A5016028969- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Cystic Fibrosis Research Advances
- Pancreatitis Pathology and Treatment
- Angiogenesis and VEGF in Cancer
- Cardiovascular Function and Risk Factors
- Pancreatic and Hepatic Oncology Research
- Inflammatory Biomarkers in Disease Prognosis
- Diabetes Management and Education
- Lymphatic System and Diseases
- Cardiovascular Disease and Adiposity
- Neonatal Respiratory Health Research
- Sleep and related disorders
- Health and Lifestyle Studies
- Neuropeptides and Animal Physiology
- Child Nutrition and Feeding Issues
- Diet and metabolism studies
- Gut microbiota and health
- Lipid metabolism and disorders
- Renal Transplantation Outcomes and Treatments
- Clostridium difficile and Clostridium perfringens research
- Cannabis and Cannabinoid Research
- Organ Transplantation Techniques and Outcomes
University of Pennsylvania
2021-2024
Newcastle University
2019-2024
Hospital of the University of Pennsylvania
2022
Newcastle upon Tyne Hospitals NHS Foundation Trust
2019-2021
Freeman Hospital
2019-2021
Newcastle upon Tyne Hospital
2020
Portsmouth Hospitals NHS Trust
2017
University of Ulster
2010
Automated insulin delivery (AID) may benefit individuals with long-standing type 1 diabetes where frequent exposure to hypoglycemia impairs counterregulatory responses. This study assessed the effect of 18 months AID on avoidance and glucose responses insulin-induced in complicated by impaired awareness hypoglycemia.
OBJECTIVE The HypoCOMPaSS study was designed to test the hypothesis that successful avoidance of biochemical hypoglycemia without compromising overall glycemic control would restore sufficient awareness prevent recurrent severe in majority participants with established type 1 diabetes. Before starting study, we planned investigate associations between baseline characteristics and over 2 years’ follow-up. RESEARCH DESIGN AND METHODS A total 96 adults diabetes impaired participated a 24-week ×...
Impaired insulin and incretin secretion underlie abnormal glucose tolerance (AGT) in pancreatic insufficient cystic fibrosis (PI-CF). Whether the hormones glucagon-like peptide-1 (GLP-1) glucose-dependent insulinotropic polypeptide (GIP) can enhance islet function (CF) is not known. We studied 32 adults with PI-CF AGT randomized to receive either GLP-1 (n = 16) or GIP during glucose-potentiated arginine (GPA) testing of on two occasions, placebo infused, a randomized, double-blind,...
The UK islet allotransplant program is nationally funded to deliver one or two transplants over 12 months individuals with type 1 diabetes and recurrent severe hypoglycemia. Analyses were undertaken 10 years after inception evaluate associations between transplanted mass; single versus transplants; time graft survival (stimulated C-peptide >50 pmol/L) function. In total, 84 transplant recipients studied. Uninterrupted was attained in 23 (68%) 47 (94%) (p = .002) (separated by [median (IQR)]...
Repeated hypoglycemia exposure leads to impaired awareness of (IAH) and the development defective counterregulatory responses. To date, only pancreas or islet transplantation has demonstrated normalization endogenous glucose production (EGP) response defend against insulin-induced in long-standing type 1 diabetes (T1D). This study aims validate clinical metrics IAH (Clarke score), severity (HYPO glycemic lability (lability index), continuous monitoring (CGM) as predictors absent autonomic...
OBJECTIVE To investigate the impact of residual β-cell function on continuous glucose monitoring (CGM) outcomes following acute exercise in people with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS Thirty participants T1D for ≥3 years were recruited. First, wore a blinded CGM unit 7 days free-living data capture. Second, 3-h mixed-meal test assessed stimulated C-peptide and glucagon. Peak was used to allocate into undetectable (Cpepund <3 pmol/L), low (Cpeplow 3–200 or high...
Abstract Context Elexacaftor/tezacaftor/ivacaftor (ETI; Trikafta) enhances aberrant cystic fibrosis transmembrane conductance regulator function and may improve the insulin secretory defects associated with a deterioration in clinical outcomes pancreatic insufficient (PI-CF). Objective This longitudinal case-control study assessed changes β-cell capacity measures over 2 visits individuals PI-CF who were initiated on ETI after baseline visit (2012-2018) (1) restudied between 2019 2021 (ETI...
ObjectiveTo evaluate the discriminant and convergent validities of Hypoglycemia Awareness Questionnaire Impaired (HypoA-Q IA) subscale establish a diagnostic threshold for classification impaired awareness hypoglycemia (IAH) in adults with type 1 diabetes (T1D).MethodsTwenty-one T1D (male, 48%; median age, 36 years; duration, 21 years) completed HypoA-Q IA subscale, Clarke, severity (HYPO) scores, continuous glucose monitoring, hyperinsulinemic hypoglycemic clamp testing. Those IAH defined...
This study assessed changes in actigraphy-estimated sleep and glycemic outcomes after initiating automated insulin delivery (AID).
Abstract Exercise mobilizes angiogenic cells, which stimulate vascular repair. However, limited research suggests exercise-induced increase of endothelial progenitor cell (EPCs) is completely lacking in type 1 diabetes (T1D). Clarification, along with investigating how T1D influences increases other cells (hematopoietic cells; HPCs) and surface expression chemokine receptor 4 (CXCR4) 7 (CXCR7), needed. Thirty patients 30 matched non-diabetes controls completed 45 min incline walking....
The psychological burden experienced by people with diabetes prior to islet transplantation is recognized but has not been studied comprehensively, especially in relation glycemia. Therefore, we conducted a rigorous pre-operative psychosocial profile of UK transplant recipients, and compared groups higher/lower HbA1 c test the null hypothesis that pre-transplant hypoglycemia awareness would be related baseline this high-risk cohort. Pre-transplant, recipients (n = 44) completed validated...
Islet transplantation is an effective therapy for life-threatening hypoglycemia, but graft function gradually declines over time in many recipients. We characterized islet-specific T cells recipients within islet transplant program favoring alemtuzumab (ATZ) lymphodepleting induction and examined associations with function. Fifty-eight were studied: 23 pretransplant 40 posttransplant (including 5 phenotyping). The proportion cell responses was not significantly different (pre-Tx: 59%; 1-6 m...
The HypoCOMPaSS multi-centre trial achieved improvement in hypoglycaemia awareness and 20-fold reduction severe (SH) a cohort with long-standing type 1 diabetes (T1D). All participants received 'my hypo compass' (MHC) brief structured psycho-educational intervention addition to optimisation of insulin delivery/glucose monitoring. In this 24-week, prospective, single-centre feasibility RCT, we piloted MHC as sole comparison standard clinical care alone (CON).
Transplanted islet functional β-cell mass is measured by the secretory capacity derived from acute insulin response to glucose-potentiated arginine (AIRpot), however, data are limited beyond one-year post-transplant for individuals with type 1 diabetes. We evaluated changes in a single-center longitudinal analysis and examined relationships measures of cell hormone metabolism clinical graft function (mixed-meal tolerance test [MMTT] C-peptide, BETA-2 score, continuous glucose monitoring...
<p dir="ltr">Transplanted islet functional β-cell mass is measured by the secretory capacity derived from acute insulin response to glucose-potentiated arginine (AIRpot), however, data are limited beyond one-year post-transplant for individuals with type 1 diabetes. We evaluated changes in a single-center longitudinal analysis and examined relationships measures of cell hormone metabolism clinical graft function (mixed-meal tolerance test [MMTT] C-peptide, BETA-2 score, continuous...
<p dir="ltr">Transplanted islet functional β-cell mass is measured by the secretory capacity derived from acute insulin response to glucose-potentiated arginine (AIRpot), however, data are limited beyond one-year post-transplant for individuals with type 1 diabetes. We evaluated changes in a single-center longitudinal analysis and examined relationships measures of cell hormone metabolism clinical graft function (mixed-meal tolerance test [MMTT] C-peptide, BETA-2 score, continuous...
Aims: Endothelial and Hematopoietic Progenitor Cells (EPCs HPCs) promote vascular health through secreting proangiogenic factors replacing damaged cells. Exercise has been shown to be a mobiliser of these rare cells in healthy individuals, however, the response chronic diseases such as type 1 diabetes (T1D) is unclear. We compared EPC HPC counts at rest after acute exercise people with without T1D. Methods: Thirty T1D participants (38±12 years, HbA1c 58.5±9.3 mmol/mol-1, duration 20±13...