A5084080696- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- T-cell and B-cell Immunology
- Mast cells and histamine
- CAR-T cell therapy research
- Toxoplasma gondii Research Studies
- Parvovirus B19 Infection Studies
- Asymmetric Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Coordination Chemistry and Organometallics
- HIV Research and Treatment
- Neuroblastoma Research and Treatments
- Microbial Fuel Cells and Bioremediation
- Immune cells in cancer
- Genomics, phytochemicals, and oxidative stress
- Cancer Immunotherapy and Biomarkers
- Chemical Analysis and Environmental Impact
- Immunotherapy and Immune Responses
- Food Allergy and Anaphylaxis Research
- Hematopoietic Stem Cell Transplantation
- Wastewater Treatment and Nitrogen Removal
University Medical Center of the Johannes Gutenberg University Mainz
2010-2024
Johannes Gutenberg University Mainz
2010-2024
Universitätsklinikum Würzburg
2019-2023
University of Würzburg
2015-2019
University of Bonn
1998
The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT). Indeed, specific lipids can harm CD8+ (CTL) mitochondrial integrity, leading to defective antitumor responses. However, the extent which affect CTL functions and fate remains unexplored. Here, we show that linoleic acid (LA) is positive regulator of activity by improving fitness, preventing exhaustion, stimulating memory-like phenotype with superior effector functions. We report LA treatment...
Natural killer (NK) cells and CD8(+) T play a prominent role in the clearance of mouse cytomegalovirus (MCMV) infection. The NK modulating T-cell response to MCMV infection is still subject intensive research. For analyzing impact on mounting contribution these virus control during first days postinfection (p.i.), we used C57BL/6 mice which are specifically activated through Ly49H receptor engaged by MCMV-encoded ligand m157. Our results indicate that requirement for early inversely...
Expansion of the CD8 T-cell memory pool, also known as 'memory inflation', for certain but not all viral epitopes in latently infected host tissues is a special feature immune response to cytomegalovirus. The L(d)-presented murine cytomegalovirus (mCMV) immediate-early (IE) 1 peptide prototype an epitope that associated with inflation. Based on detection IE1 transcripts lungs it was previously proposed episodes gene expression and antigenic activity due desilencing limited number genes may...
The lungs are a noted predilection site of acute, latent, and reactivated cytomegalovirus (CMV) infections. Interstitial pneumonia is the most dreaded manifestation CMV disease in immunocompromised host, whereas immunocompetent host lung-infiltrating CD8 T cells confine infection nodular inflammatory foci prevent viral pathology. By using murine as model, we provide evidence for critical role mast (MC) recruitment protective to lungs. Systemic triggered degranulation selectively infected MC....
Targeting of tumor immune escape mechanisms holds enormous therapeutic potential. Still, most patients progress under checkpoint blockade and some even become hyperprogressors. To investigate how cancer cells respond to activated but ineffective T cells, we challenged peptide-loaded MCF-7 breast with antigen-specific CD8+ in which lytic granules had been destroyed by pretreatment Concanamycin A. Gene expression analysis after coculture revealed simultaneous induction PD-L1, IDO1, CEACAM1,...
Successful reconstitution of cytomegalovirus (CMV)-specific CD8(+) T cells by hematopoietic cell transplantation (HCT) gives a favorable prognosis for the control CMV reactivation and prevention disease after hematoablative therapy malignancies. In transient immunocompromised state HCT, pre-emptive cytoimmunotherapy with viral epitope-specific effector or memory is promising option to speed up antiviral control. Despite high-coding capacity CMVs broad T-cell response on population level,...
Gene m164 of murine cytomegalovirus belongs to the large group 'private' genes that show no homology those other species and are thought represent 'host adaptation' involved in virus–host interaction. Previous interest gene product was based on presence an immunodominant CD8 T-cell epitope presented at surface infected cells, despite interference by viral immune-evasion proteins. Here, we provide data reveal shows unusual features its cell biology. A novel strategy mass-spectrometric...
Background Melanoma is a lethal skin cancer, and the risk of developing it increased by exposure to ultraviolet (UV) radiation. The production cytokines such as interleukin-15 (IL-15), induced cells UV rays, could also promote melanoma development. aim this study investigate possible role Interleukin-15/Interleukin-15 Receptor α (IL-15/IL-15Rα) complexes in Methods expression IL-15/IL-15Rα was evaluated both ex vivo vitro tissue microarray, PCR, flow cytometry. presence soluble complex...
Abstract CD8 T cells are the predominant effector of adaptive immunity in preventing cytomegalovirus (CMV) multiple-organ disease caused by cytopathogenic tissue infection. The mechanism which CMV-specific, naïve become primed and clonally expand is fundamental importance for our understanding CMV immune control. For T-cell priming, two pathways have been identified: direct antigen presentation infected professional antigen-presenting (pAPCs) cross-presentation uninfected pAPCs that take up...
CD8 T cells are the predominant effector of adaptive immunity in preventing cytomegalovirus (CMV) multiple-organ disease caused by cytopathogenic tissue infection. The mechanism which CMV-specific, naïve become primed and clonally expand is fundamental importance for our understanding CMV immune control. For T-cell priming, two pathways have been identified: direct antigen presentation infected professional antigen-presenting (pAPCs) cross-presentation uninfected pAPCs that take up antigenic...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”