Embelin, a quinone derivative, is found in the fruits of Embelia ribes Burm (Myrsinaceae). It has been shown to have variety therapeutic potentials including anthelmintic, anti-tumor, anti-diabetic, anti-bacterial and anti-inflammation. Inflammation an immunological response external harmful stimuli regulated by endogenous pyrogen pleiotropic pro-inflammatory cytokine, tumor necrosis factor alpha (TNF-α). TNF-α production implicated other human pathologies neurodegeneration cancer. Several...

Glioblastomas (GBMs) represent the most aggressive form of brain tumor arising from malignant transformation astrocytes. Despite various advancements, treatment options remain limited to chemotherapy and radiotherapy followed by surgery giving an overall survival 14–15 months. These therapies are somewhere restricted in a better cure. There is need for new therapeutics that could potentially target GBM based on molecular pathways pathology. Here, ubiquitin E3 ligases can be used as targets...

Tuberculosis has become a major health problem being the second leading cause of death worldwide. Mycobacterium tuberculosis secretes virulence factor, protein tyrosine phosphatase B (mPTPB) in cytoplasm host macrophage which suppresses its natural innate immune response and helps pathogen survive proliferate phagosome. The present study aims at indentifying potent inhibitors mPTPB by using computational approaches ligand based molecular modeling docking studies.A 3D QSAR model was developed...

Oxidative stress is a major cellular burden that triggers reactive oxygen species (ROS) and antioxidants modulate signalling mechanisms. Byproducts generated from this process govern the brain pathology functions in various neurological diseases. As oxidative remains key therapeutic target disease, it necessary to explore multiple routes can significantly repair damage caused due ROS consequently, neurodegenerative disorders (NDDs). Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase...

Background Because of limitations medical treatment in vitiligo, various surgical techniques have been devised. There is a scarcity comparative studies vitiligo. Objective To compare the effectiveness and side-effect profile flip-top transplantation (FTT) punch grafting (PG) patients with stable Materials Methods Twenty vitiligo were treated using PG FTT on 26 lesions; 156 grafts taken (78 PG, 78 grafts). They graded for response form repigmentation as excellent (91–100%), very good...

Epidermodysplasia verruciformis (EV) is a rare, inherited disorder that predisposes patients to widespread human papillomavirus (HPV) infection and cutaneous squamous cell carcinomas. There still no definitive therapeutic modality for EV. A 24 year old male patient with EV was treated oral zinc sulphate, one of the cheapest safe immuno-modulator available as agent satisfactory result.

There have been rare published cases of discoid lupus erythematosus (DLE) with other autoimmune cutaneous and systemic disorders. We describe a 36 years old female patient DLE lesions on the face hands coexistence lip-tip vitiligo hypothyroidism. discuss how treatment has to be modified innovative in presence these three coexisting disorders dermatologist should do this get successful outcome.

Insomnia is one of the most common clinical problems being faced by people all over world. It adversely affects routine life these patients giving rise to even other health issues like hypertension, diabetes, obesity, depression, heart attack, and stroke. Orexin receptor-1 (OX1R), a noteworthy drug target, when inhibited can promote sleepiness in suffering from such conditions. OX1R G-protein coupled receptor which conserved throughout mammalian species located primarily hypothalamus locus...

Sports injuries are the second most common type of accident after domestic (3.7%) and occupational accidents (3.1%). There is an average annual estimate 8.6 million sports recreational related injury incidents with age-adjusted rate 34.1 per 1000 populations. Common musculoskeletal i.e. Sprains, Strains, Joint injuries, soft tissue (STI). The in Ayurveda can be co-related within dissimilar facets trauma ailments. To evaluate efficacy a protocol-based management using integrated approach....

Pityriasis versicolor is a common fungal infection of the skin which leads to formation scaly and discoloured small lesions on skin. The main objective this study describe clinical mycological characteristics predisposing factors in patients with pityriasis versicolor.In prospective, observational, hospital-based cross-sectional study, all ages clinically suspected were included. After detailed history thorough examination, scrapings examined 10% potassium hydroxide (KOH) under light...

Punctate palmoplantar keratoderma (Brauer-Buschke-Fischer syndrome) is a rare entity. Among punctate keratoderma, the linear presentation much rarer, and exact incidence not known. Unilateral yet reported in literature. Here we report case 12-year-old child presented with asymptomatic plaque on left sole hand; histology revealed hyperkeratotic epidermis without columns of parakeratosis or cornoid lamella.

Diagnosis of pigmented lesions the mouth and oral mucosal tissues is challenging. Even though epidemiology may be some help in orientating clinician even can diagnosed on clinical grounds alone, definitive diagnosis requires histopathological examination. We report a case fungiform papillae tongue secondary to iron deficiency anaemia. After extensive literature search we found very few cases due anaemia paediatric population. Hence here 12-year-old male presented with patchy areas his 4...

Sarcoidosis is a multisystem granulomatous disease which frequently affects young adults. Because of its rarity, the exact incidence and prevalence childhood sarcoidosis not known. It mostly children older age group i.e., 13-15 years. Early onset (<5 years) characterized by triad arthritis, uveitis rash. Late present with similar to adults, frequent pulmonary infiltrations lymphadenopathy. Herein, we report case early-onset in four-year-old female along uncommon clinical features like...

Syphilis is re-emerging as a leading sexually transmitted disease among patients living with acquired immune deficiency syndrome [AIDS]. Dental practitioners are very often seen oral abnormality in the form of palatal perforation but it unlikely to see sole manifestation tertiary syphilis. Here we present 36 years old male patient presented hard palate without any other or systemic complaints. Purpose this case report aware dentist about emergence syphilis cause cavity ailment.

The hernial sac does not play a crucial role in the problem of hernia. Hence ligation this should be taken as an axiomatic step. We have operated on 30 patients (Continuous study) aged between 6 months to 60 years, where has been ligated but only divided at level deep inguinal ring. peritoneum was then allowed fall back and standard Bassini's repair using 2/0 Prolene done each case except 5 children no such done. In study, severity pain into mild requiring drug, moderate oral drugs severe...