A5088221098- SARS-CoV-2 and COVID-19 Research
- Heat shock proteins research
- Viral gastroenteritis research and epidemiology
- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- Seed Germination and Physiology
- Protein Degradation and Inhibitors
- COVID-19 Clinical Research Studies
- HIV/AIDS drug development and treatment
- CAR-T cell therapy research
- Light effects on plants
- Plant Molecular Biology Research
- Nuclear Structure and Function
- Immune Cell Function and Interaction
- Viral Infections and Outbreaks Research
- T-cell and B-cell Immunology
- Extracellular vesicles in disease
- IL-33, ST2, and ILC Pathways
- Animal Virus Infections Studies
- Signaling Pathways in Disease
- Eosinophilic Esophagitis
- Viral Infections and Immunology Research
- Melanoma and MAPK Pathways
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
University of Rome Tor Vergata
2019-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Bambino Gesù Children's Hospital
2023-2024
Sapienza University of Rome
2014-2015
Istituto Pasteur
2014
SARS-CoV-2, the causative agent of COVID-19, has caused an unprecedented global health crisis. The SARS-CoV-2 spike, a surface-anchored trimeric class-I fusion glycoprotein essential for viral entry, represents key target developing vaccines and therapeutics capable blocking virus invasion. emergence spike variants that facilitate spread may affect vaccine efficacy highlights need to identify novel antiviral strategies COVID-19 therapy. Here, we demonstrate nitazoxanide, antiprotozoal with...
Natural Killer (NK) cells are important components of the immune system in defense against tumor growth and metastasis. They release exosomes containing proteins nucleic acids, including microRNAs (miRNAs). NK-derived play a role anti-tumor NK cell function since they able to recognize kill cancer cells. However, involvement exosomal miRNAs is poorly understood. In this study, we explored miRNA content by microarray as compared their cellular counterparts. The expression selected lytic...
The transcription factor DOF AFFECTING GERMINATION1 (DAG1) is a repressor of the light-mediated seed germination process. DAG1 acts downstream PHYTOCHROME INTERACTING FACTOR3-LIKE 5 (PIL5), master repressor, and negatively regulates gibberellin biosynthesis by directly repressing biosynthetic gene AtGA3ox1. Dof protein GERMINATION (DAG2) shares high degree aminoacidic identity with DAG1. While inactivation considerably increases capability seeds, dag2 mutant has seeds potential substantially...
Objectives Systemic juvenile idiopathic arthritis (sJIA) is a chronic childhood disease classically attributed to innate immune cell dysregulation. This study aimed elucidate the role of lymphoid cells (ILCs), including natural killer (NK) and helper‐ILCs (hILCs), in sJIA during clinically inactive (CID) through phenotypic functional analysis. Methods Peripheral ILCs from children with CID receiving IL‐1 inhibitors (n=40) were analyzed by flow cytometry compared 23 healthy (HC) 22 patients...
Coronaviridae is recognized as one of the most rapidly evolving virus family a consequence high genomic nucleotide substitution rates and recombination. The comprises large number enveloped, positive-sense single-stranded RNA viruses, causing an array diseases varying severity in animals humans. To date, seven human coronaviruses (HCoV) have been identified, namely HCoV-229E, HCoV-NL63, HCoV-OC43 HCoV-HKU1, which are globally circulating population (seasonal HCoV, sHCoV), highly pathogenic...
The transcription factor DOF AFFECTING GERMINATION1 (DAG1) is a repressor of seed germination acting downstream the master PHYTOCROME INTERACTING FACTOR3-LIKE 5 (PIL5). Among others, PIL5 induces expression genes encoding two DELLA proteins GA INSENSITIVE 1 (GAI) and REPRESSOR OF ga1-3 (RGA).Based on properties gai-t6 rga28 mutant seeds, we show here that absence RGA severely increases dormancy, while lack GAI only partially compensates inactivation. In addition, dag1rga28 double are...
Abstract The zinc-finger AN1-type domain-2a gene, also known as AIRAP (arsenite-inducible RNA-associated protein), was initially described an arsenite-inducible gene in Caenorhabditis elegans and mammalian cells. Differently from the worm homologue, aip-1, a to play important role preserving animal lifespan buffering arsenic-induced proteotoxicity, mammals have second, constitutively expressed, AIRAP-like (AIRAPL), recently implicated myeloid transformation. We identified human canonical...
ABSTRACT SARS-CoV-2, the causative agent of COVID-19, has caused an unprecedented global health crisis. The SARS-CoV-2 spike, a surface-anchored trimeric class-I fusion-glycoprotein essential for viral entry, represents key target developing vaccines and therapeutics capable blocking virus invasion. emergence spike-variants that facilitate spread may affect vaccine efficacy highlights need to identify novel antiviral strategies COVID-19 therapy. Here we demonstrate nitazoxanide,...
Background Melanoma is a lethal skin cancer, and the risk of developing it increased by exposure to ultraviolet (UV) radiation. The production cytokines such as interleukin-15 (IL-15), induced cells UV rays, could also promote melanoma development. aim this study investigate possible role Interleukin-15/Interleukin-15 Receptor α (IL-15/IL-15Rα) complexes in Methods expression IL-15/IL-15Rα was evaluated both ex vivo vitro tissue microarray, PCR, flow cytometry. presence soluble complex...
Abstract Coronaviridae is recognized as one of the most rapidly evolving virus family a consequence high genomic nucleotide substitution rates and recombination. The comprises large number enveloped, positive-sense single-stranded RNA viruses, causing an array diseases varying severity in animals humans. To date, seven human coronaviruses (HCoV) have been identified, namely HCoV-229E, HCoV-NL63, HCoV-OC43 HCoV-HKU1, which are globally circulating population (seasonal HCoV, sHCoV), highly...
ABSTRACT Organisms respond to proteotoxic stress by activating a cellular defense mechanism, known as the heat shock response (HSR), that triggers expression of cytoprotective proteins (HSP) counteract damaging effects proteostasis disruption. The HSR is regulated family transcription factors (heat factors, HSFs); among six human HSFs, HSF1 acts guardian regulating acute and severe stress-driven transcriptional responses. Seasonal coronaviruses HCoV-229E, HCoV-NL63, HCoV-OC43 HCoV-HKU1...
<p>Supplementary Table 1. Primers and siRNAs used. Supplementary 2. Antibodies Figure S1. Effect of different proteasome inhibitors on AIRAP expression in M10 melanoma cells. S2. Intracellular localization bortezomib-treated S3. Specificity silencing human S4. AIRAP-knockdown enhances the anticancer activity bortezomib long-term treatment S5. AIRAP-silencing promotes PARP-cleavage reduces colony-forming ability cell lines. S6. inhibits A375 S7. SK-MEL-28 spheroid growth.</p>
<p>Supplementary Table 1. Primers and siRNAs used. Supplementary 2. Antibodies Figure S1. Effect of different proteasome inhibitors on AIRAP expression in M10 melanoma cells. S2. Intracellular localization bortezomib-treated S3. Specificity silencing human S4. AIRAP-knockdown enhances the anticancer activity bortezomib long-term treatment S5. AIRAP-silencing promotes PARP-cleavage reduces colony-forming ability cell lines. S6. inhibits A375 S7. SK-MEL-28 spheroid growth.</p>
<div>Abstract<p>The zinc-finger AN1-type domain-2a gene, also known as AIRAP (arsenite-inducible RNA-associated protein), was initially described an arsenite-inducible gene in <i>Caenorhabditis elegans</i> and mammalian cells. Differently from the worm homologue, <i>aip-1</i>, a to play important role preserving animal lifespan buffering arsenic-induced proteotoxicity, mammals have second, constitutively expressed, AIRAP-like (AIRAPL), recently implicated...
<div>Abstract<p>The zinc-finger AN1-type domain-2a gene, also known as AIRAP (arsenite-inducible RNA-associated protein), was initially described an arsenite-inducible gene in <i>Caenorhabditis elegans</i> and mammalian cells. Differently from the worm homologue, <i>aip-1</i>, a to play important role preserving animal lifespan buffering arsenic-induced proteotoxicity, mammals have second, constitutively expressed, AIRAP-like (AIRAPL), recently implicated...