A5046469152- Drug Transport and Resistance Mechanisms
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- HIV/AIDS drug development and treatment
- Analytical Chemistry and Chromatography
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Lipid metabolism and disorders
- HIV Research and Treatment
- Diabetes Treatment and Management
- Memory and Neural Mechanisms
- Traditional Chinese Medicine Studies
- HIV-related health complications and treatments
- Statistical Methods in Clinical Trials
- Mycobacterium research and diagnosis
- Peptidase Inhibition and Analysis
- Pharmacological Effects and Toxicity Studies
- Receptor Mechanisms and Signaling
- Pharmacy and Medical Practices
- Adipose Tissue and Metabolism
- Nanoparticle-Based Drug Delivery
- Chemical Synthesis and Analysis
- Bacterial Identification and Susceptibility Testing
- Erythrocyte Function and Pathophysiology
- Mitochondrial Function and Pathology
Sumitomo Dainippon Pharma (Japan)
2014-2024
Kyoto Pharmaceutical University
2003-2004
Understanding the relationship between concentration of a drug and its therapeutic efficacy or side effects is crucial in development, especially to understand central nervous system drug, quantifying drug-induced site-specific changes levels endogenous metabolites, such as neurotransmitters. In recent times, evaluation quantitative distribution drugs metabolites using matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry imaging (MSI) has attracted much attention discovery...
Huntington's disease (HD) is a progressive, neurodegenerative characterized by motor, cognitive, and psychiatric symptoms. To investigate the metabolic alterations that occur in HD, here we examined plasma whole-brain metabolomic profiles of R6/2 mouse model HD. Plasma brain analyses were conducted using capillary electrophoresis-mass spectrometry (CE-MS). In addition, liquid chromatography-mass (LC-MS) was also applied to analyses, cover broad range metabolites with various physical...
Although alcohol consumption is a factor in which the bioavailability of saquinavir (SQV) are retarded, cause for this phenomenon remains to be uncertain. In presence study, we examined factors decrease plasma concentration SQV ethanol-treated rats. The rats were prepared by making them freely access 15% ethanol solution 14 d (Day rats). exsorption clearance from blood circulation jejunal lumen Day increased 6-fold as compared non-treated (NT) 25 μM ketoconazole (KCZ) or 10 cyclosporin A...
To elucidate drug interaction between human immunodeficiency virus (HIV) protease inhibitors (PIs), the effect of indinavir (IDV) on intestinal exsorption other HIV PIs, amprenavir (APV), saquinavir (SQV) and nelfinavir (NFV) was investigated in rats using an situ single perfusion method. IDV perfusate inhibited rhodamine 123 (Rho123), a known P-glycoprotein (P-gp) substrate, from blood into lumen concentration-dependent manner, inhibitory potency 10 micro M close to that cyclosporin A (CsA)...
In 1998, we developed a Total Infection Control System in Saga Medical School Hospital, and would like to introduce it for the practical use.This system was named “Dr. FLEMING” (Flexible Microbiological Test & Information New Generation) is expected help physicians by providing highly valuable test results useful information. For example, bacterial identification drug susceptibility can be completed within 4-6hrs after colony isolated, report contains full-colored pictures enhance...