A5059218120- Advanced Proteomics Techniques and Applications
- Genomics and Phylogenetic Studies
- Forensic Anthropology and Bioarchaeology Studies
- 14-3-3 protein interactions
- Bone and Dental Protein Studies
- Ubiquitin and proteasome pathways
- Oral microbiology and periodontitis research
- Scientific Computing and Data Management
- HIV/AIDS oral health manifestations
- Pleistocene-Era Hominins and Archaeology
- Molecular Biology Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Laser-induced spectroscopy and plasma
- Primate Behavior and Ecology
- Forensic and Genetic Research
- Glycosylation and Glycoproteins Research
- Genetics, Bioinformatics, and Biomedical Research
- Mass Spectrometry Techniques and Applications
- Microbial Natural Products and Biosynthesis
- dental development and anomalies
- Machine Learning in Bioinformatics
- Evolution and Paleontology Studies
- Genetic diversity and population structure
Max Planck Institute of Biochemistry
2018-2021
Ludwig-Maximilians-Universität München
2021
Wellcome Sanger Institute
2016-2020
University of Applied Sciences Upper Austria
2016
Red blood cell (RBC) invasion by Plasmodium merozoites requires multiple steps that are regulated signaling pathways. Exposure of P. falciparum to the physiological signal low K+, as found in plasma, leads a rise cytosolic Ca2+, which mediates microneme secretion, motility, and invasion. We have used global phosphoproteomic analysis identify pathways activated during Using quantitative phosphoproteomics, we 394 protein phosphorylation site changes subjected different ionic environments (high...
Proteogenomics leverages information derived from proteomic data to improve genome annotations. Of particular interest are “novel” peptides that provide direct evidence of protein expression for genomic regions not previously annotated as protein-coding. We present a modular, automated analysis pipeline aimed at detecting such in sets. This implements criteria developed by proteomics and annotation experts high-stringency peptide identification filtering. Our is based on the OpenMS...
Abstract We describe MaxNovo, a novel spectrum graph-based peptide de-novo sequencing algorithm integrated into the MaxQuant software. It identifies complete sequences of peptides as well sequence tags that are incomplete at one or both termini. MaxNovo searches for highest-scoring path in directed acyclic graph representing MS/MS with peaks nodes and edges potential constituents consisting single amino acids pairs. The raw score is sum node edge weights, plus several reward scores,...
These authors applied modern protein analysis to an ancient molar from a male Homo antecessor dated 772949 thousand years ago (kya) the Sierra de Atapuerca in Burgos, Spain and also dentine enamel erectus 1770 kya. They found that composition of these proteomes is similar humans, including enamel-specific amelogenin, enamelin, ameloblastin, amelotin protease matrix metalloproteinase. Indeed, they had modern-like faces with considerably deep ancestry genus Homo, cranial morphology...
Abstract Red blood cell (RBC) invasion by Plasmodium merozoites requires multiple steps that are regulated signaling pathways. Exposure of P. falciparum to the physiological signal low K + , as found in plasma, leads a rise cytosolic Ca 2+ which mediates microneme secretion, motility, and invasion. We have used global phosphoproteomic analysis identify pathways activated during Using quantitative phosphoproteomics we 394 protein phosphorylation site changes subjected different ionic...