Solvents are crucial platforms in organic synthesis. Thereby, the choice of a solvent is critical order to develop sustainable eco-friendly synthetic methodologies. Hence, present consensus employ environmentally friendly solvents which have broad applications fine chemical syntheses, especially from context large-scale industrial preparations. In this review, we provide several examples for utilization 2-MeTHF, CPME, and 4-MeTHP reactions pertaining organometallic-, organo-, biocatalysis...

The interaction between the plasma protein bovine serum albumin (BSA) and drug ibuprofen (IBU) has been investigated at three different pH values (7.4, 6.5, 8.0) in presence of oligosaccharides surfactants. analysis BSA with surfactants also studied absence ibuprofen. results obtained give convenient efficient access to understand mechanism binding BSA, major forces involved are found be hydrophobic forces, hydrogen bonding ionic interactions. In addition that, formation inclusion complexes...

Carbon quantum dots (CQD) are a novel class of nanomaterials that has significant importance for applications in bioimaging, drug loading and delivery. Their easy preparation, tunable optoelectronic property, low toxicity, excellent biocompatibility, superior photostability, exceptional water solubility contribute to their tremendous potentials various applications. In this study, we synthesized carbon using greener cost-efficient top-down reflux methods, characterized the CQDs by...

Abstract Total internal reflection fluorescence (TIRF) microscopy enables observation of complex bio-assemblies and macromolecular dynamics in high spatial-temporal resolution at single-molecule level real-time. With TIRF illumination, fluorophores near a sample substrate are excited by an evanescent field, thereby circumventing the axial diffraction limit light. Prism-based (p-TIRF) microscopes comparatively easy to use. They may be readily adjusted meet requirements broad range...

ABSTRACT Biodegradable starch (Str) polymer was derived from potato, a plant‐based natural carbohydrate polymers source, by one‐pot synthesis. Hydroxyapatite (HA) produced goat bone step sintering. The inexpensive starch/HA thin film composites were fabricated customized spin coating. This study revealed that the hydrogen bond energy and distance have significant effect on glass transition temperature of polymer. 40 wt % HA contained (StrHA40) composite showed excellent tensile strength...

Post-synthetic modification of organic linkers embedded in a metal–organic framework (MOF) is favourable strategy to improve the storage hydrogen through physisorption at ambient conditions. Density functional and domain-based local pair natural orbital coupled cluster calculations are conducted evaluate feasibility adsorption on open metal sites Napthalene Dicarboxylate-based linker. Both alkaline ions like Ca2+ Mg2+ transition Zn2+ Cd2+ chosen for this study. DFT DLPNO-CCSD(T) energies...

Understanding the binding details of a small-molecule drug to protein in its partially unfolded state is important for delivery as it provides insight into overall drug-binding ability protein, even when majority pockets are impaired. The interaction proteins with drugs remains poorly understood due lack structural information on their states. Here, we studied between serum albumin (bovine (BSA) model system), an abundant blood that effective carrier numerous known drugs, and nonsteroidal...

Abstract Active enzymes during catalyzing chemical reactions, have been found to generate significant mechanical fluctuations, which can influence the dynamics of their surroundings. These phenomena open new avenues for controlling mass transport in complex and dynamically inhomogeneous environments through localized reactions. To explore this potential, we studied uptake transferrin molecules retinal pigment epithelium (RPE) cells via clathrin-mediated endocytosis. In presence enzyme...

Understanding the interaction between drug:carrier complex and protein is essential for development of a new drug-delivery system. However, majority reports are based on an understanding interactions drug protein. Here, we present our findings anti-inflammatory diflunisal with carrier cyclodextrin (CD) lysozyme, utilizing steady-state time-resolved fluorescence spectroscopy. Our reveal different pattern molecular inclusion β-CD (β-CD) or hydroxypropyl-β-CD (HP-β-CD) (as host) guest) in...

Clinical trials on the therapeutic effect of curcumin have proven to be highly effective against many diseases including cancer and Alzheimer's. However, molecular mechanism interaction with protein live cell membrane is poorly understood. Here, we report bovine serum albumin (BSA) E. coli in presence organized assemblies sodium dodecyl sulfate (SDS) cetrimonium bromide (CTAB) by fluorescence spectroscopy, laser-scanning confocal microscopy, computation. Enhanced binding constant,...

DNA Holliday junctions (HJs) are crucial intermediates in genetic recombination and genome repair processes, characterized by a dynamic nature transitioning among multiple conformations on the timescale ranging from sub-milliseconds to seconds.

To improve bioavailability, enhance the solubility and stability of hydrophobic drug curcumin, nanoparticles such as carbon quantum dots (CQDs) are unique choices. In this study, we present a simple, cost‐effective, eco‐friendly method for synthesizing nitrogen‐doped (N‐CQDs) their application in efficient delivery drugs curcumin into live cancer cells. The N‐CQDs produced study exhibit excellent water solubility, remarkable stability, high biocompatibility. synthesize N‐CQD, use source...