A5065208106- Autoimmune Neurological Disorders and Treatments
- RNA regulation and disease
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Peptidase Inhibition and Analysis
- Synthesis and Reactivity of Heterocycles
- Multiple Sclerosis Research Studies
- Cancer-related molecular mechanisms research
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Circular RNAs in diseases
- Synthesis and biological activity
- Synthesis of Organic Compounds
- Advanced Neuroimaging Techniques and Applications
Ruijin Hospital
2022-2024
Shanghai Jiao Tong University
2022-2024
Nantong University
2022
Southern Medical University
2020
Long noncoding RNAs (lncRNAs) can act as oncogene and tumor suppressor genes in many types of cancers including breast cancer (BC). Our previous study has indicated microRNA (miR)-125a-5p was downregulated function a BC. However, its upstream regulation mechanism is still unclear. In this study, we used bioinformatics algorithms, RNA pulldown assay, dual-luciferase reports assay to predict confirm lncRNA CERS6-AS1 interacted with miR-125a-5p. Then found upregulated BC tissues. Experimental...
Objective Anti-dipeptidyl-peptidase-like protein-6 (DPPX) encephalitis is a rare autoimmune encephalitis, and clinical experimental information regarding this disease limited. We conducted study to comprehensively describe the characteristics, ancillary test results, neuroimaging treatment response in group of Chinese patients with anti-DPPX for better understanding disease. Methods recruited 14 who tested positive antibodies serum and/or cerebrospinal fluid from 11 medical centers between...
Abstract A series of new functionalized pyridinyl‐spirooxindoles have been synthesized through three‐component cyclization reactions. The selected compounds were screened for their in vitro antiproliferative activity against human lung cancer cell line A549. Among the candidate structures, compound 1o demonstrated maximum inhibitory A549 cells with IC 50 values 28.38 μM. EdU (5‐Ethynyl‐2′‐ deoxyuridine, EdU) assay and colony formation test showed that proliferation was inhibited. In...
Anti-glutamate kainate receptor subunit 2 (Gluk2) autoimmune encephalitis (AE) is a novel and very rare neuroimmune disease that was first reported in 2021.1 Eight patients with this form of AE have been globally.1 Herein, we report patient anti-Gluk2 antibodies presenting as cerebellar dysfunctions limbic encephalitis. Our case can contribute to better understanding newly discovered AE. In September 2022, previously healthy 27-year-old woman admitted for 1.5-year history intermittent...
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that rare in China. At present, there are no widespread quantitative imaging markers associated with severity MS. Despite several previous studies reporting cerebral blood flow (CBF) changes MS, consensus has been reached. In this study, we enrolled 30 Eastern MS patients to investigate CBF different brain regions using arterial spin labeling technique and their relationship severity. The average were...