A5086047246- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Cellular transport and secretion
- CRISPR and Genetic Engineering
- Tea Polyphenols and Effects
- Retinal Development and Disorders
- Parasites and Host Interactions
- Viral Infectious Diseases and Gene Expression in Insects
- Photoreceptor and optogenetics research
- Peptidase Inhibition and Analysis
- Coffee research and impacts
- Lysosomal Storage Disorders Research
- Galectins and Cancer Biology
- Biotin and Related Studies
- Phytochemical compounds biological activities
- Insect symbiosis and bacterial influences
University of California, Los Angeles
2018-2021
Smith-Kettlewell Eye Research Institute
2021
University of California, San Diego
2021
Clemson University
2012-2018
African trypanosomes, Trypanosoma brucei spp., are lethal pathogens that cause substantial human suffering and limit economic development in some of the world's most impoverished regions. The name ("auger cell") derives from parasite's distinctive motility, which is driven by a single flagellum. However, despite decades study, requirement for trypanosome motility mammalian host infection has not been established. LC1 conserved dynein subunit required flagellar motility. Prior studies with...
Human pluripotent stem cells (PSCs) represent a powerful tool to investigate human eye development and disease. When grown in 3D, they can self-assemble into laminar organized retinas; however, variation the size, shape composition of individual organoids exists. Neither microenvironment nor timing critical growth factors driving retinogenesis are fully understood. To explore early retinal development, we developed SIX6-GFP reporter that enabled systematic optimization conditions promote...
Sleeping sickness is a neglected tropical disease caused by the protozoan parasite Trypanosoma brucei . The disrupts sleep-wake cycle, leading to coma and death if left untreated. T. motility, transmission, virulence depend on its flagellum (cilium), which consists of several different specialized subdomains.
The current pharmacopeia to treat the lethal human and animal diseases caused by protozoan parasite Trypanosoma brucei remains limited. parasite's ability undergo antigenic variation represents a considerable barrier vaccine development, making identification of new drug targets extremely important. Recent studies have demonstrated that fatty acid synthesis is important for growth virulence brucei, suggesting this pathway may therapeutic potential. first committed step catalyzed acetyl-CoA...
To satisfy its fatty acid needs, the extracellular eukaryotic parasite Trypanosoma brucei relies on two mechanisms: uptake of acids from host and de novo synthesis. We hypothesized that T. modulates synthesis in response to environmental lipid availability. The first committed step is catalyzed by acetyl coenzyme A (acetyl-CoA) carboxylase (ACC) serves as a key regulatory point other organisms. test our hypothesis, mammalian bloodstream insect procyclic forms were grown low-, normal-, or...
ABSTRACT Trypanosoma brucei is the protozoan parasite responsible for sleeping sickness, a lethal vector-borne disease. T. has single flagellum that plays critical roles in biology, transmission and pathogenesis. An emerging concept biology organelle organized into subdomains, each having specialized composition function. Overall proteome been well-studied, but gap knowledge protein of individual subdomains. We have therefore used APEX-based proximity proteomics to examine To assess...
Trypanosoma brucei , a protozoan parasite transmitted by the tsetse fly, invades bloodstream and CNS of humans, causing African sleeping sickness. In addition to antigenic variation its surface glycoprotein coat, T. employs second immune evasion tactic: upregulation endocytosis clear lytic cell complexes, strategy likely involving membrane turnover fatty acid synthesis (FAS). Acetyl‐CoA carboxylase (ACC) catalyzes first committed step FAS is regulatory control point. Previous work showed...