-base A/T gap. Previously, we found that can also activate non-canonical four-base gap CATATG sequence. In this study, investigated possible number bases used by and showed six-base CATATATG was maximum in element could be upregulated p63. Canonical elements have three-base flanking sequences. substituted G/C bases, including CACACG CGTGTG, but not CGCGCG. We SV40 promoter with functional six- sequences activated TAp63γ...
Objective: From an actual cancer screening service demanders' perspective, we tried to understand the preference on frequency and willingness-to-pay for packaging program common cancers evaluate its long-term sustainability in urban populations China. Methods: 2012 2014, a multi-center cross-sectional survey was conducted among participants from 13 provinces covered by Cancer Screening Program Urban China (CanSPUC). By face-to-face interview, information regarding frequency, program, maximum...
Objective: Based on the investment for potential suppliers of cancer screening services, we assessed reasons that affecting their participation motivation related to long-term sustainability in China. Methods: Hospitals had never been involved any national level project were selected by using convenient sampling method within 16 cities Cancer Screening Program Urban China (CanSPUC) with 1 or 2 hospitals each city. All managers from institutional/department and professional staff working...
Objective: To understand the constituent and workload of service providers engaged in cancer screening China provide evidence for assessment sustainability national project. Methods: Using either questionnaire or online approach, survey was conducted 16 provinces, where Cancer Screening Program Urban (CanSPUC) conducted, from 2014 to 2015. The medical institutes surveyed included hospitals [71.1% were class Ⅲ(A) hospitals], centers disease control prevention (CDCs) community undertaken...
Objective: To understand the acceptance and personal demand for cancer screening service among urban residents who had never been involved in any national level programs China identify key factors influencing sustainability of screening. Methods: A questionnaire survey was conducted local people aged 40-69 years selected through convenience sampling 16 provinces to collect general information about their demands others. Results: total 394 qualified questionnaires were completed. The average...
(1) Background: A premature termination codon (PTC) can be induced by a type of point mutation known as nonsense mutation, which occurs within the coding region. Approximately 3.8% human cancer patients have mutations p53. However, non-aminoglycoside drug PTC124 has shown potential to promote PTC readthrough and rescue full-length proteins. The COSMIC database contains 201 types p53 in cancers. We built simple affordable method create different clones for study activity PTC124. (2) Methods:...