A5088878077- Cancer-related molecular mechanisms research
- Lysosomal Storage Disorders Research
- RNA modifications and cancer
- RNA Research and Splicing
- Chronic Myeloid Leukemia Treatments
- Skin and Cellular Biology Research
- Extracellular vesicles in disease
- Molecular Biology Techniques and Applications
- RNA regulation and disease
- Studies on Chitinases and Chitosanases
- Hematological disorders and diagnostics
- Circular RNAs in diseases
- Biotechnology and Related Fields
- Metabolism and Genetic Disorders
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- PI3K/AKT/mTOR signaling in cancer
- melanin and skin pigmentation
- Genomics and Rare Diseases
- BRCA gene mutations in cancer
- Gene expression and cancer classification
- Kruppel-like factors research
- CRISPR and Genetic Engineering
- Soil Management and Crop Yield
- Pineapple and bromelain studies
New York Hospital Queens
2017-2018
NewYork–Presbyterian Hospital
2017-2018
Cornell University
2016-2018
Presbyterian Hospital
2017-2018
Weill Cornell Medicine
2017-2018
Washington University in St. Louis
2018
Oregon Health & Science University
2018
Universidade de São Paulo
2007-2015
Hospital de Clínicas de Porto Alegre
2003-2005
National Institute on Population Medical Genetics
2004
Abstract Background RNAs transcribed from intronic regions of genes are involved in a number processes related to post-transcriptional control gene expression. However, the complement human which introns transcribed, and transcriptional units their tissue expression patterns not known. Results A survey mRNA EST public databases revealed more than 55,000 totally noncoding (TIN) 74% all unique RefSeq genes. Guided by this information, we designed an oligoarray platform containing sense...
Abstract The clear cell subtype of renal carcinoma (RCC) is the most lethal and prevalent cancer urinary system. To investigate molecular changes associated with malignant transformation in RCC, gene expression profiles matched samples tumor adjacent non‐neoplastic tissue were obtained from six patients. A custom‐built cDNA microarray platform was used, comprising 2292 probes that map to exons genes 822 for noncoding RNAs mapping intronic regions. Intronic transcription detected all normal...
Dasatinib has demonstrated efficacy in patients with chronic-phase chronic myeloid leukemia (CML) who had resistance or intolerance to imatinib. However, some also develop dasatinib. To identify potential molecular pathways involved primary dasatinib CML, we analyzed gene expression profiles of mononuclear cells 7 imatinib-resistant patients, collected before and after 1-year treatment. Large-scale was measured Agilent microarrays covering protein-coding genes long (>200 nt) noncoding RNAs...
Abstract Background: Li-Fraumeni Syndrome (LFS) is a cancer predisposition syndrome associated with TP53 germline mutations and characterized by increased risk to multiple early-onset cancers. Studies in families from Southern Southeastern Brazil have identified founder mutation the gene, p.R337H, high population prevalence (∼0.3%). Unlike majority of TP53, which are missense located DNA-binding domain (DBD) protein, p.R337H oligomerization (OD). Recently, we new rare variant, rs78378222...
Abstract A majority of B-cell lymphomas, including diffuse large lymphomas (DLBCLs) and follicular (FLs), arise from germinal center (GC) B cells. GC cells are highly proliferative manifest genomic instability as a byproduct immunoglobulin affinity maturation. These characteristics make particularly prone to malignant transformation such that DLBCLs FLs inherit dependent on mutations in proteins also required for normal For example, the BCL6 transcriptional repressor is establish phenotype...