A5032948110- Extracellular vesicles in disease
- Pregnancy and preeclampsia studies
- Photoacoustic and Ultrasonic Imaging
- Reproductive System and Pregnancy
- Nanoplatforms for cancer theranostics
- Connexins and lens biology
- Maternal and fetal healthcare
- Birth, Development, and Health
Carnegie Mellon University
2021-2024
The relationship between maternal monocytes and the placenta is crucial for successful pregnancy. As existing reviews focus on research decidual macrophages or Hofbauer cells (fetal macrophages), we conducted a scoping review of literature studies examining circulating villous trophoblast. goal this was to outline within field, disseminate further information, identify current knowledge gaps field. We searched PubMed (MEDLINE) database relevant articles published since 1995 that studied...
Abstract Ischemic stroke causes brain endothelial cell (BEC) death and damages tight junction integrity of the blood-brain barrier (BBB). We harnessed innate mitochondrial load cell-derived extracellular vesicles (EVs) utilized mixtures EV/exogenous heat shock protein 27 (HSP27) as a one-two punch strategy to increase BEC survival (via EV mitochondria) preserve their HSP27 effects). demonstrated that medium-to-large (m/lEV) but not small EVs (sEV) transferred load, which subsequently...
Abstract Introduction Pregnancy-related disorders such as preeclampsia are associated with syncytiotrophoblast (STB) stress and monocyte dysregulation. It remains unclear whether this derives from prolonged placental hypoxia or a hypoxia-reperfusion-type injury. Thus, study investigated how these two models of STB impact trophoblast-monocyte interactions. Method Cobalt chloride chemically induced in BeWo b30 cells. A transwell coculture system was used to examine signaling. qPCR quantified...