A5047869985- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- DNA Repair Mechanisms
- Folate and B Vitamins Research
- Metabolism and Genetic Disorders
- Sperm and Testicular Function
- Catalytic C–H Functionalization Methods
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- BRCA gene mutations in cancer
- Bacteriophages and microbial interactions
- Synthesis and Characterization of Heterocyclic Compounds
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Catalytic Cross-Coupling Reactions
- Reproductive Biology and Fertility
- Biomedical and Engineering Education
- Prostate Cancer Treatment and Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- SARS-CoV-2 and COVID-19 Research
- Chronic Kidney Disease and Diabetes
- Saffron Plant Research Studies
- Glutathione Transferases and Polymorphisms
- Biosensors and Analytical Detection
- Essential Oils and Antimicrobial Activity
Yarmouk University
2015-2025
Ben-Gurion University of the Negev
2025
Jordan University of Science and Technology
2020-2022
Helwan University
2021
Faculty (United Kingdom)
2021
University of Benghazi
2019
University of Pisa
2013-2017
Thomas Jefferson University
2012-2015
Sidney Kimmel Cancer Center
2012-2013
Philadelphia University
2012-2013
(1) Background: There is a growing need for the development of new methods synthesis nanoparticles. The interest in such particles has raised concerns about environmental safety their production methods; (2) Objectives: current nanoparticle are often expensive and employ chemicals that potentially harmful to environment, which calls "greener" protocols. Herein we describe gold nanoparticles (AuNPs) using plant extracts, offers an alternative, efficient, inexpensive, environmentally friendly...
Previously, we proposed a new paradigm to explain the compartment-specific role of autophagy in tumor metabolism. In this model, and mitochondrial dysfunction stroma promotes cellular catabolism, which results production recycled nutrients. These chemical building blocks high-energy “fuels” would then drive anabolic growth tumors, via resistance oxidative metabolism cancer cells. We have termed form stromal-epithelial metabolic coupling: “two-compartment metabolism.” Here, stringently tested...
Piceatannol (PIC) is known to have anticancer activity, which has been attributed its ability block the proliferation of cancer cells via suppression NF-kB signaling pathway. However, effect on hypoxia-inducible factor (HIF) not well in cancer. In this study, PIC was loaded into bovine serum albumin (BSA) by desolvation method as PIC-BSA nanoparticles (NPs). These were assessed for vitro cytotoxicity, migration, invasion, and colony formation studies levels p65 HIF-1α. Our results indicate...
Several studies have reported the anti-diabetic effect of biologically synthesized gold nanoparticles (AuNPs). This study was designed to investigate in vivo activity AuNPs using leaf extract Dittrichia viscosa a high-fat diet (HFD)/streptozotocin (STZ)-induced diabetes rats. were D. viscosa, and characterized by UV-visible spectrophotometer, dynamic light scattering (DLS), zeta potential, transmission electron microscopy (TEM). To anti-hyperglycemic formed extract, adult male Sprague-Dawley...
Chronic use of synthetic cannabinoids (SCs) has been associated with cognitive and behavioural deficits an increased risk neuropsychiatric disorders. The underlying molecular cellular mechanisms the neurotoxic effects long-term SCs have not well investigated in literature. Herein, we evaluated vivo chronic administration AB-FUBINACA on hippocampus mice. Our results revealed that induced a significant impairment recognition memory histopathological changes hippocampus. These findings were...
Cigarette smoke has been directly implicated in the disease pathogenesis of a plethora different human cancer subtypes, including breast cancers. The prevailing view is that cigarette acts as mutagen and DNA damaging agent normal epithelial cells, driving tumor initiation. However, its potential negative metabolic effects on stromal microenvironment have largely ignored. Here, we propose new mechanism by which carcinogen-rich may promote growth, metabolically "fertilizing" host...
Pancreatic cancer is one of the fatal causes global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In present study, we investigated anti-pancreatic amelioration radiation-induced oxidative damage by crocin. Crocin carotenoid isolated from dietary herb saffron, prospect for novel leads as an anti-cancer agent. significantly reduced cell viability BXPC3 Capan-2 triggering caspase signaling via...
Several recent studies have reported that gold nanoparticles (AuNPs) attenuate hyperglycemia in diabetic animal models without any observed side effects. The present study was intended to provide insight into the effects of 50-nm AuNPs on kidney disease. Adult male rats were divided three groups (n = 7/group): control (non-diabetic, ND), (D), and treated intraperitoneally with (AuNPs + D; 2.5 mg/kg/day) for 7 weeks. Diabetes induced by a single-dose injection 55 mg/kg streptozotocin. result...
Although tobacco smoking declined among men at reproductive age, the use of cannabis increased. The aim our study was to determine impact and on sperm quality, DNA integrity tested by Chromomycin A3 (CMA3) acridine orange (AO) their association genetic variants in Cytochrome C Oxidase 1, 2 3 genes (MT-CO1, MT-CO2, MT-CO3). Semen samples were collected divided into 37 non-smokers (NS), 39 smokers (TS), (CS). MT-CO1, MT-CO2 MT-CO3 amplified PCR sequenced Sanger. results showed reductions...
In the original publication [...]
Chemical modification of the surface viruses, both interior and exterior, imparts new functionalities, that have potential applications in nanomedicine. In this study, we developed novel virus-based nanomaterials as a contrast agent for computed tomography (CT) imaging vitro. The gold-coated cowpea mosaic virus (Au-CPMV) particles were generated by electrostatic adsorption positively charged electrolyte on capsid with subsequent incubation reduction anionic gold complexes. Au-CPMV CT offer...
Here, we described the synthesis of novel pyrazole-s-triazine derivatives via an easy one-pot procedure for reaction β-dicarbonyl compounds (ethylacetoacetate, 5,5-dimethyl-1,3-cyclohexadione or 1,3-cyclohexadionone) with N,N-dimethylformamide dimethylacetal, followed by addition 2-hydrazinyl-4,6-disubstituted-s-triazine either in ethanol-acetic acid neat acetic to afford a pyrazole and pyrazole-fused cycloalkanone systems. The synthetic protocol proved be efficient, shorter time high...
Background: Gold nanoparticles (AuNps) are promising agents for prostate cancer therapy. Herein, the in vivo effects of 20 and 50 nm sized AuNps on experimentally induced benign prostatic hyperplasia (BPH) was examined. Materials methods: Adult male rats were divided into four groups (n=6–8 each). A negative control group three injected daily with testosterone (3 mg/kg/subcutaneously) to induce BPH. Animals receiving randomized untreated BPH two which treated intraperitoneally (5...
This study examines the effect of nanoparticles with zinc oxides (ZnONPs) on diabetic nephropathy, which is primary cause mortality for patients end-stage renal disease. Diabetes in adult male rats was induced via intraperitoneal injection streptozotocin. ZnONPs were intraperitoneally administered to daily 7 weeks. associated increases blood glucose level, 24-h urinary albumin excretion rate, glomerular basement membrane thickness, oxidative stress markers, and mRNA or protein expression...