A5071135696- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Thermal Regulation in Medicine
- Neuroscience and Neuropharmacology Research
- Thermoregulation and physiological responses
- Electronic Health Records Systems
- Intensive Care Unit Cognitive Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Ultrasound in Clinical Applications
- Biomedical Text Mining and Ontologies
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Clinical Nutrition and Gastroenterology
- Neonatal and fetal brain pathology
- Diet and metabolism studies
- Disaster Response and Management
- Family and Patient Care in Intensive Care Units
- Vascular Procedures and Complications
- Ion channel regulation and function
- Radiology practices and education
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Central Venous Catheters and Hemodialysis
- Airway Management and Intubation Techniques
Beth Israel Deaconess Medical Center
2017-2024
Harvard University
2017-2024
Massachusetts General Hospital
2020
Spaulding Rehabilitation Hospital
2020
Pain and Rehabilitation Medicine
2020
Hadassah Medical Center
2018
Barro Colorado Island
2018
University of New Mexico
2016
Soroka Medical Center
2008-2013
Ben-Gurion University of the Negev
2008-2013
Background Decreasing blood glutamate concentrations after traumatic brain injury accelerates brain-to-blood efflux, leading to improved neurologic outcomes. The authors hypothesize that treatment with scavengers should reduce neuronal cell loss, whereas administration of worsen performed histologic studies survival in the rat hippocampus and scavengers. Methods Traumatic was induced on anesthetized male Sprague-Dawley rats by a standardized weight drop. Intravenous groups included saline...
Although real-time ultrasound guidance during central venous catheter insertion has become a standard of care, postinsertion chest radiograph remains the gold to confirm tip position and rule out associated lung complications like pneumothorax. We hypothesize that combination transthoracic echocardiography is noninferior when used accurately assess positioning screen for pneumothorax.All operating rooms surgical trauma ICUs at institution.Single-center, prospective noninferiority...
Excessive concentrations of L-glutamate (glutamate) have been found to posses neurotoxic properties. This study investigates how stress induced by strong physical exercise effects blood glutamate, 2-ketoglutarate, Alanine aminotransferase (ALT) and Aspartate Aminotransferase (AST) levels. The relationship between muscle damage caused glutamate levels was also examined. Twenty-two healthy volunteers engaged in intense veloergometry (“spinning”) for a duration 60 minutes. Two 10 minute peaks...
Background: Isoflurane-anesthetized rats subjected to traumatic brain injury (TBI) show a transient reduction in blood L-glutamate levels. Having previously observed that isoproterenol produces sustained decrease glutamate levels naive rats, we investigated the possible effects of nonselective and selective β1 β2 adrenergic agonists antagonists both on neurological outcomes TBI. Methods: Rats received either 10 mL/kg isotonic saline 1 hour after TBI, 50 µg/kg pretreatment 30 minutes before...
Preparedness measures for the anticipated surge of coronavirus disease 2019 (COVID-19) cases within eastern Massachusetts included establishment alternate care sites (field hospitals). Boston Hope hospital was set up Convention and Exhibition Center to provide low-acuity COVID-19 patients support local healthcare systems. However, early recognition need higher levels care, or critical potential deterioration recovering from COVID-19, prompted development a hybrid acute care–intensive unit....
Rapid weight loss or “weight cutting” is a dangerous practice that ubiquitous in modern combat sports yet underrepresented the medical literature. We present case of exertional rhabdomyolysis mixed martial artist with sickle cell trait to illustrate hazards cutting and ensuing critical illness. Sickle known predispose patients rhabdomyolysis, multiple fatal cases have been reported setting strenuous exercise. Dehydration consequent electrolyte abnormalities make sport athletes particularly...
Anesthetized rats were assigned to sham; brain injury (BI); controlled hemorrhagic shock (CHS); BI combined with CHS (combined [CI]); and CI groups resuscitated 2.5 mL/kg Ringer's lactate solution (RL-2.5), 10 RL (RL-10), or 40 (RL-40). Brain was induced by applying 400 millibar negative pressure for s through a hollow screw inserted into 4.5-mm burr hole drilled the left parietal region of skull. Five minutes after BI, 30% circulating blood volume withdrawn min induce CHS. One hour fluid...
In Brief INTRODUCTION: Glutamate neurotoxicity is determined by the balance between glutamate release within brain and efflux of excess from brain. Brain-to-blood increased decreasing concentration in blood. Little known about effect hyperthermia on blood concentrations, effectiveness glutamate–decreasing mechanisms these conditions. Although hypothesized to decrease concentrations activation stress mechanisms, blunting response blocking β-adrenergic receptors should prevent this decrease....
Treatment of combined traumatic brain injury and hypovolemic shock poses a particular challenge due to the possible conflicting consequences. While restoring diminished volume is treatment goal for hypovolemia, maintaining adequate cerebral perfusion pressure avoidance secondary damage remain injured brain. Various modalities have been proposed, but optimal resuscitation fluid goals not yet clearly defined. In this study, we investigate physiological neurological outcomes in rat model shock,...
Rapid weight loss or “weight cutting” is a common but potentially harmful practice used in mixed martial arts competition. Following the official weigh-in, competitors refeed and rehydrate themselves process known as rapid gain (RWG) to realize potential competitive advantage. While data from surveys small series have indicated majority of athletes engage loss, there lack officially collected sanctioning organizations describing its prevalence. The present investigation represents summary...