Mohamed M. Nasef

ORCID: 0000-0003-4228-7671
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Research Areas
  • Saffron Plant Research Studies
  • Flavonoids in Medical Research
  • Process Optimization and Integration
  • Cancer, Lipids, and Metabolism
  • Electrochemical sensors and biosensors
  • Autophagy in Disease and Therapy
  • Advanced Control Systems Optimization
  • Advanced Nanomaterials in Catalysis
  • Advanced biosensing and bioanalysis techniques
  • Pharmacological Effects of Medicinal Plants
  • Nanoparticle-Based Drug Delivery
  • MicroRNA in disease regulation
  • Cannabis and Cannabinoid Research
  • Natural product bioactivities and synthesis
  • Endometriosis Research and Treatment
  • Curcumin's Biomedical Applications
  • Phytochemical and Pharmacological Studies
  • Nanoplatforms for cancer theranostics
  • Liver Disease and Transplantation
  • Biological Activity of Diterpenoids and Biflavonoids
  • Kruppel-like factors research
  • Probiotics and Fermented Foods
  • Clostridium difficile and Clostridium perfringens research
  • Pancreatic function and diabetes
  • Moringa oleifera research and applications

University of Huddersfield
2020-2025

University of Technology Malaysia
2014

Angiogenesis and metastasis play pivotal roles in the progression of cancer. We recently discovered that crocin, a dietary carotenoid derived from Himalayan crocus, inhibited growth colon cancer cells. However, exact role crocin on angiogenesis colorectal remains unclear. In present study, we demonstrated significantly reduces viability cells (HT-29, Caco-2) human umbilical vein endothelial (HUVEC), but was not toxic to epithelial (HCEC) Furthermore, pre-treatment carcinoma (HT-29 with cell...

10.3390/cells11091502 article EN cc-by Cells 2022-04-29

Piceatannol (PIC) is known to have anticancer activity, which has been attributed its ability block the proliferation of cancer cells via suppression NF-kB signaling pathway. However, effect on hypoxia-inducible factor (HIF) not well in cancer. In this study, PIC was loaded into bovine serum albumin (BSA) by desolvation method as PIC-BSA nanoparticles (NPs). These were assessed for vitro cytotoxicity, migration, invasion, and colony formation studies levels p65 HIF-1α. Our results indicate...

10.3390/cancers12010113 article EN Cancers 2020-01-01

Pancreatic cancer is one of the fatal causes global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In present study, we investigated anti-pancreatic amelioration radiation-induced oxidative damage by crocin. Crocin carotenoid isolated from dietary herb saffron, prospect for novel leads as an anti-cancer agent. significantly reduced cell viability BXPC3 Capan-2 triggering caspase signaling via...

10.3390/nu12061901 article EN Nutrients 2020-06-26

Abstract A mathematical model for an ultrasound-assisted vapor liquid equilibrium (VLE) system developed in Aspen Custom Modeler is exported to Plus flowsheeting environment form a block the software library represent single stage flash separation unit. The then arranged series mimic ultrasonically intensified distillation process. As case study, ethanol/ethyl acetate process examined. results show that 99 mol% ethyl recovery established when of 27 VLE devices are used. also evaluated other...

10.1515/cppm-2015-0003 article EN Chemical Product and Process Modeling 2015-10-15

Aim: To investigate the potential anti-inflammatory and biochemical effects of Moringa peregrina leaf extracts on testosterone-induced benign prostatic hyperplasia (BPH) in rats. Methods: Six groups rats (each group included 5 rats) were this study. The included: 1) control group, 2) BPH 3) with 50 mg/kg bwt (bodyweight) oil-treated BPH, 4) 100 bwt. 5) 500mg/kg ethanol treated 6) 1,000 aqueous group. Biochemical markers measured to evaluate effect M. extracts. Results: Our results showed a...

10.31557/apjcp.2022.23.1.161 article EN cc-by Asian Pacific Journal of Cancer Prevention 2022-01-01

The performance of an ultrasonic distillation (USD) system is evaluated in Aspen Plus simulation environment. To facilitate the flowsheet development, a mathematical model single stage USD developed using Custom Modeler software exported to process simulator. As case study, separation ethanol-ethyl acetate mixture that known form azeotrope 55 mole % ethyl at minimum boiling point 71.8 o C considered. Simulation results revealed achievable purity 99 from azeotropic mixture, thus reinforcing...

10.4028/www.scientific.net/amm.625.677 article EN Applied Mechanics and Materials 2014-09-12
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