A5036401024- Effects and risks of endocrine disrupting chemicals
- Selenium in Biological Systems
- Heavy Metal Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Pesticide Exposure and Toxicity
- Mycotoxins in Agriculture and Food
- Toxic Organic Pollutants Impact
- Neonatal Health and Biochemistry
- Thyroid Disorders and Treatments
- Glutathione Transferases and Polymorphisms
- Computational Drug Discovery Methods
- Wheat and Barley Genetics and Pathology
- Animal testing and alternatives
- Anesthesia and Neurotoxicity Research
- Microplastics and Plastic Pollution
- Ovarian function and disorders
- Drug-Induced Hepatotoxicity and Protection
- Iron Metabolism and Disorders
- Chemical Analysis and Environmental Impact
- Insect and Pesticide Research
- Antioxidant Activity and Oxidative Stress
- Trace Elements in Health
- Bone health and osteoporosis research
- Dye analysis and toxicity
- Birth, Development, and Health
Okan University
2025
Lokman Hekim Üniversitesi
2018-2024
Hacettepe University
2012-2021
Hacettepe University Hospital
2017
Chung Yuan Christian University
2015
Ankara Onkoloji Eğitim ve Araştırma Hastanesi
2010
Several untoward health effects of phthalates, which are a group industrial chemicals with many commercial uses including personal-care products and plastic materials, have been defined. The most commonly used, di-(2-ethylhexyl)-phthalate (DEHP), is known to antiandrogenic or estrogenic both. Mono-(2-ethylhexyl)-phthalate (MEHP) the main metabolite DEHP. In this study, we aimed determine plasma DEHP MEHP levels in pubertal gynecomastia cases.The study comprised 40 newly diagnosed cases who...
Endocrine disruptors have been proposed in the etiology of polycystic ovary syndrome (PCOS) as they potency to interfere with hormone-sensitivity systems. The aim this study was evaluate levels bisphenol A (BPA) and phtalates adolescents PCOS. Sixty-two girls PCOS 33 controls, age 12–18 years were enrolled study. diagnosis made using modified Rotterdam criteria. Urinary BPA measured high-performance liquid chromatography. Di-(2-ethylhexyl)-phthalate (DEHP), most commonly used phthalate...
Summary This study was performed to determine the hepatotoxicity of di(2‐ethylhexyl)phthalate ( DEHP ) in relation selenium status. In 3‐week‐old Sprague‐Dawley rats, deficiency induced by a ≤0.05 mg/kg. A supplementation group given 1 mg selenium/kg diet for 5 weeks. Di(2‐ethylhexyl)phthalate‐treated groups received 1000 mg/kg dose gavage during last 10 days experiment. Histopathology, peroxisome proliferation, catalase CAT immunoreactivity and activity apoptosis were assessed. Activities...
Bisphenol A (BPA) is an industrial chemical, particularly used to harden plastics. BPA thought have negative health effects on both laboratory animals and humans. Consider ing the decline in age of onset puberty noted recent years, among girls, importance as estrogenic endocrine disruptor has increased. In this study, we aimed determine urinary levels girls with idiopathic central precocious (ICPP).Non-obese newly diagnosed ICPP (n=28, 4-8 years) constituted study group. The control group...
Exposure to environmental chemicals can affect genetic and epigenetic molecular pathways may cause altered growth development. Among those exposures, endocrine-disrupting (EDCs) are of particular concern as humans abundantly exposed these by various means in every period life. Several well-known chemicals, including phthalates bisphenol A (BPA), classified EDCs. These EDCs suggested play roles early onset puberty girls. The aim this study is determine plasma phthalate...
Bisphenol A (BPA) is a well-known endocrine disruptor and it widely used mainly in the plastics industry. Due to recent reports on its possible impact health (particularly male reproductive system), bisphenol F (BPF) S (BPS) are now being as alternatives. In this study, RWPE-1 cells were model compare cytotoxicity, oxidative stress-causing potential genotoxicity of these chemicals. addition, effects derivatives assessed DNA repair proteins. incubated with BPA, BPF, BPS at concentrations...
Di-2-(ethylhexyl)phthalate (DEHP) is a phthalate derivative used extensively in wide range of materials, such as medical devices, toys, cosmetics, and personal care products. Many mechanisms, including epigenetics, may be involved the effects phthalates on brain development. In this study, Sprague-Dawley male rats were obtained 21-23 days after their birth (post-weaning) exposed to DEHP during prepubertal period with low-dose (DEHP-L, 30 mg/kg/day) high-dose (DEHP-H, 60 mg/kg/day, 37 days)...
This study compared surface roughness, monomer release, and, cytotoxicity of temporary fixed prosthetic materials manufactured using the conventional, CAD/CAM milling and 3D printing methods. Disc-shaped samples (2 mm height, 5 diameter) were prepared from four [polyethyl methacrylate/polymethyl methacrylate (Dentalon Plus-DP), bis-acrylic composite resin (Protemp 4-PT), polymethyl disc (On Dent), methacrylate-based (QuraCROWN Temp)]. Surface roughness was measured with a profilometer;...
Di(ethylhexyl)phthalate (DEHP), the most widely used plasticizer, was investigated to determine whether an oxidative stress process one of underlying mechanisms for its testicular toxicity potential. To evaluate effects selenium (Se), status on DEHP further objective this study, as Se is known play a critical role in testis and modulation intracellular redox equilibrium. deficiency produced 3‐weeks‐old Sprague–Dawley rats feeding them ≤0.05 mg /kg diet 5 weeks, Se‐supplementation group 1...
Phthalates are abundantly produced plasticizers, and di(ethylhexyl) phthalate (DEHP) is the most widely used derivative in various consumer products medical devices. Animal studies show that DEHP other phthalates cause reproductive developmental toxicity. Although evidences limited, it seems reasonable may have a potential for similar adverse effects humans. Such concerns increasing, particularly developing system of male infants children. By taking into account essentiality selenium (Se)...
This study was designed to examine the oxidative stress potential of di(2-ethylhexyl)phthalate (DEHP) on rat kidney and evaluate possible protective effect selenium (Se) status. Se deficiency (SeD) produced in 3-week old Sprague-Dawley rats by feeding them ≤ 0.05 mg/kg diet for 5 weeks; supplementation group (SeS) 1 mg Se/kg diet. DEHP treated groups received 1000 dose gavage during last 10 days period. Activities antioxidant selenoenzymes [glutathione peroxidase (GPx1), glutathione 4...
In this study, we aimed to investigate whether bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP) exposure have any association with Hashimoto's thyroiditis (HT) its biomarkers determine oxidative stress trace element levels showed alterations in children HT. We found that superoxide dismutase glutathione peroxidase activities are lower HT group from control (24% 46%, respectively, p < 0.05). Zinc were significantly vs. control. addition, the of mono-(2-ethylhexyl) (MEHP) which is...