A5102932933- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Vitamin C and Antioxidants Research
- Metabolism and Genetic Disorders
- SARS-CoV-2 and COVID-19 Research
- Heat shock proteins research
- Redox biology and oxidative stress
- Biochemical effects in animals
- COVID-19 Clinical Research Studies
- Regulation of Appetite and Obesity
Tianjin Medical University
2020-2025
Institute of Endocrinology
2020
Reactive oxygen species exacerbate nonalcoholic steatohepatitis (NASH) by oxidizing macromolecules; yet how they promote NASH remains poorly understood. Here, we show that peroxidase activity of global hepatic peroxiredoxin (PRDX) is significantly decreased in NASH, and palmitic acid (PA) binds to PRDX1 inhibits its activity. Using three genetic models, demonstrate protects against male mice. Mechanistically, suppresses STAT signaling mitochondrial function scavenging hydrogen peroxide,...
Peroxiredoxin 1 (PRDX1) is a peroxidase and guards against oxidative stress by scavenging intracellular peroxides, whereas it also has been shown to stimulate inflammatory response functioning as chaperone protein. The potential in vivo link between PRDX1's activity its pro-inflammatory remains elusive. We generated peroxidase-dead PRDX1 variant mice mutating peroxidatic cysteine at 52 (Cys52) serine, here referred PRDX1Cys52Ser. Trx-TrxR-NADPH coupled assay was applied evaluate the of...
The paraventricular hypothalamus (PVH) is crucial for food intake control, yet the presynaptic mechanisms underlying PVH neurons remain unclear. Here, we show that RUVBL2 in significantly reduced during energy deficit, and knockout (KO) of results hyperphagic obesity mice. RUVBL2-expressing (PVH
Arginase, a manganese (Mn)-dependent enzyme, is indispensable for urea generation and ammonia disposal in the liver. The potential role of fructose Mn metabolism undefined. Here we demonstrate that overconsumption impairs hepatic homeostasis male mice. Fructose overexposure reduces liver content as well its activity arginase Mn-SOD, clearance blood under dysfunction. Mechanistically, activates exporter Slc30a10 gene transcription ChREBP-dependent manner. Hepatic overexpression can mimic...
Excessive reactive oxygen species (ROS) is highly involved in inflammation and the pathogenesis of infectious diseases. As a potent scavenger ROS, peroxiredoxin 1 (PRDX1) promising therapeutic target for treating ROS-related diseases, however, its agonist has not been identified yet. Here we report identification cholesterol-lowering drug Fluvastatin as an effective selective PRDX1. revealed by high-resolution complex crystal structure, binds to pocket adjacent active site Activation PRDX1...